Updated on 2025/08/15

写真b

 
HATTORI Atsuhiko
 
*Items subject to periodic update by Rikkyo University (The rest are reprinted from information registered on researchmap.)
Affiliation*
College of Sport and Wellness Department of Sport and Wellness
Graduate School of Sport and Wellness Master's Program in Sport and Wellness
Title*
Specially Appointed Professor
Degree
Ph. D （ Waseda University ）
Research Interests

  • Chronobiology

  • Anti-aging Medicine

  • 比較内分泌学

  • 分子内分泌学

    • Campus Career*
    • 4 2023 - Present 
      College of Sport and Wellness   Department of Sport and Wellness   Specially Appointed Professor
    • 4 2025 - Present 
      Graduate School of Sport and Wellness   Master's Program in Sport and Wellness   Specially Appointed Professor
     

    Research Areas

    • Life Science / Morphology, anatomy

    Research History

    • 2023 - Present 
      東京医科歯科大学   名誉教授

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    • 2022 - 2023 
      東京医科歯科大学   副理事（目標・評価担当）

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    • 2000 - 2023 
      東京医科歯科大学   教授

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    • 2018 - 2022 
      東京医科歯科大学   教養部長／筆頭副理事（教養部）

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    • 1996 - 2000 
      Tokyo Medical and Dental University,

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    • 1987 - 1996 
      St. Marianna University School of Medicine,

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    • 1991 - 1992 
      University of Texas,

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    • 1986 - 1987 
      日本学術振興会 特別研究員

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    Education

    • 1981 - 1986 
      Waseda University

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      Country： Japan

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    Committee Memberships

    •  
      日本時間生物学会   評議員

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      Committee type：Academic society

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    •  
      日本抗加齢医学会   評議員

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      Committee type：Academic society

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    •  
      抗加齢内分泌研究会   代表世話人

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      Committee type：Academic society

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    Papers

    • Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity Peer-reviewed

      Suzuki N., Kuroda K., Ikegame M., Takino H., Tsunoda K., Izumi R., Tabuchi Y., Furusawa Y., Yachiguchi K., Endo M., Matsubara H., Yano S., Shimazu T., Honda M., Maruyama Y., Watanabe K., Takahashi A., Hirayama J., Hattori A.

      Life Sci. Space Res.46 - 136   5 4 2025

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      Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.lssr.2025.04.004

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    • Three-dimensional visualization of calcification during scale regeneration in goldfish Peer-reviewed

      Hisayuki Funahashi, Yusuke Maruyama, Nobuo Suzuki, Takashi Takaki, Kazuho Honda, Atsuhiko Hattori

      Medical Molecular Morphology   6 3 2025

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      Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

      DOI： 10.1007/s00795-025-00427-1

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      Other Link： https://link.springer.com/article/10.1007/s00795-025-00427-1/fulltext.html

    • Hydroxylated-Benz[a]anthracenes Induce Two Apoptosis-Related Gene Expressions in the Liver of the Nibbler Fish Girella punctata Peer-reviewed

      Muhammad Ahya Rafiuddin, Hajime Matsubara, Kaito Hatano, Masato Honda, Kenji Toyota, Kouhei Kuroda, Keito Tsunoda, Yukihiro Furusawa, Yoshiaki Tabuchi, Tetsushi Hirano, Akihiro Sakatoku, Chun-Sang Hong, Ajai K. Srivastav, Thumronk Amornsakun, Nobuaki Shimizu, Mohamed I. Zanaty, Tatsuo Harumi, Kohei Yamauchi, Tamás Müller, Ning Tang, Atsuhiko Hattori, Kazuichi Hayakawa, Nobuo Suzuki

      Toxics12 ( 12 ) 915 - 915   18 12 2024

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      Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

      Polycyclic aromatic hydrocarbons (PAHs) are known to have toxic effects on fish. In this study, we examined the effects of benz[a]anthracene (BaA), a type of PAH, on fish liver metabolism. Nibbler fish (Girella punctata) were intraperitoneally injected with BaA (10 ng/g body weight) four times over a 10-day period. BaA significantly decreased known bone metabolism-related plasma factors such as calcium and inorganic phosphorus. Moreover, significant reductions were observed in the plasma levels of known liver metabolism-related factors, including ferrous ions, total bile acids, total bilirubin, free bilirubin, aspartate aminotransferase, and alkaline phosphatase. Interestingly, mono-hydroxylated metabolites of BaA, such as 3 hydroxylbenz[a]anthracene (3-OHBaA), were detected in the bile of BaA-injected nibbler fish. This hydroxylated form of BaA was found in its free form, rather than conjugated with glucuronic acid or sulfuric acid. Due to the lack of whole-genome sequence data for the nibbler fish, two nibbler fish-specific apoptosis-related factors (TNF receptor superfamily member 1A: tnfrsf1a and TNF superfamily member 10: tnfsf10) were isolated by De novo RNA sequencing. In a liver tissue culture, 3-OHBaA (10−6 M) significantly upregulated the expression of tnfrsf1a and tnfsf10 in the liver. These results provide the first evidence that 3-OHBaA metabolites exhibit toxic effects on the liver in teleost.

      DOI： 10.3390/toxics12120915

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    • Bone regeneration–enhancing effects of extremely low-frequency electromag- netic fields: Analysis using fish scales as a bone model Peer-reviewed

      Nobuo SUZUKI, Makiko KAKIKAWA, Yuta ODA, Jingjing KOBAYASHI-SUN, Sotoshi YAMADA, Kouhei KURODA, Isao KOBAYASHI, Masato HONDA, Hajime MATSUBARA, Yoshiaki TABUCHI, Nobuaki SHIMIZU, Kazuki WATANABE, Jun HIRAYAMA, Atsuhiko HATTORI

      Biomedical Research45 ( 5 ) 187 - 195   1 10 2024

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      Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Biomedical Research Press  

      DOI： 10.2220/biomedres.45.187

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    • Highly purified hypochlorous acid water facilitates glucose metabolism and memory formation in type 2 diabetic mice associated with altered-gut microbiota Peer-reviewed

      Kazuki Watanabe, Yusuke Maruyama, Risako Mikami, Keiji Komatsu, Kenji Kikuchi, Kunimoto Hotta, Toshikazu Yoshikawa, Kouetsu Ogasawara, Atsuhiko Hattori, Shinichi Arakawa

      Scientific Reports14 ( 1 )   12 7 2024

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      Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

      Abstract

      Hypochlorous acid (HOCl) is an endogenous oxidant and chlorinating agent in mammals that is effective against a broad range of microorganisms. However, the effects of exogenous HOCl on biological processes have not been reported. In this study, the effects of highly purified slightly acidic hypochlorous acid water (HP-HAW) were investigated. After the safety of oral administration of HP-HAW was confirmed, the effects of HP-HAW on glucose homeostasis were assessed in mice. HP-HAW treatment significantly improved blood glucose levels in hyperglycemic condition. Based on the 16S rRNA sequencing, HP-HAW treatment significantly increased the diversity and changed the composition of gut microbiota by decreasing the abundance of genus Romboutsia in mice fed normal chow. In obese mice, HP-HAW administration tended to improve glucose tolerance. HP-HAW also attenuated memory impairments and changes N-methyl-d-aspartate (NMDA) receptor mRNA expression in obese mice. HP-HAW treatment suppressed Il-6 mRNA expression in the hippocampus in type 2 diabetic mice. Overall, these results support HP-HAW as a potential therapeutic agent to improve or prevent glucose tolerance and memory decline via gut microbiota alteration.

      DOI： 10.1038/s41598-024-67129-z

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      Other Link： https://www.nature.com/articles/s41598-024-67129-z

    • Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine, a melatonin metabolite, in the hippocampus: a potential prophylactic agent for dementia Peer-reviewed

      Kazuki Watanabe, Atsuhiko Hattori

      Neural Regeneration Research20 ( 6 ) 1705 - 1706   10 7 2024

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      Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Medknow  

      DOI： 10.4103/nrr.nrr-d-24-00379

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    • Genetic analysis of impaired healing responses after periodontal therapy in type 2 diabetes: Clinical and in vivo studies Peer-reviewed

      Keita Nakagawa, Kazuki Watanabe, Koji Mizutani, Kohei Takeda, Shu Takemura, Eri Sakaniwa, Risako Mikami, Daisuke Kido, Natsumi Saito, Hiromi Kominato, Atsuhiko Hattori, Takanori Iwata

      Journal of Periodontal Research59 ( 4 ) 712 - 727   19 3 2024

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      Publishing type：Research paper (scientific journal)   Publisher：Wiley  

      Abstract

      Objective

      This study aims to investigate the mechanisms underlying the impaired healing response by diabetes after periodontal therapy.

      Background

      Outcomes of periodontal therapy in patients with diabetes are impaired compared with those in patients without diabetes. However, the mechanisms underlying impaired healing response to periodontal therapy have not been sufficiently investigated.

      Materials and Methods

      Zucker diabetic fatty (ZDF) and lean (ZL) rats underwent experimental periodontitis by ligating the mandibular molars for one week. The gingiva at the ligated sites was harvested one day after ligature removal, and gene expression was comprehensively analyzed using RNA‐Seq. In patients with and without type 2 diabetes (T2D), the corresponding gene expression was quantified in the gingiva of the shallow sulcus and residual periodontal pocket after non‐surgical periodontal therapy.

      Results

      Ligation‐induced bone resorption and its recovery after ligature removal were significantly impaired in the ZDF group than in the ZL group. The RNA‐Seq analysis revealed 252 differentially expressed genes. Pathway analysis demonstrated the enrichment of downregulated genes involved in the peroxisome proliferator‐activated receptor (PPAR) signaling pathway. PPARα and PPARγ were decreased in mRNA level and immunohistochemistry in the ZDF group than in the ZL group. In clinical, probing depth reduction was significantly less in the T2D group than control. Significantly downregulated expression of PPARα and PPARγ were detected in the residual periodontal pocket of the T2D group compared with those of the control group, but not in the shallow sulcus between the groups.

      Conclusions

      Downregulated PPAR subtypes expression may involve the impaired healing of periodontal tissues by diabetes.

      DOI： 10.1111/jre.13249

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    • Dietary melatonin and liver cancer incidence in Japan: From the Takayama study Peer-reviewed

      Keiko Wada, Atsuhiko Hattori, Yusuke Maruyama, Tomoka Mori, Masaaki Sugino, Yuma Nakashima, Michiyo Yamakawa, Masayuki Yamamoto, Akihiro Hori, Mitsuru Seishima, Shinobu Tanabashi, Shogen Matsushita, Chisato Nagata

      Cancer Science115 ( 5 ) 1688 - 1694   14 2 2024

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      Publishing type：Research paper (scientific journal)   Publisher：Wiley  

      Abstract

      There is some biological plausibility that exogenous melatonin plays a role in preventing liver carcinogenesis. There has been little research on the association between melatonin intake in a normal diet and health outcomes. We evaluated the association between dietary melatonin intake and the incidence of liver cancer in a population‐based prospective study in Japan. This study included 30,824 residents of Takayama city who were 35 years of age or older in 1992 and had participated in the Takayama study, Japan. Dietary intake was assessed using a validated food frequency questionnaire at the baseline. Melatonin content in foods was measured by liquid chromatography–tandem mass spectrometry. Cancer incidence was confirmed through regional population‐based cancer registries in Gifu. Liver cancer was defined as code C22 according to the International Classification of Diseases and Related Health Problems, 10th Revision. Hazard ratios for liver cancer were estimated for the tertile groups of melatonin intake using a Cox proportional hazards model. During the mean follow‐up period of 13.6 years, 189 individuals developed liver cancer. Compared with subjects in the lowest tertile of melatonin intake, those in the middle and highest tertiles had decreased risks of liver cancer, with a significant linear trend after multivariate adjustments (hazard ratios: 0.64 and 0.65, respectively, trend p = 0.023). There was no significant interaction by sex (interaction p = 0.54). This initial finding, which needs to be confirmed by further studies, suggests that consuming melatonin‐containing foods might play a role in the prevention of liver cancer.

      DOI： 10.1111/cas.16103

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    • Receptor-Mediated and Receptor-Independent Actions of Melatonin in Vertebrates Peer-reviewed

      Atsuhiko Hattori, Nobuo Suzuki

      Zoological Science41 ( 1 )   12 1 2024

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      Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Zoological Society of Japan  

      DOI： 10.2108/zs230057

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    • N1-Acetyl-5-methoxykynuramine, which decreases in the hippocampus with aging, improves long‐term memory via CaMKII/CREB phosphorylation

      Kazuki Watanabe, Yusuke Maruyama, Hikaru Iwashita, Haruyasu Kato, Jun Hirayama, Atsuhiko Hattori

      Journal of Pineal Research76 ( 1 )   12 1 2024

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      Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

      Abstract

      Melatonin is a molecule ubiquitous in nature and involved in several physiological functions. In the brain, melatonin is converted to N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) and then to N1‐acetyl‐5‐methoxykynuramine (AMK), which has been reported to strongly enhance long‐term object memory formation. However, the synthesis of AMK in brain tissues and the underlying mechanisms regarding memory formation remain largely unknown. In the present study, young and old individuals from a melatonin‐producing strain, C3H/He mice, were employed. The amount of AMK in the pineal gland and plasma was very low compared with those of melatonin at night; conversely, in the hippocampus, the amount of AMK was higher than that of melatonin. Indoleamine 2, 3‐dioxygenase (Ido) mRNA was expressed in multiple brain tissues, whereas tryptophan 2,3‐dioxygenase (Tdo) mRNA was expressed only in the hippocampus, and its lysate had melatonin to AFMK conversion activity, which was blocked by the TDO inhibitor. The expression levels of phosphorylated cAMP response element binding protein (CREB) and PSD‐95 in whole hippocampal tissue were significantly increased with AMK treatment. Before increasing in the whole tissue, CREB phosphorylation was significantly enhanced in the nuclear fraction. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, we found that downregulated genes in hippocampus of old C3H/He mice were more enriched for long‐term potentiation (LTP) pathway. Gene set enrichment analysis showed that LTP and neuroactive receptor interaction gene sets were enriched in hippocampus of old mice. In addition, Ido1 and Tdo mRNA expression was significantly decreased in the hippocampus of old mice compared with young mice, and the decrease in Tdo mRNA was more pronounced than Ido1. Furthermore, there was a higher decrease in AMK levels, which was less than 1/10 that of young mice, than in melatonin levels in the hippocampus of old mice. In conclusion, we first demonstrated the Tdo‐related melatonin to AMK metabolism in the hippocampus and suggest a novel mechanism of AMK involved in LTP and memory formation. These results support AMK as a potential therapeutic agent to prevent memory decline.

      DOI： 10.1111/jpi.12934

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    • Data on plasma cortisol levels in nibbler fish Girella punctata reared under high-density conditions in either surface seawater or deep ocean water Peer-reviewed

      Ikari T, Hirayama J, Rafiuddin MA, Furusawa Y, Tabuchi Y, Watanabe K, Hattori A, Kawashima R, Nakamura K, Srivastav AK, Toyota K, Matsubara H, Suzuki N

      Data Brief49   109361 - 109361   7 2023

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      Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

      DOI： 10.1016/j.dib.2023.109361

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    • Melatonin is more effective on bone metabolism when given at early night than during the day in ovariectomized rats. Peer-reviewed

      Yukari Miki, Azusa Seki, Hiroyuki Mishima, Yusuke Maruyama, Kazuki Watanabe, Jingjing Kobayashi-Sun, Isao Kobayashi, Kohei Kuroda, Shion Oshima, Takeru Okamoto, Hajime Matsubara, Ajai K. Srivastav, Yoshiaki Tabuchi, Jun Hirayama, Atsuhiko Hattori, Nobuo Suzuki

      Melatonin Research6   161 - 172   6 2023

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      Publishing type：Research paper (scientific journal)  

      DOI： 10.32794/mr112500147

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    • Kynurenine promotes Calcitonin secretion and reduces cortisol in the Japanese flounder Paralichthys olivaceus. Peer-reviewed International journal

      Takahiro Ikari, Yukihiro Furusawa, Yoshiaki Tabuchi, Yusuke Maruyama, Atsuhiko Hattori, Yoichiro Kitani, Kenji Toyota, Arata Nagami, Jun Hirayama, Kazuki Watanabe, Atsushi Shigematsu, Muhammad Ahya Rafiuddin, Shouzo Ogiso, Keisuke Fukushi, Kohei Kuroda, Kaito Hatano, Toshio Sekiguchi, Ryotaro Kawashima, Ajai K Srivastav, Takumi Nishiuchi, Akihiro Sakatoku, Masa-Aki Yoshida, Hajime Matsubara, Nobuo Suzuki

      Scientific reports13 ( 1 ) 8700 - 8700   29 5 2023

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      Language：English   Publishing type：Research paper (scientific journal)  

      Deep ocean water (DOW) exerts positive effects on the growth of marine organisms, suggesting the presence of unknown component(s) that facilitate their aquaculture. We observed that DOW suppressed plasma cortisol (i.e., a stress marker) concentration in Japanese flounder (Paralichthys olivaceus) reared under high-density condition. RNA-sequencing analysis of flounder brains showed that when compared to surface seawater (SSW)-reared fish, DOW-reared fish had lower expression of hypothalamic (i.e., corticotropin-releasing hormone) and pituitary (i.e., proopiomelanocortin, including adrenocorticotropic hormone) hormone-encoding genes. Moreover, DOW-mediated regulation of gene expression was linked to decreased blood cortisol concentration in DOW-reared fish. Our results indicate that DOW activated osteoblasts in fish scales and facilitated the production of Calcitonin, a hypocalcemic hormone that acts as an analgesic. We then provide evidence that the Calcitonin produced is involved in the regulatory network of genes controlling cortisol secretion. In addition, the indole component kynurenine was identified as the component responsible for osteoblast activation in DOW. Furthermore, kynurenine increased plasma Calcitonin concentrations in flounders reared under high-density condition, while it decreased plasma cortisol concentration. Taken together, we propose that kynurenine in DOW exerts a cortisol-reducing effect in flounders by facilitating Calcitonin production by osteoblasts in the scales.

      DOI： 10.1038/s41598-023-35222-4

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    • Nocturnal melatonin increases glucose uptake via insulin-independent action in the goldfish brain

      Kazuki Watanabe, Masaki Nakano, Yusuke Maruyama, Jun Hirayama, Nobuo Suzuki, Atsuhiko Hattori

      Frontiers in Endocrinology14   23 5 2023

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      Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

      Melatonin, a neurohormone nocturnally produced by the pineal gland, is known to regulate the circadian rhythm. It has been recently reported that variants of melatonin receptors are associated with an increased risk of hyperglycemia and type 2 diabetes, suggesting that melatonin may be involved in the regulation of glucose homeostasis. Insulin is a key hormone that regulates circulating glucose levels and cellular metabolism after food intake in many tissues, including the brain. Although cells actively uptake glucose even during sleep and without food, little is known regarding the physiological effects of nocturnal melatonin on glucose homeostasis. Therefore, we presume the involvement of melatonin in the diurnal rhythm of glucose metabolism, independent of insulin action after food intake. In the present study, goldfish (Carassius auratus) was used as an animal model, since this species has no insulin-dependent glucose transporter type 4 (GLUT4). We found that in fasted individuals, plasma melatonin levels were significantly higher and insulin levels were significantly lower during the night. Furthermore, glucose uptake in the brain, liver, and muscle tissues also significantly increased at night. After intraperitoneal administration of melatonin, glucose uptake by the brain and liver showed significantly greater increases than in the control group. The administration of melatonin also significantly decreased plasma glucose levels in hyperglycemic goldfish, but failed to alter insulin mRNA expression in Brockmann body and plasma insulin levels. Using an insulin-free medium, we demonstrated that melatonin treatment increased glucose uptake in a dose-dependent manner in primary cell cultures of goldfish brain and liver cells. Moreover, the addition of a melatonin receptor antagonist decreased glucose uptake in hepatocytes, but not in brain cells. Next, treatment with N1-acetyl-5-methoxykynuramine (AMK), a melatonin metabolite in the brain, directly increased glucose uptake in cultured brain cells. Taken together, these findings suggest that melatonin is a possible circadian regulator of glucose homeostasis, whereas insulin acquires its effect on glucose metabolism following food intake.

      DOI： 10.3389/fendo.2023.1173113

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    • Deep ocean water alters the cholesterol and mineral metabolism of squid Todarodes pacificus and suppresses its weight loss Peer-reviewed

      Kaito Hatano, Masa-Aki Yoshida, Jun Hirayama, Yoichiro Kitani, Atsuhiko Hattori, Shouzo Ogiso, Yukina Watabe, Toshio Sekiguchi, Yoshiaki Tabuchi, Makoto Urata, Kyoko Matsumoto, Akihiro Sakatoku, Ajai K. Srivastav, Kenji Toyota, Hajime Matsubara, Nobuo Suzuki

      Scientific Reports13 ( 1 )   10 5 2023

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      Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

      Abstract

      This study is the first to demonstrate that deep ocean water (DOW) has physiological significant effects on squid. After 36 h of rearing squids, those reared with DOW had significantly higher total and free cholesterol levels and lower alanine transaminase activity in hemolymph as compared with those reared with surface sea water (SSW). SSW rearing also resulted in 6.95% weight loss, while DOW rearing caused only 2.5% weight loss, which might be due to liver metabolism suppression. Furthermore, both monovalent (sodium, chloride, and potassium ions) and divalent (calcium, inorganic phosphorus, and magnesium ions) ions in hemolymph were elevated when reared with DOW compared to those when reared with SSW. A study of genes expressed in the brain revealed that five genes were specifically remarked in DOW rearing. Most altered genes were neuropeptides, including those from vasopressin superfamily. These neuropeptides are involved in cholesterol and/or mineral metabolisms and physiological significant effects on squid. This study is the first report the effects of DOW on cholesterol and mineral metabolism of squid and will contribute to squid aquaculture using DOW.

      DOI： 10.1038/s41598-023-34443-x

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      Other Link： https://www.nature.com/articles/s41598-023-34443-x

    • Adaptation to the shallow sea floor environment of a species of marine worms, Oligobrachia mashikoi, generally inhabiting deep-sea water. Peer-reviewed International journal

      Shouzo Ogiso, Kazuki Watanabe, Yusuke Maruyama, Hiroshi Miyake, Kaito Hatano, Jun Hirayama, Atsuhiko Hattori, Yukina Watabe, Toshio Sekiguchi, Yoichiro Kitani, Yukihiro Furusawa, Yoshiaki Tabuchi, Hajime Matsubara, Mana Nakagiri, Kenji Toyota, Yuichi Sasayama, Nobuo Suzuki

      Scientific reports13 ( 1 ) 6299 - 6299   18 4 2023

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      Language：English   Publishing type：Research paper (scientific journal)  

      Beard worms from the family Siboglinidae, are peculiar animals and are known for their symbiotic relationships with sulfur bacteria. Most Siboglinids inhabit the deep-sea floor, thus making difficult to make any observations in situ. One species, Oligobrachia mashikoi, occurs in the shallow depths (24.5 m) of the Sea of Japan. Taking advantage of its shallow-water habitat, the first ecological survey of O. mashikoi was performed over a course of 7 years, which revealed that its tentacle-expanding behavior was dependent on the temperature and illuminance of the sea water. Furthermore, there were significantly more O. mashikoi with expanding tentacles during the nighttime than during the daytime, and the prevention of light eliminated these differences in the number of expending tentacles. These results confirmed that the tentacle-expanding behavior is controlled by environmental light signals. Consistent with this, we identified a gene encoding a photoreceptor molecule, neuropsin, in O. mashikoi, and the expression thereof is dependent on the time of day. We assume that the described behavioral response of O. mashikoi to light signals represent an adaptation to a shallow-water environment within the predominantly deep-sea taxon.

      DOI： 10.1038/s41598-023-33309-6

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    • Possible involvement of Calcitonin I and II in calcium metabolism of the female reproductive physiology of goldfish (Carassius auratus). Peer-reviewed

      Kuroda K, Hatano K, Kawamura R, Fukushima A, Sasayama Y, Tabuchi Y, Furusawa Y, Ikegame M, Hattori A, Hirayama J, Fukuda T, Uekura S, Matsubara H, Kawago U, Sekiguchi T, Srivastav A.K, Suzuki N

      Int. Aquat. Res.In press ( https://intelaquares.tonekabon.iau.ir/article_698985.html )   2 2023

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.22034/iar.2023.1965945.1322

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    • Fluorene is Highly Toxic to Zoea Larvae of the Red-Clawed Crab Chiromantes haematocheir Peer-reviewed

      Kawamura Ryoya, Rafiuddin Ahya Muhammad, Toyota Kenji, Honda Masato, Amornsakun Thumronk, Tabuchi Yoshiaki, Hattori Atsuhiko, Harumi Tatsuo, Hirayama Jun, Urata Makoto, Matsumoto Kyoko, Nishimoto Sogo, Srivastav Ajai K, Suzuki Nobuo, Matsubara Hajime

      International Journal of Zoological Investigations9 ( 1 ) 1 - 7   1 2023

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    • Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure. International journal

      Jun Hirayama, Atsuhiko Hattori, Akihisa Takahashi, Yukihiro Furusawa, Yoshiaki Tabuchi, Masahiro Shibata, Aiko Nagamatsu, Sachiko Yano, Yusuke Maruyama, Hajime Matsubara, Toshio Sekiguchi, Nobuo Suzuki

      Journal of pineal research   e12834   6 10 2022

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      Language：English   Publishing type：Research paper (scientific journal)  

      Exposure to the space environment induces a number of pathophysiological outcomes in astronauts, including bone demineralization, sleep disorders, circadian clock dysregulation, cardiovascular and metabolic dysfunction, and reduced immune system function. A recent report describing experiments aboard the Space Shuttle mission, STS-132, showed that the level of melatonin, a hormone that provides the biochemical signal of darkness, was decreased during microgravity in an in vitro culture model. Additionally, abnormal lighting conditions in outer space, such as low light intensity in orbital spacecraft and the altered 24-hour light-dark cycles, may result in the dysregulation of melatonin rhythms and the misalignment of the circadian clock from sleep and work schedules in astronauts. Studies on Earth have demonstrated that melatonin regulates various physiological functions including bone metabolism. These data suggest that the abnormal regulation of melatonin in outer space may contribute to pathophysiological conditions of astronauts. In addition, experiments with high-linear energy transfer radiation, a ground-based model of space radiation, showed that melatonin may serve as a protectant against space radiation. Gene expression profiling using an in vitro culture model exposed to space flight during the STS-132 mission, showed that space radiation alters the expression of DNA repair and oxidative stress response genes, indicating that melatonin counteracts the expression of these genes responsive to space radiation to promote cell survival. These findings implicate the use of exogenous melatonin and the regulation of endogenous melatonin as countermeasures for the physiological consequences of space flight. This article is protected by copyright. All rights reserved.

      DOI： 10.1111/jpi.12834

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    • Functional analysis of a matrix peptide involved in calcification of the exoskeleton of the kuruma prawn, Marsupenaeus japonicus

      Aika Sekimoto, Tsuyoshi Ohira, Atsushi Shigematsu, Takuji Okumura, Miyuki Mekuchi, Kenji Toyota, Hiroyuki Mishima, Ryoya Kawamura, Kaito Hatano, Umi Kawago, Yoichiro Kitani, Toshio Sekiguchi, Thumronk Amornsakun, Jun Hirayama, Atsuhiko Hattori, Hajime Matsubara, Nobuo Suzuki

      Aquaculture   738437 - 738437   6 2022

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      Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

      DOI： 10.1016/j.aquaculture.2022.738437

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    • Osteoclastic and Osteoblastic Responses to Hypergravity and Microgravity: Analysis Using Goldfish Scales as a Bone Model

      Tatsuki Yamamoto, Mika Ikegame, Yukihiro Furusawa, Yoshiaki Tabuchi, Kaito Hatano, Kazuki Watanabe, Umi Kawago, Jun Hirayama, Sachiko Yano, Toshio Sekiguchi, Kei-ichiro Kitamura, Masato Endo, Arata Nagami, Hajime Matsubara, Yusuke Maruyama, Atsuhiko Hattori, Nobuo Suzuki

      Zoological Science39 ( 4 )   5 4 2022

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      Publishing type：Research paper (scientific journal)   Publisher：Zoological Society of Japan  

      DOI： 10.2108/zs210107

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    • Hydroxylated benzo[c]phenanthrene metabolites cause osteoblast apoptosis and skeletal abnormalities in fish

      Nobuo Suzuki, Masato Honda, Masayuki Sato, Shuhei Yoshitake, Kimi Kawabe, Yoshiaki Tabuchi, Toshiki Omote, Toshio Sekiguchi, Yukihiro Furusawa, Akira Toriba, Ning Tang, Yohei Shimasaki, Edward G. Nagato, Lulu Zhang, Ajai K. Srivastav, Thumronk Amornsakun, Yoichiro Kitani, Hajime Matsubara, Takashi Yazawa, Jun Hirayama, Atsuhiko Hattori, Yuji Oshima, Kazuichi Hayakawa

      Ecotoxicology and Environmental Safety234   113401 - 113401   4 2022

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      DOI： 10.1016/j.ecoenv.2022.113401

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    • Activation of RANKL-producing cells under simulated microgravity with a three-dimensional clinostat in regenerating goldfish scales

      Tatsuki Yamamoto, Mika Ikegame, Kohei Kuroda, Jingjing Kobayashi-Sun, Jun Hirayama, Isao Kobayashi, Ryoya Kawamura, Masato Endo, Yoshiaki Tabuchi, Yukihiro Furusawa, Koji Yachiguchi, Toshio Sekiguchi, Hajime Matsubara, Sachiko Yano, Atsuhiko Hattori, Nobuo Suzuki

      Biological Sciences in Space36   9 - 14   2022

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      DOI： 10.2187/bss.36.9

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    • Oral administration of melatonin increases plasma calcium and magnesium and improves bone metabolism in aged male mice

      Junko Igarashi-Migitaka, Yusuke Maruyama, Azusa Seki, Jun Hirayama, Atsuko Kamijo-Ikemori, Kazuaki Hirata, Ryoya Kawamura, Hajime Matsubara, Ajai K Srivastav, Yoshiaki Tabuchi, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki

      Melatonin Research4 ( 4 ) 581 - 591   31 12 2021

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      We previously reported that the oral administration of melatonin from 4 to 20 months to male mice improved femoral bone strength and bone density during the aging. Additionally, melatonin receptor, MT2, was immunologically detected in both osteoblasts and osteoclasts of the mouse femoral bone. Thus, melatonin can act on both osteoblasts and osteoclasts to maintain bone strength during the aging process. Here, we analyzed plasma calcium (Ca2+), magnesium (Mg2+), and inorganic phosphorus ([PO4]3-) in 20-month-old male mice with or without administration melatonin (15-20 mg/kg/day) in drinking water. We found that plasma Ca2+ and Mg2+ levels in melatonin-treated mice increased significantly as compared with control mice. In [PO4]3-, melatonin administration tended to increase its plasma level, but did not reach statistical significance. The potential association between these divalent ions and metabolism markers of femoral bone was also examined. In the femoral diaphysis, the plasma Ca2+ and Mg2+ concentrations were positively correlated with periosteal and endosteal circumference which were significantly associated with the Strength Strain Index. Therefore, melatonin treatment enlarged femoral diaphysis and enhanced bone strength by increasing mineral depositions. In addition, the plasma melatonin levels were significantly positive correlation with total bone density and critical thickness in the femoral diaphysis. Since we had not observed the primary trabecular bone and osteoclasts in 20-month-old mice previously, it is suggested that plasma Ca2+ and Mg2+ are not elevated due to bone resorption. The increased plasma Ca2+ and Mg2+ by melatonin may originate from the intestinal absorption of these ions since melatonin binds to the vitamin D3 receptor, its activation is known to promote the intestinal absorption of Ca2+.

      DOI： 10.32794/mr112500113

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    • Association between Dietary Melatonin Intake and Total and Cause-Specific Mortality in Japanese Adults in the Takayama Study Peer-reviewed

      Chisato Nagata, Keiko Wada, Michiyo Yamakawa, Yuma Nakashima, Sachi Koda, Takahiro Uji, Sakiko Onuma, Shino Oba, Yuuske Maruyama, Atsuhiko Hattori

      American Journal of Epidemiology   8 2021

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      <title>Abstract</title>
      Potential health benefits of melatonin have been suggested. Although melatonin is present in various foods, little is known about the health effects of dietary melatonin intake. We estimated habitual dietary melatonin intake and examined its association with total and cause-specific mortality in a population-based cohort study in Japan. Study subjects included 13,355 men and 15,724 women aged ≥35 years who responded to a self-administered questionnaire in 1992. Their diets were assessed via a food frequency questionnaire at baseline. The melatonin content in various foods on the questionnaire was measured to estimate melatonin intake. Mortality was ascertained during 16 years of follow-up (1992–2008). Hazard ratios (HRs) and 95% confidence intervals (CIs) for total and cause-specific mortality were calculated according to melatonin quartiles. A total of 5,339 deaths occurred during follow-up. Melatonin intake was significantly associated with decreased risks of total mortality, cardiovascular mortality, and noncancer, noncardiovascular mortality after controlling for covariates; HRs for the highest quartile of melatonin intake versus the lowest were 0.90 (95% CI: 0.82, 0.98; P for trend = 0.05), 0.85 (95% CI: 0.72, 0.99; P for trend = 0.10), and 0.77 (95% CI: 0.67, 0.90; P for trend = 0.003), respectively. The data suggest a potential benefit of dietary melatonin with regard to mortality rates.

      DOI： 10.1093/aje/kwab213

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    • Effects of antioxidant in adjunct with periodontal therapy in patients with type 2 diabetes: A systematic review and meta-analysis

      Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata

      Antioxdants10 ( 8 ) e1304   8 2021

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    • Glyoxal-induced formation of advancedglycation end-products in type 1 collagen decreases both its strength and flexibilityi n vitro Peer-reviewed

      Kei-ichiro Kitamura, Jun Hirayama, Yoshiaki Tabuchi, Takao Minami, Hajime Matsubara, Atsuhiko Hattori, Nobuo Suzuki

      Journal of Diabetes Investigation   2 2021

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      The high plasma glucose induced in glucose metabolism disorders leads to the non-enzymatic glucose-dependent modification (glycation) of type 1 collagen, which is an essential component of bone tissue. The glycation of proteins induces the formation of advanced glycation end-products, such as carboxymethyl arginine, which is preferentially generated in glycated collagen. However, the effect of advanced glycation end-product formation on the characteristics of type 1 collagen remains unclear due to the lack of suitable in vitro experimental systems analyzing type 1 collagen. Here, we show that the glycation of type 1 collagen can be analyzed in vitro using a goldfish-scale bone model. Our study using these scales provides evidence that the advanced glycation end-product formation in type 1 collagen induced by glyoxal, the carboxymethyl arginine inducer, facilitates the crosslinking of type 1 collagen, decreasing both its strength and flexibility.

      DOI： 10.1111/jdi.13528

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    • In Vivo Suppression of Osteoclastic and Osteoblastic Activities of Goldfish Scales in Water Containing Cadmium

      Nobuo Suzuki, Umi Kawago, Masato Honda, Ajai K. Srivastav, Thumronk Amornsakun, Kyoko Matsumoto, Jun Hirayama, Hajime Matsubara, Nobuaki Shimizu, Toshio Sekiguchi, Yuichi Sasayama, Yoshiaki Tabuchi, Atsuhiko Hattori, Yohei Shimasaki, Yuji Oshima

      JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY66 ( 2 ) 199 - 203   2021

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      DOI： 10.15017/4486551

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    • The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice. Peer-reviewed

      Hikaru Iwashita, Yukihisa Matsumoto, Yusuke Maruyama, Kazuki Watanabe, Atsuhiko Chiba, Atsuhiko Hattori

      J Pineal Res70 ( 1 ) e12703 - e12703   1 2021

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      Melatonin (MEL) has been reported to enhance cognitive processes, making it a potential treatment for cognitive decline. However, the role of MEL's metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in these effects are unknown. The current study directly investigated the acute effects of systemic MEL, AFMK, and AMK on novel object recognition. We also analyzed MEL, AFMK, and AMK levels in hippocampus and temporal lobe containing the perirhinal cortex following systemic MEL and AMK treatment. AMK administered post-training had a more potent effect on object memory than MEL and AFMK. AMK was also able to rescue age-associated declines in memory impairments when object memory was tested up to 4 days following training. Results from administering AMK at varying times around the training trial and the metabolism time course in brain tissue suggest that AMK's memory-enhancing effects reflect memory consolidation. Furthermore, inhibiting the MEL-to-AMK metabolic pathway disrupted object memory at 24 hours post-training, suggesting that endogenous AMK might play an important role in long-term memory formation. This is the first study to report that AMK facilitates long-term object memory performance in mice, and that MEL crosses the blood-brain barrier and is immediately converted to AMK in brain tissue. Overall, these results support AMK as a potential therapeutic agent to improve or prevent memory decline.

      DOI： 10.1111/jpi.12703

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      Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jpi.12703

    • Expression of sclerostin in the regenerating scales of goldfish and its increase under microgravity during space flight. Peer-reviewed

      Tatsuki Yamamoto, Mika Ikegame, Jun Hirayama, Kei-Ichiro Kitamura, Yoshiaki Tabuchi, Yukihiro Furusawa, Toshio Sekiguchi, Masato Endo, Hiroyuki Mishima, Azusa Seki, Sachiko Yano, Hajime Matsubara, Atsuhiko Hattori, Nobuo Suzuki

      Biomed Res41 ( 6 ) 279 - 288   11 2020

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      Osteocytes, osteoblasts (bone-forming cells), and osteoclasts (bone-resorbing cells) are the primary types of cells that regulate bone metabolism in mammals. Sclerostin produced in bone cells activates osteoclasts, inhibiting bone formation; excess production of sclerostin, therefore, leads to the loss of bone mass. Fish scales have been reported to have morphological and functional similarities to mammalian bones, making them a useful experimental system for analyzing vertebrate bone metabolism in vitro. However, whether fish scales contain cells producing sclerostin and/or osteocytes has not been determined. The current study demonstrated, for the first time, that sclerostin-containing cells exist in goldfish scales. Analysis of the distribution and shape of sclerostin-expressing cells provided evidence that osteoblasts produce sclerostin in goldfish scales. Furthermore, our results found that osteocyte-like cells exist in goldfish scales, which also produce sclerostin. Finally, we demonstrated that microgravity in outer space increased the level of sclerostin in the scales of goldfish, a finding suggesting that the induction of sclerostin is the mechanism underlying the activation of osteoclasts under microgravity.

      DOI： 10.2220/biomedres.41.279

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    • Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota International journal

      Watanabe Kazuki, Katagiri Sayaka, Takahashi Hirokazu, Sasaki Naoki, Maekawa Shogo, Komazaki Rina, Hatasa Masahiro, Kitajima Yoichiro, Maruyama Yusuke, Shiba Takahiko, Komatsu Keiji, Ohsugi Yujin, Tanaka Kenichi, Matsuzawa Ayumi, Hirota Tomomitsu, Tohara Haruka, Eguchi Yuichiro, Anzai Keizo, Hattori Atsuhiko, Iwata Takanori

      FASEB JOURNAL35 ( 2 ) e21171   11 2020

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      Skeletal muscles have a high metabolic capacity, which play key roles in glucose metabolism. Although periodontal disease increases the risk of metabolic syndrome, the relationship between periodontal bacterial infection and skeletal muscle metabolic dysfunction is unclear. We found that anti-Porphyromonas gingivalis (Pg) antibody titers positively correlated with intramuscular adipose tissue content (IMAC), fasting blood glucose, and HOMA-IR in metabolic syndrome patients. In C57BL/6J mice fed a high-fat diet, recipients of oral Pg (HFPg) had impaired glucose tolerance, insulin resistance, and higher IMAC compared to recipients of saline (HFco). The soleus muscle in HFPg mice exhibited fat infiltration and lower glucose uptake with higher Tnfa expression and lower insulin signaling than in HFco mice. Gene set enrichment analysis showed that TNFα signaling via NFκB gene set was enriched in the soleus muscle of HFPg mice. Moreover, TNF-α also decreased glucose uptake in C2C12 myoblast cells in vitro. Based on 16S rRNA sequencing, Pg administration altered the gut microbiome, particularly by decreasing the abundance of genus Turicibacter. Microbial network of the gut microbiome was dramatically changed by Pg administration. Our findings suggest that infection with Pg is a risk factor for metabolic syndrome and skeletal muscle metabolic dysfunction via gut microbiome alteration.

      DOI： 10.1096/fj.202001158R

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    • De novo transcriptome analysis and gene expression profiling of fish scales isolated from Carassius auratus during space flight: Impact of melatonin on gene expression in response to space radiation. Peer-reviewed International journal

      Yukihiro Furusawa, Tatsuki Yamamoto, Atsuhiko Hattori, Nobuo Suzuki, Jun Hirayama, Toshio Sekiguchi, Yoshiaki Tabuchi

      Mol Med Rep22 ( 4 ) 2627 - 2636   10 2020

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      Astronauts are inevitably exposed to two major risks during space flight, microgravity and radiation. Exposure to microgravity has been discovered to lead to rapid and vigorous bone loss due to elevated osteoclastic activity. In addition, long‑term exposure to low‑dose‑rate space radiation was identified to promote DNA damage accumulation that triggered chronic inflammation, resulting in an increased risk for bone marrow suppression and carcinogenesis. In our previous study, melatonin, a hormone known to regulate the sleep‑wake cycle, upregulated calcitonin expression levels and downregulated receptor activator of nuclear factor‑κB ligand expression levels, leading to improved osteoclastic activity in a fish scale model. These results indicated that melatonin may represent a potential drug or lead compound for the prevention of bone loss under microgravity conditions. However, it is unclear whether melatonin affects the biological response induced by space radiation. The aim of the present study was to evaluate the effect of melatonin on the expression levels of genes responsive to space radiation. In the present study, to support the previous data regarding de novo transcriptome analysis of goldfish scales, a detailed and improved experimental method (e.g., PCR duplicate removal followed by de novo assembly, global normalization and calculation of statistical significance) was applied for the analysis. In addition, the transcriptome data were analyzed via global normalization, functional categorization and gene network construction to determine the impact of melatonin on gene expression levels in irradiated fish scales cultured in space. The results of the present study demonstrated that melatonin treatment counteracted microgravity‑ and radiation‑induced alterations in the expression levels of genes associated with DNA replication, DNA repair, proliferation, cell death and survival. Thus, it was concluded that melatonin may promote cell survival and ensure normal cell proliferation in cells exposed to space radiation.

      DOI： 10.3892/mmr.2020.11363

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    • Melatonin suppresses both osteoblast and osteoclast differentiation through repression of epidermal Erk signaling in the zebrafish scale. Peer-reviewed International journal

      Jingjing Kobayashi-Sun, Nobuo Suzuki, Atsuhiko Hattori, Masaaki Yamaguchi, Isao Kobayashi

      Biochem Biophys Res Commun530 ( 4 ) 644 - 650   10 2020

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      Melatonin has been implicated in the regulation of bone metabolism; however, the molecular mechanisms underlying its involvement in fracture healing are still obscure. We previously developed an in vivo fracture healing model using the scale of a double-transgenic zebrafish, trap:GFP; osterix:mCherry, which labels osteoclasts and osteoblasts with GFP and mCherry, respectively. Here we show using this model that melatonin inhibits both osteoblast and osteoclast differentiation under fracture stress through the repression of Erk signaling in epidermal cells of the scale. Melatonin treatment resulted in reduced numbers of both osteoblasts and osteoclasts in the fractured scale. Immunochemistry analysis revealed that Erk signals in epidermal cells, which express melatonin receptors, were greatly enhanced in response to fracture stress, but this enhancement was blocked by melatonin treatment. Moreover, inhibition of Erk signaling phenocopied the effects of melatonin treatment in the fractured scale. Collectively, these data suggest that the activation of epidermal Erk signaling is required for both osteoblast and osteoclast differentiation in the early stage of fracture healing, and melatonin suppresses epidermal Erk signaling, leading to impaired fracture healing.

      DOI： 10.1016/j.bbrc.2020.07.075

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    • Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice. Peer-reviewed International journal

      Junko Igarashi-Migitaka, Azusa Seki, Mika Ikegame, Masato Honda, Toshio Sekiguchi, Hiroyuki Mishima, Nobuaki Shimizu, Hajime Matsubara, Ajai K Srivastav, Jun Hirayama, Yusuke Maruyama, Atsuko Kamijo-Ikemori, Kazuaki Hirata, Atsuhiko Hattori, Nobuo Suzuki

      Acta Histochem122 ( 6 ) 151596 - 151596   9 2020

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      Melatonin has recently been found to be a possible new regulator of bone metabolism. However, the influence of melatonin in natural age-related osteoporosis has not been fully elucidated yet, although there have been some reports regarding postmenopausal osteoporosis with melatonin treatments. The present study investigated the effects of long-term melatonin administration during the aging process on bone metabolism. Using quantitative computed tomography methods, we found that the total bone density of both the femur metaphysis and diaphysis decreased significantly in 20-month-old male mice. In the metaphysis, both trabecular bone mass and Polar-Strength Strain Index (SSI), which is an index of bone strength, decreased significantly. Judging from bone histomorphometry analysis, trabecular bone in 20-month-old male mice decreases significantly with age and is small and sparse, as compared to that of 4-month-old male mice. Loss of trabecular bone is one possible cause of loss of bone strength in the femoral bone. In the metaphysis, the melatonin administration group had significantly higher trabecular bone density than the non-administration group. The Polar-SSI, cortical area, and periosteal circumference in the diaphysis was also significantly higher with melatonin treatments. Since the melatonin receptor, MT2, was detected in both osteoblasts and osteoclasts of the femoral bone of male mice, we expect that melatonin acts on osteoblasts and osteoclasts to maintain the bone strength of the diaphysis and metaphysis. Thus, melatonin is a potential drug for natural age-related osteoporosis.

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    • Detection of RANKL- producing cells and osteoclastic activation by the addition of exogenous RANKL in the regenerating scales of goldfish. Peer-reviewed

      YYamamoto T, Ikegame M, Kawago U, Tabuchi Y, Hirayama J, Sekiguchi T, Furusawa Y, Yachiguchi K, Matsubara H, Urata M, Hattori A, Suzuki N

      Bio. Sci. Space34   34 - 40   8 2020

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      DOI： 10.2187/bss.34.34

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    • Uptake of osteoblast-derived extracellular vesicles promotes the differentiation of osteoclasts in the zebrafish scale. Peer-reviewed International journal

      Jingjing Kobayashi-Sun, Shiori Yamamori, Mao Kondo, Junpei Kuroda, Mika Ikegame, Nobuo Suzuki, Kei-Ichiro Kitamura, Atsuhiko Hattori, Masaaki Yamaguchi, Isao Kobayashi

      Communications biology3 ( 1 ) 190 - 190   23 4 2020

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      Differentiation of osteoclasts (OCs) from hematopoietic cells requires cellular interaction with osteoblasts (OBs). Due to the difficulty of live-imaging in the bone, however, the cellular and molecular mechanisms underlying intercellular communication involved in OC differentiation are still elusive. Here, we develop a fracture healing model using the scale of trap:GFP; osterix:mCherry transgenic zebrafish to visualize the interaction between OCs and OBs. Transplantation assays followed by flow cytometric analysis reveal that most trap:GFPhigh OCs in the fractured scale are detected in the osterix:mCherry+ fraction because of uptake of OB-derived extracellular vesicles (EVs). In vivo live-imaging shows that immature OCs actively interact with osterix:mCherry+ OBs and engulf EVs prior to convergence at the fracture site. In vitro cell culture assays show that OB-derived EVs promote OC differentiation via Rankl signaling. Collectively, these data suggest that EV-mediated intercellular communication with OBs plays an important role in the differentiation of OCs in bone tissue.

      DOI： 10.1038/s42003-020-0925-1

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    • Influence of Benz[a]anthracene on Bone Metabolism and on Liver Metabolism in Nibbler Fish, Girella punctata. Peer-reviewed International journal

      Mohamed I Zanaty, Niina Sawada, Yoichiro Kitani, Hossam F Nassar, Hamada M Mahmoud, Kazuichi Hayakawa, Toshio Sekiguchi, Shouzo Ogiso, Yoshiaki Tabuchi, Makoto Urata, Hajime Matsubara, Yutaka Takeuchi, Atsuhiko Hattori, Ajai K Srivastav, Thumronk Amornsakun, Nobuo Suzuki

      International journal of environmental research and public health17 ( 4 )   21 2 2020

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      It has been reported that spinal deformity was induced in developing fish by the addition of polycyclic aromatic hydrocarbons (PAHs). To examine the mechanism of the disruption of fish bone metabolism, the effect of benz[a]anthracene (BaA), a kind of PAH, on plasma calcium, inorganic phosphorus, osteoblasts, and osteoclasts was investigated in this study. We also measured several plasma components to analyze the toxicity of BaA on other metabolisms. BaA (1 or 10 ng/g body weight) was intraperitoneally injected (four times) into nibbler fish during breeding, for 10 days, and it was indicated, for the first time, that injecting high doses of BaA to nibbler fish induced both hypocalcemia and hypophosphatemia. Furthermore, in the scales of nibbler fish treated with high doses of BaA, both osteoclastic and osteoblastic marker messengerRNA (mRNA) expressions decreased. These results are a cause of disruption of bone metabolism and, perhaps, the induction of spinal deformities. In addition, we found that total protein, metabolic enzymes in the liver, total cholesterol, free cholesterol, and high-density lipoprotein cholesterol levels significantly decreased in BaA-injected fish. These results indicate that BaA may affect liver diseases and emphasize the importance of prevention of aquatic PAH pollution.

      DOI： 10.3390/ijerph17041391

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    • The Use of Chemical Compounds to Identify the Regulatory Mechanisms of Vertebrate Circadian Clocks. Peer-reviewed International journal

      Yoshimi Okamoto-Uchida, Akari Nishimura, Junko Izawa, Atsuhiko Hattori, Nobuo Suzuki, Jun Hirayama

      Current drug targets21 ( 5 ) 425 - 432   2020

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      Circadian clocks are intrinsic, time-tracking processes that confer a survival advantage on an organism. Under natural conditions, they follow approximately a 24-h day, modulated by environmental time cues, such as light, to maximize an organism's physiological efficiency. The exact timing of this rhythm is established by cell-autonomous oscillators called cellular clocks, which are controlled by transcription-translation negative feedback loops. Studies of cell-based systems and wholeanimal models have utilized a pharmacological approach in which chemical compounds are used to identify molecular mechanisms capable of establishing and maintaining cellular clocks, such as posttranslational modifications of cellular clock regulators, chromatin remodeling of cellular clock target genes' promoters, and stability control of cellular clock components. In addition, studies with chemical compounds have contributed to the characterization of light-signaling pathways and their impact on the cellular clock. Here, the use of chemical compounds to study the molecular, cellular, and behavioral aspects of the vertebrate circadian clock system is described.

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    • Melatonin is a potential drug for the prevention of bone loss during space flight Peer-reviewed

      Mika Ikegame, Atsuhiko Hattori, Makoto J. Tabata, Kei ichiro Kitamura, Yoshiaki Tabuchi, Yukihiro Furusawa, Yusuke Maruyama, Tatsuki Yamamoto, Toshio Sekiguchi, Risa Matsuoka, Taizo Hanmoto, Takahiro Ikari, Masato Endo, Katsunori Omori, Masaki Nakano, Sayaka Yashima, Sadakazu Ejiri, Toshiki Taya, Hiroshi Nakashima, Nobuaki Shimizu, Masahisa Nakamura, Takashi Kondo, Kazuichi Hayakawa, Ichiro Takasaki, Atsushi Kaminishi, Ryosuke Akatsuka, Yuichi Sasayama, Takumi Nishiuchi, Masayuki Nara, Hachiro Iseki, Vishwajit S. Chowdhury, Shigehito Wada, Kenichi Ijiri, Toshio Takeuchi, Tohru Suzuki, Hironori Ando, Kouhei Matsuda, Masanori Somei, Hiroyuki Mishima, Yuko Mikuni-Takagaki, Hisayuki Funahashi, Akihisa Takahashi, Yoshinari Watanabe, Masahiro Maeda, Hideaki Uchida, Akio Hayashi, Akira Kambegawa, Azusa Seki, Sachiko Yano, Toru Shimazu, Hiromi Suzuki, Jun Hirayama, Nobuo Suzuki

      Journal of Pineal Research67 ( 3 )   1 10 2019

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      DOI： 10.1111/jpi.12594

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    • Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms Peer-reviewed International journal

      Norihiro Nagai, Masahiko Ayaki, Tatsuo Yanagawa, Atsuhiko Hattori, Kazuno Negishi, Takuro Mori, Takahiro J. Nakamura, Kazuo Tsubota

      Invest Ophthalmol Vis Sci60 ( 12 ) 3786 - 3793   9 2019

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      Purpose: Light-emitting diodes that emit high-intensity blue light are associated with blue-light hazard. Here, we report that blue light disturbs circadian rhythms by interfering with the clock gene in the suprachiasmatic nucleus (SCN) and that suppression of blue light at night ameliorates metabolic abnormalities by controlling circadian rhythms. Methods: C57BL/6J mice were exposed to 10-lux light for 30 minutes at Zeitgeber time 14 for light pulse with blue light or blue-light cut light to induce phase shift of circadian rhythms. Phase shift, clock gene expression in SCN, and metabolic parameters were analyzed. In the clinical study, healthy participants wore blue-light shield eyewear for 2 to 3 hours before bed. Anthropometric data analyses, laboratory tests, and sleep quality questionnaires were performed before and after the study. Results: In mice, phase shift induced with a blue-light cut light pulse was significantly shorter than that induced with a white light pulse. The phase of Per2 expression in the SCN was also delayed after a white light pulse. Moreover, blood glucose levels 48 hours after the white light pulse were higher than those after the blue-cut light pulse. Irs2 expression in the liver was decreased with white light but significantly recovered with the blue-cut light pulse. In a clinical study, after 1 month of wearing blue-light shield eyeglasses, there were improvements in fasting plasma glucose levels, insulin resistance, and sleep quality. Conclusions: Our results suggest that suppression of blue light at night effectively maintains circadian rhythms and metabolism.

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    • Development of a system for measuring calcitonin in the stingray Dasyatis akajei (a cartilaginous fish): the possible involvement of stingray calcitonin in gonadal development Peer-reviewed

      Takashi Takagi, Toshio Sekiguchi, Yuichi Sasayama, Atsuhiko Hattori, Takushi X. Watanabe, Yoichiro Kitani, Yoshiaki Tabuchi, Hajime Matsubara, Ajai K. Srivastav, Tran Ngoc Hai, Thumronk Amornsakun, Nobuo Suzuki

      International Aquatic Research11 ( 3 ) 267 - 276   1 9 2019

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      DOI： 10.1007/s40071-019-00236-0

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    • Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates. Peer-reviewed International journal

      Yoshimi Okamoto-Uchida, Junko Izawa, Akari Nishimura, Atsuhiko Hattori, Nobuo Suzuki, Jun Hirayama

      Current genomics20 ( 5 ) 332 - 339   8 2019

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      Circadian clocks are intrinsic, time-tracking systems that bestow upon organisms a survival advantage. Under natural conditions, organisms are trained to follow a 24-h cycle under environmental time cues such as light to maximize their physiological efficiency. The exact timing of this rhythm is established via cell-autonomous oscillators called cellular clocks, which are controlled by transcription/translation-based negative feedback loops. Studies using cell-based systems and genetic techniques have identified the molecular mechanisms that establish and maintain cellular clocks. One such mechanism, known as post-translational modification, regulates several aspects of these cellular clock components, including their stability, subcellular localization, transcriptional activity, and interaction with other proteins and signaling pathways. In addition, these mechanisms contribute to the integration of external signals into the cellular clock machinery. Here, we describe the post-translational modifications of cellular clock regulators that regulate circadian clocks in vertebrates.

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    • Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin Peer-reviewed

      Masaki Nakano, Mika Ikegame, Junko Igarashi-Migitaka, Yusuke Maruyama, Nobuo Suzuki, Atsuhiko Hattori

      The Journal of endocrinology242 ( 2 ) 13 - 23   1 8 2019

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    • Effect of mats with “A Distinctive 4-Layer 3 -Dimensional Structure” on sleep quality and nocturnal blood glucose: A crossover trial. Peer-reviewed

      Mari Ogura, Atsuhiko Hattori, Masayuki Yagi, Wakako Takabe, Takuto Nonomura, Yoji Shimura, Midori Ando, Yoshikazu Yonei

      Glycative Stress Research6 ( 1 )   3 2019

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      DOI： 10.24659/gsr.6.1_049

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    • Circadian production of melatonin in cartilage modifies rhythmic gene expression. Peer-reviewed

      Fu S, Kuwahara M, Uchida Y, Koudo S, Hayashi D, Shimomura Y, Takagaki A, Nishida T, Maruyama Y, Ikegame M, Hattori A, Kubota S, Hattori T

      Journal of Endocrinology241 ( 2 ) 161 - 173   3 2019

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      Endochondral ossification, including bone growth and other metabolic events, is regulated by circadian rhythms. Herein, we provide evidence that melatonin has a direct effect on the circadian rhythm of chondrocytes. We detected mRNA expression of the genes which encode the melatonin-synthesizing enzymes AANAT (arylalkylamine N-acetyltransferase) and HIOMT (hydroxyindole O-methyltransferase), as well as the melatonin receptors MT1 and MT2 in mouse primary chondrocytes and cartilage. Production of melatonin was confirmed by mass spectrometric analysis of primary rat and chick chondrocytes. Addition of melatonin to primary BALB/c mouse chondrocytes caused enhanced cell growth and increased expression of <italic>Col2a1</italic>, <italic>Aggrecan</italic> and <italic>Sox9</italic>, but inhibited <italic>Col10a1</italic> expression. Addition of luzindole, an MT1 and MT2 antagonist, abolished these effects. These data indicate that chondrocytes produce melatonin, which regulates cartilage growth and maturation via the MT1 and MT2 receptors. Kinetic analysis showed that melatonin caused rapid upregulation of <italic>Aanat</italic>, <italic>Mt1</italic>, <italic>Mt2</italic> and <italic>Pthrp</italic> expression, followed by <italic>Sox9</italic> and <italic>Ihh</italic>. Furthermore, expression of the clock gene <italic>Bmal1</italic> was induced, while that of <italic>Per1</italic> was downregulated. Chronobiological analysis of synchronized C3H mouse chondrocytes revealed that melatonin induced the cyclic expression of <italic>Aanat</italic> and modified the cyclic rhythm of <italic>Bmal1</italic>, <italic>Mt1</italic> and <italic>Mt2</italic>. In contrast, <italic>Mt1</italic> and <italic>Mt2</italic> showed different rhythms from <italic>Bmal1</italic> and <italic>Aanat</italic>, indicating the existence of different regulatory genes. Our results indicate that exogenous and endogenous melatonin work in synergy in chondrocytes to adjust rhythmic expression to the central suprachiasmatic nucleus clock.

      DOI： 10.1530/JOE-19-0022

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    • Influence of Polluted Sea Water in the Red Sea on the Osteoclasts and Osteoblasts of Goldfish, Carassius auratus

      Mohamed Zanaty, Hossam F. Nassar, Hamada M. Mahmoud, Fagr Kh Abdel-Gawad, Masayuki Sato, Koji Yachiguchi, Nobuaki Shimizu, Kazuichi Hayakawa, Atsuhiko Hattori, Koki Mukai, Yohei Shimasaki, Yuji Oshima, Nobuo Suzuki

      JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY64 ( 2 ) 287 - 291   2019

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    • The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish. Peer-reviewed International journal

      Hirayama J, Alifu Y, Hamabe R, Yamaguchi S, Tomita J, Maruyama Y, Asaoka Y, Nakahama KI, Tamaru T, Takamatsu K, Takamatsu N, Hattori A, Nishina S, Azuma N, Kawahara A, Kume K, Nishina H

      Scientific Reports9 ( 1 ) 196 - 196   1 2019

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      The circadian clock generates behavioral rhythms to maximize an organism's physiological efficiency. Light induces the formation of these rhythms by synchronizing cellular clocks. In zebrafish, the circadian clock components Period2 (zPER2) and Cryptochrome1a (zCRY1a) are light-inducible, however their physiological functions are unclear. Here, we investigated the roles of zPER2 and zCRY1a in regulating locomotor activity and behavioral rhythms. zPer2/zCry1a double knockout (DKO) zebrafish displayed defects in total locomotor activity and in forming behavioral rhythms when briefly exposed to light for 3-h. Exposing DKO zebrafish to 12-h light improved behavioral rhythm formation, but not total activity. Our data suggest that the light-inducible circadian clock regulator zCRY2a supports rhythmicity in DKO animals exposed to 12-h light. Single cell imaging analysis revealed that zPER2, zCRY1a, and zCRY2a function in synchronizing cellular clocks. Furthermore, microarray analysis of DKO zebrafish showed aberrant expression of genes involved regulating cellular metabolism, including ATP production. Overall, our results suggest that zPER2, zCRY1a and zCRY2a help to synchronize cellular clocks in a light-dependent manner, thus contributing to behavioral rhythm formation in zebrafish. Further, zPER2 and zCRY1a regulate total physical activity, likely via regulating cellular energy metabolism. Therefore, these circadian clock components regulate the rhythmicity and amount of locomotor behavior.

      DOI： 10.1038/s41598-018-37879-8

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    • RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales Peer-reviewed

      Yuya Tazaki, Kayo Sugitani, Kazuhiro Ogai, Isao Kobayashi, Haruki Kawasaki, Takafumi Aoyama, Nobuo Suzuki, Yoshiaki Tabuchi, Atsuhiko Hattori, Kei ichiro Kitamura

      Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology225   46 - 58   11 2018

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      DOI： 10.1016/j.cbpa.2018.06.011

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    • α-Melanocyte-stimulating hormone directly increases the plasma calcitonin level and involves calcium metabolism in goldfish Peer-reviewed

      Takahiro Ikari, Yuki Kobayashi, Yoichiro Kitani, Toshio Sekiguchi, Masato Endo, Akira Kambegawa, Kiyoshi Asahina, Atsuhiko Hattori, Yoshiaki Tabuchi, Thumronk Amornsakun, Kanta Mizusawa, Akiyoshi Takahashi, Nobuo Suzuki

      International Aquatic Research10 ( 3 ) 283 - 292   1 9 2018

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      DOI： 10.1007/s40071-018-0206-5

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    • Effect of melatonin intake on postprandial blood glucose in the breakfast Peer-reviewed

      Mari Ogura, Fuka Okuda, Atsuhiko Hattori, Wakako Takabe, Masayuki Yagi, Yoshikazu Yonei

      Glycative Stress Research5 ( 2 )   6 2018

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    • Sequencing and expression analysis of calcitonin receptor in the scales of goldfish (Carassius auratus) Peer-reviewed

      Ikari, T, Sekiguchi, T, Urata, M, Furusawa, Y, Ikegame, M, Kinoshita, Y, Kitamura, K, Nakabayashi, I, Horita, M, Tabuchi, Y, Hattori, A, Srivastav, A.K, Suzuki, N

      International Journal of Zoological Investigations4   1 - 10   6 2018

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    • α-Melanocyte-stimulating hormone promotes bone resorption resulting from increased osteoblastic and osteoclastic activities in goldfish. Peer-reviewed International journal

      Hidenori Ishizu, Toshio Sekiguchi, Takahiro Ikari, Kei-Ichiro Kitamura, Yoichiro Kitani, Masato Endo, Makoto Urata, Yasuko Kinoshita, Atsuhiko Hattori, Ajai K Srivastav, Hiroyuki Mishima, Kanta Mizusawa, Akiyoshi Takahashi, Nobuo Suzuki

      General and comparative endocrinology262   99 - 105   1 6 2018

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      We examined the effects of α-melanocyte-stimulating hormone (α-MSH) on bone metabolism using regenerating goldfish scales. Normally developed scales on the bodies of goldfish were removed to allow the regeneration of scales under anesthesia. Thereafter, the influence of α-MSH on the regeneration of goldfish scales was investigated in vivo. In brief, α-MSH was injected at a low dose (0.1 μg/g body weight) or a high dose (1 μg/g body weight) into goldfish every other day. Ten days after removing the scales, we collected regenerating scales and analyzed osteoblastic and osteoclastic activities as respective marker enzyme (alkaline phosphatase for osteoblasts, tartrate-resistant acid phosphatase for osteoclasts) activity in the regenerating scales as well as plasma calcium levels. At both doses, osteoblastic and osteoclastic activities in the regenerating scales increased significantly. Plasma calcium concentrations in the α-MSH-treated group (high doses) were significantly higher than those in the control group. Next, in vitro experiments were performed to confirm the results of in vivo experiments. In the cultured regenerating scales, osteoblastic and osteoclastic activities significantly increased with α-MSH (10-7 and 10-6 M) treatment. In addition, real-time PCR analysis indicated that osteoclastogenesis in α-MSH-treated scales was induced by the receptor activator of the NF-κB/receptor activator of the NF-κB ligand/osteoprotegerin pathway. Furthermore, we found that α-MSH receptors (melanocortin receptors 4 and 5) were detected in the regenerating scales. Thus, in teleosts, we are the first to demonstrate that α-MSH functions in bone metabolism and promotes bone resorption via melatonin receptors 4 and/or 5.

      DOI： 10.1016/j.ygcen.2018.03.020

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    • 新しいメラニン重合評価系を用いたプラセンタにおける美白有効成分の同定 Invited

      服部淳彦

      日本胎盤臨床医学会研究要覧 ( 22 ) 81 - 96   5 2018

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    • 睡眠とアンチエイジング メラトニンの老化抑制効果 Peer-reviewed

      服部 淳彦

      Anti-aging Science9 ( 2 ) 80 - 80   12 2017

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    • Immunoreactive Calcitonin Cells in the Nervous System of Polychaete Perinereis aibuhitensis Peer-reviewed

      Yoichi Kase, Shouzo Ogisoi, Takahiro Ikari, Toshio Sekiguchi, Yuichi Sasayama, Yoichiro Kitani, Yohei Shimasaki, Yuji Oshima, Akira Kambegawa, Yoshiaki Tabuchi, Atsuhiko Hattori, Nobuo Suzuki

      JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY62 ( 2 ) 381 - 385   9 2017

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    • Sardine procalcitonin amino-terminal cleavage peptide has a different action from calcitonin and promotes osteoblastic activity in the scales of goldfish Peer-reviewed

      Yoichi Kase, Takahiro Ikari, Toshio Sekiguchi, Masayuki Sato, Shouzo Ogiso, Tsuyoshi Kawada, Shin Matsubara, Honoo Satake, Yuichi Sasayama, Masato Endo, Kei-ichiro Kitamura, Atsuhiko Hattori, Takushi X. Watanabe, Yusuke Maruyama, Yoshinari Watanabe, Hisayuki Funahashi, Akira Kambegawa, Nobuo Suzuki

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY211   77 - 83   9 2017

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      DOI： 10.1016/j.cbpa.2017.06.007

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    • Erratum to: Sodium fluoride influences calcium metabolism resulting from the suppression of osteoclasts in the scales of nibbler fish Girella punctata (Fish Sci, 10.1007/s12562-017-1086-0)

      Masayuki Sato, Koji Yachiguchi, Keiichi Motohashi, Yukio Yaguchi, Yoshiaki Tabuchi, Yoichiro Kitani, Takahiro Ikari, Shouzo Ogiso, Toshio Sekiguchi, Tran Ngoc Hai, Do Thi Thanh Huong, Nguyen Viet Hoang, Makoto Urata, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki

      Fisheries Science83 ( 4 ) 551   1 7 2017

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      Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Tokyo  

      DOI： 10.1007/s12562-017-1092-2

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    • Sodium fluoride influences calcium metabolism resulting from the suppression of osteoclasts in the scales of nibbler fish Girella punctata Peer-reviewed

      Masayuki Sato, Koji Yachiguchi, Keiichi Motohashi, Yukio Yaguchi, Yoshiaki Tabuchi, Yoichiro Kitani, Takahiro Ikari, Shouzo Ogiso, Toshio Sekiguchi, Tran Ngoc Hai, Do Thi Thanh Huong, Nguyen Viet Hoang, Makoto Urata, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki

      FISHERIES SCIENCE83 ( 4 ) 543 - 550   7 2017

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      DOI： 10.1007/s12562-017-1086-0

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    • Benz[a]anthracene decreases plasma calcium levels resulting from influence of scale osteoclastic and osteoblastic activities in goldfish. Peer-reviewed

      Suzuki, N, Nakano, J, Kawabe, K, Toriba, A, Hayakawa, K, Tang, N, Sekiguchi, T, Tabuchi, Y, Ikegame, M, Shimizu, N, Mishima, H, Hattori, A, Srivastav, A.K, Kitani, Y

      International Journal of Zoological Investigations3   72 - 81   6 2017

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    • Calcitonin-typical suppression of osteoclastic activity by amphioxus calcitonin superfamily peptides and insights into the evolutionary conservation and diversity of their structures Peer-reviewed

      Toshio Sekiguchi, Akira Shiraishi, Honoo Satake, Kenji Kuwasako, Hiroki Takahashi, Masayuki Sato, Makoto Urata, Shuichi Wada, Masato Endo, Takahiro Ikari, Atsuhiko Hattori, Ajai K. Srivastav, Nobuo Suzuki

      GENERAL AND COMPARATIVE ENDOCRINOLOGY246   294 - 300   5 2017

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      DOI： 10.1016/j.ygcen.2017.01.004

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    • Large-scale integration in tablet screens for blue-light reduction with optimized color: The effects on sleep, sleepiness, and ocular parameters Peer-reviewed

      Masahiko Ayaki, Atsuhiko Hattori, Yusuke Maruyama, Kazuo Tsubota, Kazuno Negishi

      Cogent Biology   2 2017

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      DOI： 10.1080/23312025.2017.1294550

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    • 生体リズム同調因子メラトニンが象牙芽細胞、象牙質の構造及び石灰化機構に及ぼす影響 Peer-reviewed

      三島 弘幸, 武内 昇平, 田辺 咲貴, 服部 淳彦, 鈴木 信雄, 筧 光夫, 松本 敬, 池亀 美華, 武市 和彦, 見明 康雄

      日本再生歯科医学会誌14 ( 1 ) 5 - 17   2 2017

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    • キンギョ鱗における多核破骨細胞形成に関する形態学的研究：筋肉内自家移植鱗を用いた解析 Peer-reviewed

      池亀美香, 村楚淑恵, 国定勇希, 服部淳彦, 鈴木信雄, 山本敏男

      岡山歯学会雑誌35 ( 2 ) 37 - 42   1 2017

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    • Effects of low-intensity pulsed ultrasound on osteoclasts: Analysis with goldfish scales as a model of bone. Peer-reviewed

      Taizo Hanmoto, Yoshiaki Tabuchi, Mika Ikegame, Takashi Kondo, Kei-Ichiro Kitamura, Masato Endo, Isao Kobayashi, Hiroyuki Mishima, Toshio Sekiguchi, Makoto Urata, Azusa Seki, Sachiko Yano, Atsuhiko Hattori, Nobuo Suzuki

      Biomedical research (Tokyo, Japan)38 ( 1 ) 71 - 77   2017

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      The effects of low-intensity pulsed ultrasound (LIPUS) on osteoclastogenesis were examined using fish scales that had both osteoclasts and osteoblasts. The binding of the receptor activator of NF-κB ligand (RANKL) in osteoblasts to the receptor activator of NF-κB (RANK) in osteoclasts induced osteoclastogenesis. Therefore, we focused on RANK/RANKL signaling. After 6 h of incubation following LIPUS treatment, mRNA expression of RANKL increased significantly. Resulting from the increased RANKL mRNA level, the expression of transcription-regulating factors significantly increased after 6 h of incubation, and then the mRNA expression of functional genes was significantly up-regulated after 12 h of incubation. However, the mRNA expression of osteoprotegerin (OPG), which is known as an osteoclastogenesis inhibitory factor, also significantly increased after 6 h of incubation and tended to further increase after 12 h of incubation. At 24 h of incubation, osteoclastic functional genes' mRNA expression decreased to the level of the control. Furthermore, we performed an in vivo experiment with goldfish. Two weeks after daily LIPUS exposure, osteoclastic marker enzymes tended to decrease while osteoblastic marker enzymes were activated. The regeneration rate of the LIPUS-treated scales was significantly higher than that of the control scales. Thus, LIPUS moderately activates osteoclasts and induces bone formation.

      DOI： 10.2220/biomedres.38.71

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    • Effects of hyperglycemia on bone metabolism and bone matrix in goldfish scales Peer-reviewed

      Kei-ichiro Kitamura, Tadashi Andoh, Wakana Okesaku, Yuya Tazaki, Kazuhiro Ogai, Kayo Sugitani, Isao Kobayashi, Nobuo Suzuki, Wenxi Chen, Mika Ikegame, Atsuhiko Hattori

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY203   152 - 158   1 2017

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      DOI： 10.1016/j.cbpa.2016.09.010

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    • Sodium fluoride induces hypercalcemia resulting from the upregulation of both osteoblastic and osteoclastic activities in goldfish, Carassius auratus Peer-reviewed

      Masayuki Sato, Taizo Hanmoto, Koji Yachiguchi, Yoshiaki Tabuchi, Takashi Kondo, Masato Endo, Yoichiro Kitani, Toshio Sekiguchi, Makoto Urata, Tran Ngoc Hai, Ajai K. Srivastav, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY189   54 - 60   11 2016

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      DOI： 10.1016/j.cbpc.2016.07.006

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    • Tensile stress stimulates the expression of osteogenic cytokines/growth factors and matricellular proteins in the mouse cranial suture at the site of osteoblast differentiation. Peer-reviewed

      Mika Ikegame, Yoshiaki Tabuchi, Yukihiro Furusawa, Mariko Kawai, Atsuhiko Hattori, Takashi Kondo, Toshio Yamamoto

      Biomed. Res.37 ( 2 ) 117 - 126   10 2016

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      Language：English   Publishing type：Research paper (scientific journal)   Publisher：Biomedical Research Press  

      Mechanical stress promotes osteoblast proliferation and differentiation from mesenchymal stem cells (MSCs). Although numerous growth factors and cytokines are known to regulate this process, information regarding the differentiation of mechanically stimulated osteoblasts from MSCs in in vivo microenvironment is limited. To determine the significant factors involved in this process, we performed a global analysis of differentially expressed genes, in response to tensile stress, in the mouse cranial suture wherein osteoblasts differentiate from MSCs. We found that the gene expression levels of several components involved in bone morphogenetic protein, Wnt, and epithelial growth factor signalings were elevated with tensile stress. Moreover gene expression of some extracellular matrices (ECMs), such as cysteine rich protein 61 (Cyr61)/CCN1 and galectin-9, were upregulated. These ECMs have the ability to modulate the activities of cytokines and are known as matricellular proteins. Cyr61/CCN1 expression was prominently increased in the fibroblastic cells and preosteoblasts in the suture. Thus, for the first time we demonstrated the mechanical stimulation of Cyr61/CCN1 expression in osteogenic cells in an ex vivo system. These results suggest the importance of matricellular proteins along with the cytokine-mediated signaling for the mechanical regulation of MSC proliferation and differentiation into osteoblastic cell lineage in vivo.

      DOI： 10.2220/biomedres.37.117

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      Other Link： http://search.jamas.or.jp/link/ui/2016362875

    • Seawater Polluted with Highly Concentrated Polycyclic Aromatic Hydrocarbons Suppresses Osteoblastic Activity in the Scales of Goldfish, Carassius auratus Peer-reviewed

      Nobuo Suzuki, Masayuki Sato, Hossam F. Nassar, Fagr Kh. Abdel-Gawad, Samah M. Bassem, Koji Yachiguchi, Yoshiaki Tabuchi, Masato Endo, Toshio Sekiguchi, Makoto Urata, Atsuhiko Hattori, Hiroyuki Mishima, Youhei Shimasaki, Yuji Oshima, Chun-Sang Hong, Fumiya Makino, Ning Tang, Akira Toriba, Kazuichi Hayakawa

      ZOOLOGICAL SCIENCE33 ( 4 ) 407 - 413   8 2016

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      DOI： 10.2108/zs150211

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    • Is vaccenic acid (18:1t n-7) associated with an increased incidence of hip fracture? An explanation for the calcium paradox Peer-reviewed

      Kei Hamazaki, Nobuo Suzuki, Kei-ichiro Kitamura, Atsuhiko Hattori, Tetsuro Nagasawa, Miho Itomura, Tomohito Hamazaki

      PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS109   8 - 12   6 2016

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      DOI： 10.1016/j.plefa.2016.04.001

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    • Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound Peer-reviewed

      Nobuo Suzuki, Taizo Hanmoto, Sachiko Yano, Yukihiro Furusawa, Mika Ikegame, Yoshiaki Tabuchi, Takashi Kondo, Kei-ichiro Kitamura, Masato Endo, Toshio Yamamoto, Toshio Sekiguchi, Makoto Urata, Yuko Mikuni-Takagaki, Atsuhiko Hattori

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY195   26 - 31   5 2016

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      DOI： 10.1016/j.cbpa.2016.01.022

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    • Tensile stress stimulates the expression of osteogenic cytokines/growth factors and matricellular proteins in the mouse cranial suture at the site of osteoblast differentiation Peer-reviewed

      Ikegame Mika, Tabuchi Yoshiaki, Furusawa Yukihiro, Kawai Mariko, Hattori Atsuhiko, Kondo Takashi, Yamamoto Toshio

      BIOMEDICAL RESEARCH-TOKYO37 ( 2 ) 117 - 126   2016

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      Mechanical stress promotes osteoblast proliferation and differentiation from mesenchymal stem cells (MSCs). Although numerous growth factors and cytokines are known to regulate this process, information regarding the differentiation of mechanically stimulated osteoblasts from MSCs in in vivo microenvironment is limited. To determine the significant factors involved in this process, we performed a global analysis of differentially expressed genes, in response to tensile stress, in the mouse cranial suture wherein osteoblasts differentiate from MSCs. We found that the gene expression levels of several components involved in bone morphogenetic protein, Wnt, and epithelial growth factor signalings were elevated with tensile stress. Moreover gene expression of some extracellular matrices (ECMs), such as cysteine rich protein 61 (Cyr61)/CCN1 and galectin-9, were upregulated. These ECMs have the ability to modulate the activities of cytokines and are known as matricellular proteins. Cyr61/CCN1 expression was prominently increased in the fibroblastic cells and preosteoblasts in the suture. Thus, for the first time we demonstrated the mechanical stimulation of Cyr61/CCN1 expression in osteogenic cells in an ex vivo system. These results suggest the importance of matricellular proteins along with the cytokine-mediated signaling for the mechanical regulation of MSC proliferation and differentiation into osteoblastic cell lineage in vivo.

      DOI： 10.2220/biomedres.37.117

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    • Protective effect of blue-light shield eyewear for adults against light pollution from self-luminous devices used at night. Peer-reviewed

      Masahiko Ayaki, Atsuhiko Hattori, Yusuke Maruyama, Masaki Nakano, Michitaka Yoshimura, Momoko Kitazawa, Kazuno Negishi, Kazuo Tsubota

      Chronobiol. Int.33 ( 1 ) 134 - 139   1 2016

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      We investigated sleep quality and melatonin in 12 adults who wore blue-light shield or control eyewear 2 hours before sleep while using a self-luminous portable device, and assessed visual quality for the two eyewear types. Overnight melatonin secretion was significantly higher after using the blue-light shield (P < 0.05) than with the control eyewear. Sleep efficacy and sleep latency were significantly superior for wearers of the blue-light shield (P < 0.05 for both), and this group reported greater sleepiness during portable device use compared to those using the control eyewear. Participants rated the blue-light shield as providing acceptable visual quality.

      DOI： 10.3109/07420528.2015.1119158

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    • Monohydroxylated polycyclic aromatic hydrocarbons influence spicule formation in the early development of sea urchins (Hemicentrotus pulcherrimus) Peer-reviewed

      Nobuo Suzuki, Shouzo Ogiso, Koji Yachiguchi, Kimi Kawabe, Fumiya Maldno, Akira Toriba, Masato Kiyomoto, Toshio Sekiguchi, Yoshiaki Tabuchi, Takashi Kondo, Kei-ichiro Kitamura, Chun-Sang Hong, Ajai K. Srivastav, Yuji Oshima, Atsuhiko Hattori, Kazuichi Hayakawa

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY171   55 - 60   5 2015

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      DOI： 10.1016/j.cbpc.2015.02.004

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    • Melatonin Inhibits Embryonic Salivary Gland Branching Morphogenesis by Regulating Both Epithelial Cell Adhesion and Morphology Peer-reviewed International journal

      Obana-Koshino Aya, Ono Hitomi, Miura Jiro, Sakai Manabu, Uchida Hitoshi, Nakamura Wataru, Nohara Kanji, Maruyama Yusuke, Hattori Atsuhiko, Sakai Takayoshi

      PLOS ONE10 ( 4 ) e0119960   4 2015

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      Many organs, including salivary glands, lung, and kidney, are formed by epithelial branching during embryonic development. Branching morphogenesis occurs via either local outgrowths or the formation of clefts that subdivide epithelia into buds. This process is promoted by various factors, but the mechanism of branching morphogenesis is not fully understood. Here we have defined melatonin as a potential negative regulator or "brake" of branching morphogenesis, shown that the levels of it and its receptors decline when branching morphogenesis begins, and identified the process that it regulates. Melatonin has various physiological functions, including circadian rhythm regulation, free-radical scavenging, and gonadal development. Furthermore, melatonin is present in saliva and may have an important physiological role in the oral cavity. In this study, we found that the melatonin receptor is highly expressed on the acinar epithelium of the embryonic submandibular gland. We also found that exogenous melatonin reduces salivary gland size and inhibits branching morphogenesis. We suggest that this inhibition does not depend on changes in either proliferation or apoptosis, but rather relates to changes in epithelial cell adhesion and morphology. In summary, we have demonstrated a novel function of melatonin in organ formation during embryonic development.

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    • Novel tryptophan derivatives as potentially effective therapeutic drugs to treat bone diseases Peer-reviewed

      Suzuki, N, Somei, M, Seki, A, Sekiguchi, T, Tabuchi, Y, Mishima, H, Kase, Y, Kaminishi, A, Yachiguchi, K, Kitamura, K, Oshima, Y, Hayakawa, K, Yano, S, Hattori, A

      American Journal of Life Sciences3 ( 3-2 ) 31 - 38   3 2015

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      DOI： 10.11648/j.ajls.s.2015030302.16

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    • Ultradian oscillation in expression of four nnelatonin receptor subtype genes in the pineal gland of the grass puffer, a sennilunar-synchronized spawner, under constant darkness Peer-reviewed

      Ikegami Taro, Maruyama Yusuke, Doi Hiroyuki, Hattori Atsuhiko, Ando Hironori

      FRONTIERS IN NEUROSCIENCE9   1 2015

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      DOI： 10.3389/fnins.2015.00009

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    • Diurnal and Circadian Oscillations in Expression of Kisspeptin, Kisspeptin Receptor and Gonadotrophin-Releasing Hormone 2 Genes in the Grass Puffer, A Semilunar-Synchronised Spawner Peer-reviewed

      Ando H, Ogawa S, Shahjahan Md, Ikegami T, Doi H, Hattori A, Parhar I

      JOURNAL OF NEUROENDOCRINOLOGY26 ( 7 ) 459 - 467   7 2014

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      Language：English  

      DOI： 10.1111/jne.12165

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    • Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish Peer-reviewed

      Koji Yachiguchi, Noriko Matsumoto, Yuki Haga, Motoharu Suzuki, Chisato Matsumura, Masahiro Tsurukawa, Toshihiro Okuno, Takeshi Nakano, Kimi Kawabe, Kei-ichiro Kitamura, Akira Toriba, Kazuichi Hayakawa, Vishwajit S. Chowdhury, Masato Endo, Atsuhiko Chiba, Toshio Sekiguchi, Masaki Nakano, Yoshiaki Tabuchi, Takashi Kondo, Shigehito Wada, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki

      ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH21 ( 10 ) 6365 - 6372   5 2014

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1007/s11356-012-1347-5

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    • Effects of Inorganic Mercury and Methylmercury on Osteoclasts and Osteoblasts in the Scales of the Marine Teleost as a Model System of Bone Peer-reviewed

      Koji Yachiguchi, Toshio Sekiguchi, Masaki Nakano, Atsuhiko Hattori, Megumi Yamamoto, Kei-ichiro Kitamura, Masahiro Maeda, Yoshiaki Tabuchi, Takashi Kondo, Hiromitsu Kamauchi, Hajime Nakabayashi, Ajai K. Srivastav, Kazuichi Hayakawa, Tatsuya Sakamoto, Nobuo Suzuki

      ZOOLOGICAL SCIENCE31 ( 5 ) 330 - 337   5 2014

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.2108/zs130265

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    • Increased Prostaglandin E-2 Has a Positive Correlation with Plasma Calcium during Goldfish Reproduction Peer-reviewed

      Nobuo Suzuki, Yusuke Maruyama, Masaki Nakano, Atsuhiko Hattori, Masato Honda, Yohei Shimasaki, Toshio Sekiguchi, Hiroyuki Mishima, Shigehito Wada, Ajai K. Srivastav, Kazuichi Hayakawa, Yuji Oshima

      JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY59 ( 1 ) 97 - 101   2 2014

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    • Zebrafish scales respond differently to in vitro dynamic and static acceleration: Analysis of interaction between osteoblasts and osteoclasts Peer-reviewed

      Kitamura Kei-ichiro, Takahira Koh, Inari Masato, Satoh Yusuke, Hayakawa Kazuichi, Tabuchi Yoshiaki, Ogai Kazuhiro, Nishiuchi Takumi, Kondo Takashi, Mikuni-Takagaki Yuko, Chen Wenxi, Hattori Atsuhiko, Suzuki Nobuo

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY166 ( 1 ) 74 - 80   9 2013

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      Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

      DOI： 10.1016/j.cbpa.2013.04.023

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    • Static and Dynamic Hypergravity Responses of Osteoblasts and Osteoclasts in Medaka Scales Peer-reviewed

      Sachiko Yano, Kei-ichiro Kitamura, Yusuke Satoh, Masaki Nakano, Atsuhiko Hattori, Toshio Sekiguchi, Mika Ikegame, Hiroshi Nakashima, Katsunori Omori, Kazuichi Hayakawa, Atsuhiko Chiba, Yuichi Sasayama, Sadakazu Ejiri, Yuko Mikuni-Takagaki, Hiroyuki Mishima, Hisayuki Funahashi, Tatsuya Sakamoto, Nobuo Suzuki

      ZOOLOGICAL SCIENCE30 ( 3 ) 217 - 223   3 2013

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.2108/zsj.30.217

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    • Neuroendocrine control of lunar-synchronized spawning rhythm in grass puffer

      Hironori Ando, Taro Ikegami, Yusuke Maruyama, Md Shahjahan, Atsuhiko Hattori

      Sexual Plasticity and Gametogenesis in Fishes   17 - 29   2013

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      Language：English   Publishing type：Part of collection (book)   Publisher：Nova Science Publishers, Inc.  

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    • 象牙質の成長線の周期と体内時計の情報伝達分子のメラトニンの分泌リズムの関連 Peer-reviewed

      三島弘幸, 井上昌子, 門田理佳, 服部淳彦, 鈴木信雄, 筧 光夫, 松本敬, 里村一人, 見明康雄

      日本再生歯科医学会誌11   27 - 39   2013

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      Language：Japanese   Publishing type：Research paper (scientific journal)  

      DOI： 10.11223/jard.11.27

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    • Molecular neuroendocrine basis of lunar-related spawning in grass puffer Peer-reviewed

      Ando Hironori, Shahjahan Md, Hattori Atsuhiko

      GENERAL AND COMPARATIVE ENDOCRINOLOGY181   211 - 214   1 2013

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      DOI： 10.1016/j.ygcen.2012.07.027

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    • Determination of calcium sensing receptor in the scales of goldfish and inductionof its mRNA expression by acceleration loading Peer-reviewed

      Kakikawa M, Yamamoto T, Satoh Y, Kitamura K-I, Sekiguchi T, Chowdhury VS, Funahashi H, Omori K, Endo M, Yano S, Yamada S, Hayakawa K, Chiba A, Srivastav AK, Ijiri K, Hattori1 A, Suzuki N

      Biological Sciences in Space,26   26 - 31   12 2012

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    • プロスタグランジンE2はキンギョにおいて鱗の骨芽細胞活性化と破骨細胞活性化を増強させ、カルシウム代謝に関与する(Prostagiandln E2 Increases Both Osteoblastic and Osteoclastic Activity in the Scales and Participates in Calcium Metabolism in Goldfish)

      Omori Katsunori, Wada Shigehito, Maruyama Yusuke, Hattori Atsuhiko, Kitamura Kei-ichiro, Sato Yusuke, Nara Masayuki, Funahashi Hisayuki, Yachiguchi Koji, Hayakawa Kazuichi, Endo Masato, Kusakari Rei, Yano Sachiko, Srivastav Ajai K, Kusui Takashi, Ejiri Sadakazu, Chen Wenxi, Tabuchi Yoshiaki, Furusawa Yukihiro, Kondo Takashi, Sasayama Yuichi, Nishiuchi Takumi, Nakano Masaki, Sakamoto Tatsuya, Suzuki Nobuo

      Zoological Science29 ( 8 ) 499 - 504   8 2012

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      Language：English   Publisher：(公社)日本動物学会  

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    • Expression of osteoblastic and osteoclastic genes during spontaneous regeneration and autotransplantation of goldfish scale: A new tool to study intramembranous bone regeneration Peer-reviewed

      Thiparpa Aime Thamamongood, Ryo Furuya, Shunsuke Fukuba, Masahisa Nakamura, Nobuo Suzuki, Atsuhiko Hattori

      BONE50 ( 6 ) 1240 - 1249   6 2012

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.bone.2012.03.021

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    • The connection between the periodicity of incremental lines in the tooth dentin and the regulation by melatonin Peer-reviewed

      Mishima H, Hattori A, Suzuki N, Tabata M. J, Kakei M, Miake Y, Suzuki M

      BONE50   S102 - S102   5 2012

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      DOI： 10.1016/j.bone.2012.02.309

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    • Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: Possible physiological roles of the calcitonin family in osmoregulation Peer-reviewed

      Nobuo Suzuki, Toshio Sekiguchi, Honoo Satake, Kanoko Kato, Yudai Nishiyama, Hideya Takahashi, Janine A. Danks, T. John Martin, Atsuhiko Hattori, Masaki Nakano, Makiko Kakikawa, Sotoshi Yamada, Maho Ogoshi, Susumu Hyodo, Yoko Yamaguchi, Vishwajit S. Chowdhury, Kazuichi Hayakawa, Hisayuki Funahashi, Tatsuya Sakamoto, Yuichi Sasayama

      GENE499 ( 2 ) 326 - 331   5 2012

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.gene.2012.03.042

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    • Parathyroid hormone 1 (1-34) acts on the scales and involves calcium metabolism in goldfish Peer-reviewed

      Nobuo Suzuki, Janine A. Danks, Yusuke Maruyama, Mika Ikegame, Yuichi Sasayama, Atsuhiko Hattori, Masahisa Nakamura, Makoto J. Tabata, Toshio Yamamoto, Ryo Furuya, Kiyofumi Saijoh, Hiroyuki Mishima, Ajai K. Srivastav, Yukihiro Furusawa, Takashi Kondo, Yoshiaki Tabuchi, Ichiro Takasaki, Vishwajit S. Chowdhury, Kazuichi Hayakawa, T. John Martin

      BONE48 ( 5 ) 1186 - 1193   5 2011

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.bone.2011.02.004

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    • Effects of Inorganic Mmercury on Osteoclasts and Osteoblasts of the Goldfish Scales In Vitro Peer-reviewed

      Nobuo Suzuki, Koji Yachiguchi, Kazuichi Hayakawa, Katsunori Omori, Koji Takada, Makoto J. Tabata, Kei-Ichiro Kitamura, Masato Endo, Shigehito Wada, Ajai K. Srivastav, Vishwajit S. Chowdhury, Yuji Oshima, Atsuhiko Hattori

      JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY56 ( 1 ) 47 - 51   2 2011

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    • Synchronised expressions of LPXRFamide peptide and its receptor genes: seasonal, diurnal and circadian changes during spawning period in grass puffer.

      Shahjahan M, Ikegami T, Osugi T, Ukena K, Doi H, Hattori A, Tsutsui K, Ando H

      J Neuroendocrinol23 ( 1 ) 39 - 51   1 2011

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1111/j.1365-2826.2010.02081.x

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    • Osteoblast activity in the goldfish scale responds sensitively to mechanical stress Peer-reviewed

      Kei-ichiro Kitamura, Nobuo Suzuki, Yusuke Sato, Tetsu Nemoto, Mika Ikegame, Nobuaki Shimizu, Takashi Kondo, Yukihiro Furusawa, Shigehito Wada, Atsuhiko Hattori

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY156 ( 3 ) 357 - 363   7 2010

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.cbpa.2010.03.002

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    • Melatonin Stimulates the Release of Gonadotropin-Inhibitory Hormone by the Avian Hypothalamus

      Chowdhury, Vishwajit S, Yamamoto, Kazutoshi, Ubuka, Takayoshi, Bentley, George E, Hattori, Atsuhiko, Tsutsui, Kazuyoshi

      ENDOCRINOLOGY151 ( 1 ) 271 - 280   2010

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    • Synchronized diurnal and circadian expressions of four subtypes of melatonin receptor genes in the diencephalon of a puffer fish with lunar-related spawning cycles.

      Ikegami T, Motohashi E, Doi H, Hattori A, Ando H

      Neurosci Lett462 ( 1 ) 58 - 63   10 2009

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.neulet.2009.06.076

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    • Effect of low-intensity pulsed ultrasound on osteoblasts and osteoclasts of the zebrafish scales Peer-reviewed

      Suzuki N, Furusawa Y, Takasaki I, Tabuchi Y, Kitamura K, Wada S, Hori T, Kondo T, Nemoto T, Shimizu N, Hattori A

      BONE44   S157 - S157   5 2009

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      DOI： 10.1016/j.bone.2009.01.347

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    • Monohydroxylated polycyclic aromatic hydrocarbons inhibit both osteoclastic and osteoblastic activities in teleost scales Peer-reviewed

      Nobuo Suzuki, Kazuichi Hayakawa, Takayuki Kameda, Akira Triba, Ning Tang, Makoto J. Tabata, Koji Takada, Shigehito Wada, Katsunori Omori, Ajai K. Srivastav, Hiroyuki Mishima, Atsuhiko Hattori

      LIFE SCIENCES84 ( 13-14 ) 482 - 488   3 2009

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.lfs.2009.01.008

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    • Diurnal expressions of four subtypes of melatonin receptor genes in the optic tectum and retina of goldfish

      Taro Ikegami, Kyoichi Azuma, Masahisa Nakamura, Nobuo Suzuki, Atsuhiko Hattori, Hironori Ando

      Comparative Biochemistry and Physiology152   219 - 224   2009

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      DOI： 10.1016/j.cbpa.2008.09.030

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    • Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration.

      Oba S, Nakamura K, Sahashi Y, Hattori A, Nagata C

      J Pineal Res45 ( 1 ) 17 - 23   8 2008

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1111/j.1600-079X.2007.00549.x

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    • Novel bromomelatonin derivatives suppress osteoclastic activity and increase osteoblastic activity: implications for the treatment of bone diseases Peer-reviewed

      Nobuo Suzuki, Masanori Somei, Kei-Ichiro Kitamura, Russel J. Reiter, Atsuhiko Hattori

      JOURNAL OF PINEAL RESEARCH44 ( 3 ) 326 - 334   4 2008

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1111/j.1600-079X.2007.00533.x

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    • Scale osteoblasts and osteoclasts sensitively respond to low-gravity loading by centrifuge.

      Biological Sciences in Space22 ( 1 ) 3 - 7   2008

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    • Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts. Peer-reviewed

      TAKAHASHI Hideya, SUZUKI Nobuo, TAKAGI Chiyo, IKEGAME Mika, YAMAMOTO Toshio, TAKAHASHI Akiyoshi, MORIYAMA Shunsuke, HATTORI Atsuhiko, SAKAMOTO Tatsuya

      ZOOLOGICAL SCIENCE25 ( 7 ) 739 - 745   2008

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    • Diurnal change of thyroid-stimulating hormone mRNA expression in the rat pars tuberalis Peer-reviewed

      Aizawa S, Hoshino S, Sakata I, Adachi A, Yashima S, Hattori A, Sakai T

      JOURNAL OF NEUROENDOCRINOLOGY19 ( 11 ) 839 - 846   11 2007

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      Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

      DOI： 10.1111/j.1365-2826.2007.01603.x

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    • Two osteoclastic markers expressed in multinucleate osteoclasts of goldfish scales Peer-reviewed

      KyoIchi Azuma, Masaki Kobayashi, Masahisa Nakamura, Nobuo Suzuki, Sayaka Yashima, Shawichi Iwamuro, Mika Ikegame, Toshio Yamamoto, Atsuhiko Hattori

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS362 ( 3 ) 594 - 600   10 2007

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1016/j.bbrc.2007.08.010

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    • 新規1-ヒドロキシインドール誘導体の抗菌作用

      鈴木 信雄, 服部 淳彦, 唐原 一郎, 神阪 盛一郎, 染井 正徳

      日本薬学会年会要旨集127年会 ( 4 ) 128 - 128   3 2007

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    • S3-8 Effects of low-intensity ultrasound on bone metabolism in goldfish scale(Symposium (3) Biomedical Application)

      Kitamura Kei-ichiro, Suzuki Nobuo, Nemoto Tetsu, Shimizu Nobuaki, Tabata Makoto J., Wada Shigehito, Omori Katsunori, Nakamura Masahisa, Kondo Takashi, Hattori Atsuhiko

      Proceedings of the Annual Meeting of the Japan Society of Sonochemistry2007   54 - 54   2007

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      Language：English   Publisher：The Japan Society of Sonochemistry  

      DOI： 10.20577/pamjss.2007.suppl.0_54

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    • Effect of vibration on osteoblastic and osteoclastic activities: Analysis of bone metabolism using goldfish scale as a model for bone Peer-reviewed

      Suzuki N, Kitamura K, Nemoto T, Shimizu N, Wada S, Kondo T, Tabata M. J, Sodeyama F, Ijiri K, Hattori A

      ADVANCES IN SPACE RESEARCH40 ( 11 ) 1711 - 1721   2007

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    • The chemistry of indoles - part 128 - The ideal synthetic method aimed at the leads for an alpha(2)-blocker, an inhibitor of blood platelet aggregation, and an anti-osteoporosis agent Peer-reviewed

      Masanori Somei, Takako Iwaki, Fumio Yamada, Yoshio Tanaka, Koki Shigenobu, Katsuo Koike, Nobuo Suzuki, Atsuhiko Hattori

      HETEROCYCLES68 ( 8 ) 1565 - 1569   8 2006

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    • 線維芽細胞成長因子－２の骨芽細胞活性化作用に対する表皮ブドウ球菌膜蛋白質による抑制

      倉持 大輔, 松下 和彦, 加藤 晴康, 河野 照茂, 五十嵐 潤子[右高], 平田 和明, 鈴木 信雄, 服部 淳彦, 別府 諸兄

      聖マリアンナ医科大学雑誌34 ( 4 ) 395 - 404   2006

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    • A2 Promotive action of bone formation by ultrasound stimulation : analysis of osteoblasts and osteoclasts using a fish scale in vitro assay system

      Suzuki Nobuo, Kitamura Kei-ichiro, Nemoto Tetsu, Shimizu Nobuaki, Wada Shigehito, Kondo Takashi, Ijiri Kenichi, Tabata Makoto J., Niimi Nobuo, Hattori Atsuhiko

      Proceedings of the Annual Meeting of the Japan Society of Sonochemistry15   3 - 4   2006

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      Language：Japanese   Publisher：The Japan Society of Sonochemistry  

      We recently developed a new in vitro assay system for the evaluation of bone metabolism using goldfish scale. This system can simultaneously detect the activities of both scale osteoblasts (formation cells) and osteoclasts (resorption cells) with alkaline phosphatase and tartrate-resistant acid phosphatase as markers. Using this scale in vitro assay system, in the present study, we analyzed the effect of ultrasound (US) stimulation on osteoblastic and osteoclastic activities. The osteoblastic activity significantly increased by pulsed low-density US (1MHz, 60mW/cm^2 I_<SATA>, 50% duty factor at 0.5Hz, 180 pulses) in 18 hrs of incubation at 15℃ after US treatment but not in shorter incubation periods, while the osteoclastic activity did not change in the same incubation period. To examine the mechanism of US in osteoblasts, the estrogen receptor (ER) and insulin-like growth factor-I (IGF-I) mRNA expressions in the cultured scales were analyzed by RT-PCR. ER mRNA expression was found to be higher in the US-treated scales than in the control scales in 18 hrs of incubation at 15℃ after treatment, although ER mRNA expression did not change in 3 hrs of incubation. On the other hand, IGF-I mRNA expression increased in 3 hrs of incubation at 15℃ after US treatment. Therefore, IGF-I mRNA expression was more rapid to respond to US than ER mRNA expression, and IGF-I may have an important function in the activation of osteoblasts by US treatment. We found that both osteoblastic and osteoclastic activities increased in the remaining ontogenic scales of the left side at 3 days after the removal of all scales in the right side. Using these scales, we examined the effects of US stimulation on osteoblasts and osteoclasts under the same conditions described above. In 18 hrs of incubation at 15℃ after US treatment, the osteoblastic activity increased by US treatment in the ontogenic scale as well as the normal scale. Furthermore, we indicated that the osteoclastic activity in the ontogenic scale decreased by US treatment. The conditions of osteoblasts and osteoclasts in the ontogenic scale are similar to those in the human osteoporosis, indicating that US stimulation may contribute to the cure of osteoporosis.

      DOI： 10.20577/pamjss.15.0_3

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    • Tributyltin inhibits osteoblastic activity and disrupts calcium metabolism through an increase in plasma calcium and calcitonin levels in teleosts. Peer-reviewed

      SUZUKI Nobuo, TABATA Makoto J, KAMBEGAWA Akira, SRIVASTAV Ajai K, SHIMADA Atsuko, TAKEDA Hiroyuki, KOBAYASHI Masaki, WADA Shigehito, KATSUMATA Toshiyuki, HATTORI Atsuhiko

      LIFE SCIENCES78 ( 21 ) 2533 - 2541   2006

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    • Do goldfish scleroblasts correspond mammalian cells in bone? Peer-reviewed

      Saijoh K, Suzuki N, Katsuyama H, Li LH, Higashi T, Tanii H, Tamada-Nishimura F, Hattori A

      FASEB JOURNAL19 ( 4 ) A58 - A58   3 2005

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    • The effect of melatonin in the IL-8 production and cell damage in vitro (using human normal gastric nucosal cell which has been cultured for more than one year). Peer-reviewed

      Kojima T, Satoh K, Kawakami S, Kimura K, Hattori A

      GASTROENTEROLOGY114 ( 4 ) A1155 - A1155   4 1998

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    • Hydroxyindole-O-methyltransferase activity assay using high-performance liquid chromatography with fluorometric detection: Determination of melatonin enzymatically formed from N-acetylserotonin and S-adenosyl-L-methionine Peer-reviewed

      Itoh MT, Hattori A, Sumi Y

      JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES692 ( 1 ) 217 - 221   4 1997

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    • Regulation by guanine nucleotides and cations of melatonin binding sites in the goldfish brain Peer-reviewed

      Masayuki Iigo, Ritsuko Ohtani-Kaneko, Masayuki Hara, Atsuhiko Hattori, Hidehito Takahashi, Mitsuo Tabata, Takuro Suzuki, Katsumi Aida

      NeuroSignals6 ( 1 ) 29 - 39   1997

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      Language：English   Publishing type：Research paper (scientific journal)  

      DOI： 10.1159/000109106

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    • Characterization, Guanosine 5'-O-(3-thiotriphosphate) modulation, daily variation, and localization of melatonin-binding sites in the catfish (Silurus a sotus) Brain (共著) Peer-reviewed

      Iigo M, Hattori A, Ohtani-Kaneko R, Aida K

      General and Comparative Endocrinology108   45 - 55   1997

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    Misc.

    • ヒト関節軟骨細胞における周期的遺伝子発現に対するメラトニンの影響(Effect of melatonin on rhythmic gene expression in human articular chondrocytes)

      Fu Shanqi, 桑原 実穂, 内田 瑶子, 林 大智, 下村 侑司, 高垣 安紗美, 西田 崇, 中田 英二, 古松 毅之, 近藤 星, 丸山 雄介, 服部 淳彦, 久保田 聡, 服部 高子

      日本生化学会大会プログラム・講演要旨集93回   [2Z12 - 484)]   9 2020

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      Language：English   Publisher：(公社)日本生化学会  

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    • Melatonin and glucose metabolism Peer-reviewed

      Kazuki Watanabe, Sayaka Katagiri, Atsuhiko Hattori

      Glycative Stress Research7 ( 1 ) 105 - 109   4 2020

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      Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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    • 骨粗鬆症モデルラットにおける副甲状腺ホルモンとメラトニンの併用効果

      池亀 美華, 田中 みか子, 江尻 貞一, 服部 淳彦, 高尾 亮子, 内部 健太, 岡村 裕彦

      Journal of Oral Biosciences Supplement2018   206 - 206   9 2018

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      Language：Japanese   Publisher：(一社)歯科基礎医学会  

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    • 軟骨におけるメラトニンとその受容体の日周的合成は軟骨の律動的遺伝子発現に影響を及ぼす(Circadian production of melatonin and its receptors in cartilage influences chondrocyte rhythmic gene expression)

      Fu Shanqi, 桑原 実穂, 内田 瑶子, 林 大智, 下村 侑司, 高垣 安紗美, 西田 崇, 丸山 雄介, 池亀 美華, 服部 淳彦, 服部 高子, 久保田 聡

      日本生化学会大会プログラム・講演要旨集91回   [1T14m - 07(1P   9 2018

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    • メラトニン－睡眠とアンチエイジング Invited

      服部淳彦

      全薬Journal ( 284 ) 10 - 13   4 2018

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      Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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    • Toxicities of polycyclic aromatic hydrocarbons in fish and marine invertebrates.

      Suzuki, N, Ikari, T, Sato, M, Toriba, A, Sekiguchi, T, Kitani, Y, Ogiso, S, Yachiguchi, K, Hattori, A, Oshima, Y, Hayakawa, K

      Polycyclic Aromatic Hydrocarbons: Environmental Behavior and Toxicity in East Asia   245 - 259   1 2018

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      Language：English   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：Springer  

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    • 軟骨組織におけるメラトニン合成とその受容体発現は概日リズムを持ち、軟骨細胞の代謝に影響を及ぼす

      服部 高子, Fu Shanqi, 桑原 実穂, 内田 瑶子, 近藤 星, 林 大智, 下村 侑司, 高垣 安紗美, 西田 崇, 丸山 雄介, 池亀 美華, 服部 淳彦, 久保田 聡

      生命科学系学会合同年次大会2017年度   [2P - 1190]   12 2017

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      J-GLOBAL

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    • キンギョ鱗の骨組織研究への応用 Invited Peer-reviewed

      池亀美香, 服部淳彦, 鈴木信雄

      The Bone31 ( 2 ) 3 - 8   8 2017

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    • 概日リズム同調因子メラトニンによる象牙質や象牙芽細胞の組織構造への影響

      三島弘幸, 田辺咲貴, 服部淳彦, 鈴木信雄, 筧光男, 松本敬, 池亀美華, 見明康雄, 松本由樹

      化石研究会会誌50 ( 2 )   2017

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    • Melatonin and Aging Invited Peer-reviewed

      Atsuhiko Hattori

        34 ( 1 ) 2 - 11   1 2017

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      Other Link： http://search.jamas.or.jp/link/ui/2017246704

    • Fish scale is a suitable model for analyzing determinants of skeletal fragility in type 2 diabetes

      Nobuo Suzuki, Kei-ichiro Kitamura, Atsuhiko Hattori

      ENDOCRINE54 ( 3 ) 575 - 577   12 2016

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      DOI： 10.1007/s12020-016-1153-9

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    • 9. Effects of Low-Intensity Pulsed Ultrasound (LIPUS) on Osteoclasts and Osteoblasts: Analysis Using an Assay System With Fish Scale as a Model of Bone. International journal

      Nobuo Suzuki, Taizo Hanmoto, Mika Ikegame, Yukihiro Furusawa, Yoshiaki Tabuchi, Takashi Kondo, Kei-Ichiro Kitamura, Toshio Sekiguchi, Yuko Mikuni-Takagaki, Atsuhiko Hattori

      Journal of orthopaedic trauma30 ( 8 ) S4-S4 - S4   2016

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      OBJECTIVE: Low-intensity pulsed ultrasound (LIPUS) provides noninvasive therapeutic treatment to accelerate fracture repair and distraction osteogenesis. However, most studies concerning the influence of LIPUS on bone metabolism have been conducted in vivo systems using osteoblastic cells. Therefore, details of the direct effect of LIPUS on osteoclasts are not yet fully understood. Teleost scale is a calcified tissue that contains osteoclasts and osteoblasts. Its bone matrix consists of type I collagen and hydroxyapatite, and is similar to that of mammalian bone. Therefore, we examined the effect of LIPUS on the osteoclasts and osteoblasts of zebrafish and goldfish scales, as a model of the bone matrix simplified to its bare bones. METHODS: Ultrasound was generated with the Sonic Accelerated Fracture Healing System (SAFHS 4000J; Teijin Pharma, Ltd). Scales were collected from zebrafish under anesthesia; they were then treated with LIPUS for 20 minutes, incubated at 15°C for 3, 6, and 18 hours in L-15 medium, and subjected to measurement of the mRNA expression. Following the osteoclast induction by the autotransplantation of goldfish scales, we further examined the number of apoptotic osteoclasts after LIPUS treatment. RESULTS AND DISCUSSION: At 3 hours of incubation after LIPUS treatment, osteoclastic marker expression decreased while osteoblastic markers increased. Using GeneChip analysis of zebrafish scales treated by LIPUS, we found that cell death-related genes were up-regulated by LIPUS treatment. TUNEL staining showed that the number of apoptotic osteoclasts in goldfish scales was elevated by treatment with LIPUS at 3 hours of incubation. Thus, we conclude that LIPUS promotes apoptosis in osteoclasts shortly after exposure.

      DOI： 10.1097/01.bot.0000489982.40329.52

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    • The Influence that Melatonin Gives in Dentin Histology, the Odontoblasts and the Period of Incremental Lines of Dentin

      三島弘幸, 尾崎真帆, 武内昇平, 武市和彦, 服部淳彦, 鈴木信雄, 筧光夫, 松本敬, 池亀美華, 池亀美華, 見明康雄

      日本再生歯科医学会誌13 ( 1 )   2015

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    • Effect of Melatonin on Bone Metabolism and its Application for the Treatment of Bone Disease

      Anti-aging medicine10 ( 5 ) 697 - 702   10 2014

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    • Melatonin, space flight and osteoporosis

        38 ( 2 ) 190 - 200   2 2014

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    • メラトニン投与における象牙質の成長線の形成や象牙質組成に関する分析学的及び組織学的研究

      三島弘幸, 門田理佳, 服部淳彦, 鈴木信雄, 筧光夫, 松本敬, 里村一人, 見明康雄

      日本解剖学会総会・全国学術集会講演プログラム・抄録集119th   2014

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    • メラトニン投与による象牙質の組成や組織構造の変化に関する分析学的及び組織学的研究

      三島弘幸, 門田理佳, 尾碕真帆, 服部淳彦, 鈴木信雄, 筧光男, 松本敬, 池亀美華, 見明康雄

      日本再生歯科医学会誌12 ( 1 ) 11 - 22   2014

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      DOI： 10.11223/jard.12.11

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    • 象牙質の成長線形成機構と体内時計の情報伝達分子であるメラトニンの分泌リズムの関係

      三島弘幸, 井上昌子, 服部淳彦, 鈴木信雄, 田畑純, 筧光夫, 松本敬, 里村一人, 見明康雄

      日本解剖学会総会・全国学術集会講演プログラム・抄録集118th   2013

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    • 象牙質の成長線形成と体内時計の情報伝達分子メラトニンの関連

      三島弘幸, 門田理佳, 井上昌子, 服部淳彦, 鈴木信雄, 田畑純, 筧光夫, 松本敬, 里村一人, 見明康雄

      化石研究会会誌46 ( 1 )   2013

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    • キンギョを用いた糖尿病様モデルのインスリン産生能の解析

      北村敬一郎, 安藤忠, 桶作若菜, 遠藤雅人, 服部淳彦, 鈴木信雄

      日本神経内分泌学会学術集会プログラム・抄録集40th   2013

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    • キンギョウロコのアパタイトの解析-赤外ラマン分光によるアプローチ

      奈良雅之, 服部淳彦, 大西晃宏, 赤塚陽子, 矢野幸子, 鈴木信雄, 松田准一

      バイオイメージング22 ( 2 )   2013

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    • Development of an Assay System Using Fish Scales and Its Application to the Study of Bone Metabolism

      SUZUKI N., FUNAHASHI H., KOU K., KAKIKAWA M., YAMADA S., HIROTA N., KITAMURA K., SHIMIZU N., HAYAKAWA K., MISHIMA H., IWASAKA M., UENO S., OMORI K., YANO S., IKEGAME M., TABUCHI Y., WADA S., KONDO T., HATTORI A.

        7 ( 4 ) 174 - 178   1 8 2012

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    • メラトニンの新規作用：骨に対する作用とその誘導体を用いた骨疾患治療薬の開発

      鈴木 信雄, 関 あずさ, 染井 正徳, 中村 正久, 矢野 幸子, 大森 克徳, 池亀 美華, 三島 弘幸, 早川 和一, 服部 淳彦

      比較内分泌学37 ( 143 ) 194 - 203   2011

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      Language：Japanese   Publisher：Japan Society for Comparative Endocrinology  

      DOI： 10.5983/nl2008jsce.37.194

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    • 歯の象牙質における成長線の周期性と生物リズムとの関連 : メラトニンによる調節の可能性

      三島 弘幸, 北原 正大, 服部 淳彦, 鈴木 信雄, 田畑 純, 奈良 雅之, 筧 光男, 見明 康夫

      比較内分泌学 = Comparative endocrinology36 ( 137 ) 106 - 112   31 5 2010

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      Language：Japanese   Publisher：日本比較内分泌学会  

      DOI： 10.5983/nl2008jsce.36.106

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      Other Link： http://search.jamas.or.jp/link/ui/2010234144

    • Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases

      Nobuo Suzuki, Masanori Somei, Azusa Seki, Russel J. Reiter, Atsuhiko Hattori

      JOURNAL OF PINEAL RESEARCH45 ( 3 ) 229 - 234   10 2008

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      DOI： 10.1111/j.1600-079X.2008.00623.x

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    • Response of osteoblasts and osteoclasts to acceleration loading by vibration

        2007   109 - 110   31 7 2008

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    • Effects of novel bromomelatonin derivatives on osteoclasts and osteoblasts

        2007   111 - 112   31 7 2008

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    • ANALYSIS OF OSTEOBLAST SPECIFIC MESSENGER RNA EXPRESSION IN THE REGENERATING SCALE OF GOLDFISH, Carassius auratus

      FURUYA Ryo, KOBAYASHI Masaki, NAKAMURA Masahisa, SUZUKI Nobuo, HATTORI Atsuhiko

        ( 22 ) 50 - 50   12 10 2007

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    • ESTABLISHMENT OF EXPERIMENTAL MODEL FOR BONE DISEASE USING THE SCALE OF GOLDFISH, Carassius auratus

      THAMAMONGOOD Thiparpa, TABATA Jun, NAKAMURA Masahisa, SUZUKI Nobuo, HATTORI Atsuhiko

        ( 22 ) 51 - 51   12 10 2007

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    • Novel bromomelatonin derivatives activate osteoblasts and suppress osteoclasts in the goldfish scale

      N. Suzuki, M. Somei, K. Kitamura, A. Hattori

      BONE40 ( 6 ) S177 - S178   6 2007

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    • 魚鱗:硬組織研究と再生研究のフロンティア (特集 硬組織の進化)

      田畑 純, 鈴木 信雄, 服部 淳彦

      細胞39 ( 2 ) 55 - 57   2 2007

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      Other Link： http://search.jamas.or.jp/link/ui/2007135425

    • 歯の成長線の周期性にメラトニンが関与する可能性

      三島弘幸, 鈴木信雄, 田畑純, 大野由香, 中石裕子, 野村加代, 服部淳彦

      解剖学雑誌82 ( 3 )   2007

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    • Effect of FGF-2 on osteoblasts and osteoclasts in regenerating scales of the goldfish

      Daisuke Kuramochi, Haruyasu Kato, Moroe Beppu, Junko Migitaka, Kazuaki Hirata, Nobuo Suzuki, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE23 ( 12 ) 1210 - 1210   12 2006

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    • Effect of melatonin on the differentiation of osteoclasts in the goldfish scale

      Kyouichi Azuma, Ryo Sugiura, Nobuo Suzuki, Masahisa Nakamura, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE23 ( 12 ) 1210 - 1210   12 2006

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    • Molecular cloning and gene expression of the key enzymes of melatonin synthesis in the goldfish scale

      Shinnosuke Miki, Sayaka Yashima, Nobuo Suzuki, Masahisa Nakamura, Atsuhiko Hattori, Shawichi Iwamuro

      ZOOLOGICAL SCIENCE23 ( 12 ) 1209 - 1209   12 2006

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    • Bromomelatonin derivatives suppressed osteoclastic activity but increased osteoblastic activity

      Nobuo Suzuki, Masanori Somei, Kei-Ichirou Kitarnura, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE23 ( 12 ) 1209 - 1209   12 2006

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    • Analysis of syndecans in regenerating and allotransplanted scales of the goldfish

      Toshiyuki Katsumata, Mitsuyo Okazaki, Nobuo Suzuki, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE23 ( 12 ) 1210 - 1210   12 2006

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    • メラトニン Up to Date--骨とメラトニン

      服部 淳彦, 鈴木 信雄, 染井 正徳

      アンチ・エイジング医学2 ( 1 ) 78 - 86   2 2006

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      Other Link： http://search.jamas.or.jp/link/ui/2006140136

    • Molecular cloning of cDNAs encoding markers in osteoclasts, trap and cathepsin K in goldfish

      Masaki Kobayashi, Kyouichi Azuma, Nobuo Suzuki, Atsuhiko Hattori, Masahisa Nakamura

      ZOOLOGICAL SCIENCE22 ( 12 ) 1499 - 1499   12 2005

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    • Prolactin inhibits osteoclastic activities in the scales of goldfish

      Nobuo Suzuki, Tatsuya Sakamoto, Mika Ikegame, Toshio Yamamoto, Akiyoshi Takahashi, Shunsuke Moriyama, Hiroshi Kawauchi, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE22 ( 12 ) 1498 - 1498   12 2005

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    • cDNA cloning of specific genes involved in the differentiation of osteoclasts in allotransplanted scales of the goldfish

      Akihiro Nishimura, Sakae Kikuyama, Nobuo Suzuki, Masayuki Hara, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE22 ( 12 ) 1499 - 1499   12 2005

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    • Expression analysis of Timp-2 during osteoclast activation in the scales of goldfish

      Kyouichi Azuma, Atsuhiko Hattori, Nobuo Suzuki, Masahisa Nakamura

      ZOOLOGICAL SCIENCE22 ( 12 ) 1499 - 1499   12 2005

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    • Changes of melatonin concentrations in the scale of female goldfish during reproductive period

      Sayaka Yashima, Shawichi Iwamuro, Nobuo Suzuki, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE22 ( 12 ) 1498 - 1499   12 2005

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    • EFFECTS OF MELATONIN ON OSTEOCLAST DIFFERENTIATION INDUCED BY AN INTRAMUSCULAR AUTOTRANSPLANTATION OF THE GOLDFISH SCALE

      SUGIURA Ryo, AZUMA Kyoichi, KOBAYASHI Masaki, NAKAMURA Masahisa, SUZUKI Nobuo, HATTORI Atsuhiko

        ( 20 ) 30 - 30   12 11 2005

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    • POSSIBLE FUNCTION OF MELATONIN ON CALCIUM METABOLISM IN THE SCALE OF FEMALE GOLDFISH IN THE REPRODUCTIVE STAGE

      YASHIMA Sayaka, IWAMURO Shawichi, SUZUKI Nobuo, HATTORI Atsuhiko

        ( 20 ) 31 - 31   12 11 2005

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    • ANALYSIS OF HEPARAN SULFATE PROTEOGLYCANS IN THE SCALE OF GOLDFISH

      KATSUMATA Toshiyuki, OKAZAKI Mitsuyo, SUZUKI Nobuo, HATTORI Atsuhiko

        ( 20 ) 29 - 29   12 11 2005

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    • Physiological role of melatonin in the scale of teleost

      N Suzuki, S Yashima, S Iwamuro, A Hattori

      BONE36   S302 - S302   6 2005

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    • Osteoblastic activity and estrogenic response in the regenerating scale of goldfish, a good model of osteogenesis

      H Yoshikubo, N Suzuki, K Takemura, M Hoso, S Yashima, S Iwamuro, Y Takagi, MJ Tabata, A Hattori

      LIFE SCIENCES76 ( 23 ) 2699 - 2709   4 2005

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      DOI： 10.1016/j.lfs.2004.10.063

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    • Daily and circadian variations of the pineal and ocular melatonin contents and their contributions to the circulating melatonin in the Japanese newt, Cynops pyrrhogaster

      A Chiba, A Hattori, M Iigo

      ZOOLOGICAL SCIENCE22 ( 1 ) 65 - 70   1 2005

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      DOI： 10.2108/zsj.22.65

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    • Changes in Ossificational Process of the Vertebral Body in Pinealectomized Chickens

      TORII Yoshiaki

        19 ( 1 ) 78 - 82   20 12 2004

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    • Effects of melatonin on osteoclasts in the scale induced by intramuscular autotransplantation in goldfish

      Ryo Sugiura, Tetuya Kobayasi, Takeo Matida, Nobuo Suzuki, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE21 ( 12 ) 1339 - 1339   12 2004

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    • Mechanism of osteogenesis in teleosts: Analysis by regenerating scale of goldfish

      Nobuo Suzuki, Hiroaki Yoshikubo, Keiju Takemura, Masahiro Hoso, Sayaka Yashima, Shawichi Iwamuro, Yasuaki Takai, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE21 ( 12 ) 1339 - 1339   12 2004

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    • Seasonal changes in the concentrations of melatonin and 5-methoxytryptophol in the scales of male and female goldfish

      Sayaka Yashimia, Shawichi Iwamuro, Nobuo Suzuki, Atsuhiko Hattori

      ZOOLOGICAL SCIENCE21 ( 12 ) 1339 - 1339   12 2004

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    • Presence of melatonin and expression of N-acetyltransferase mRNA in the scales of goldfish

      Atsuhiko Hattori, Sayaka Yashima, Shawichi Iwamuro, Nobuo Suzuki

      ZOOLOGICAL SCIENCE21 ( 12 ) 1339 - 1339   12 2004

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    • Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism

      N Suzuki, M Yamamoto, K Watanabe, A Kambegawa, A Hattori

      JOURNAL OF BONE AND MINERAL METABOLISM22 ( 5 ) 439 - 446   9 2004

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      DOI： 10.1007/s00774-004-0505-3

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    • メラトニン分泌を促す生活療法

      服部淳彦

      Geriat. Med.42, 1121-1126   1121 - 1126   2004

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    • Bisphenol A suppresses osteoclastic and osteoblastic activities in the cultured scales of goldfish

      N Suzuki, A Hattori

      LIFE SCIENCES73 ( 17 ) 2237 - 2247   9 2003

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    • Bisphenol A influences the plasma calcium level and inhibits calcitonin secretion in goldfish

      N Suzuki, A Kambegawa, A Hattori

      ZOOLOGICAL SCIENCE20 ( 6 ) 745 - 748   6 2003

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      DOI： 10.2108/zsj.20.745

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    • EFFECTS OF BISPHENOL-A AND CADMIUM ON OSTEOCLASTS AND OSTEOBLASTS IN THE SCALES OF GOLDFISH(Endocrinology,Abstracts of papers presented at the 74^<th> Annual Meeting of the Zoological Society of Japan) :

      Suzuki Nobuo, Hattori Atsuhiko

      Zoological science20 ( 12 ) 1600 - 1601   2003

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      Other Link： http://id.nii.ac.jp/1141/00038257/

    • Melatonin suppresses osteoclastic and osteoblastic activities in the scales of goldfish

      N Suzuki, A Hattori

      JOURNAL OF PINEAL RESEARCH33 ( 4 ) 253 - 258   11 2002

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    • EFFECTS OF MELATONIN ON OSTEOCLAST AND OSTEOBLAST CELLS IN THE SCALE OF GOLDFISH(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan) :

      Suzuki Nobuo, Hattori Atsuhiko

      Zoological science19 ( 12 ) 1485 - 1485   2002

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      Other Link： http://id.nii.ac.jp/1141/00037298/

    • EFFECTS OF MELATONIN ON OSTEOCLASTIC AND OSTEOBLASTIC ACTIVITIES IN CULTURED FRONTAL BONES OF CHICKS(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan) :

      Sano Akimi, Tsubaki Tomohiro, Hanazono Makoto, Suzuki Nobuo, Hattori Atsuhiko

      Zoological science19 ( 12 ) 1485 - 1485   2002

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      Other Link： http://id.nii.ac.jp/1141/00037299/

    • 松果体除去ニワトリにおける実験的側湾症とＩＧＦ-1について

      脊柱変形17巻1-4   2002

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    • メラトニンと睡眠

      Annual Review 神経20027-17   2002

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    • EFFECTS OF ESTRADIOL ON DIFFERENTIATION OF REPRODUCTIVE ORGANS AND DEVELOPMENT OF THE SPINE IN CHICK EMBRYOS

      TSUBAKI Tomohiro, HATTORI Atsuhiko, NAKAYAMA Hitoshi, OKAZAKI Mitsuyo, WADA Masaru, IWAMURO Showichi, HANAZONO Makoto

        16   30 - 30   1 12 2001

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    • Changes in melatonin concentrations during IFN therapy

      Y Uchimura, N Uchimura, R Kumashiro, A Hattori, M Sata

      JOURNAL OF HEPATOLOGY31 ( 6 ) 1131 - 1131   12 1999

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      Language：English   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)  

      DOI： 10.1016/S0168-8278(99)80329-8

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    • PLASMA CALCITONIN AND CA LEVELS IN CHICKS SUFFERED FROM BENDING OF VERTEBRAE BY PINEALECTOMY

      SUZUKI Daisuke, HATTORI Atsuhiko, KOMURO Sanae, SUZUKI Nobuo, SASAYAMA Yuichi, KAMBEGAWA Akira, ASAHINA Kiyosi

        13   62 - 62   7 1998

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    • Effects of a low-protein diet on prolactin- and growth hormone-producing cells in the rat pituitary gland

      M Hara, DC Herbert, T Taniguchi, A Hattori, R Ohtani-Kaneko, M Iigo, Y Kato, K Hirata

      ANATOMICAL RECORD251 ( 1 ) 37 - 43   5 1998

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    • 実験的側湾症におけるＩＧＦ-1発現の免疫組織学的検討

      聖マリアンナ医大誌26巻417-423   1998

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    • メラトニンのIL-8分泌に及ぼす影響

      実験潰瘍25   248 - 250   1998

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    • ONTOGENESIS OF PROLACTIN GENE EXPRESSION IN RAT FETAL PITUITARY GLAND USED BY RT-PCR METHOD

      SATO Kenjiro, HATTORI Atsuhiko, WADA Masaru, IGARASHI Junko, HARA Masayuki, HIRATA Kazuaki, IMAI Kiyoshi

        12   31 - 31   7 1997

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    • Ocular melatonin rhythms in the goldfish, Carassius auratus

      M Iigo, K Furukawa, A Hattori, R OhtaniKaneko, M Hara, T Suzuki, M Tabata, K Aida

      JOURNAL OF BIOLOGICAL RHYTHMS12 ( 2 ) 182 - 192   4 1997

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    • Hydroxyindole-O-methyltransferase activity assay using high-performance liquid chromatography with fluorometric detection: Determination of melatonin enzymatically formed from N-acetylserotonin and S-adenosyl-L-methionine

      MT Itoh, A Hattori, Y Sumi

      JOURNAL OF CHROMATOGRAPHY B692 ( 1 ) 217 - 221   4 1997

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    • メラトニン-不思議なホルモン?

      服部 淳彦

      化学と教育45 ( 5 ) 256 - 257   1997

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      Language：Japanese   Publisher：公益社団法人 日本化学会  

      DOI： 10.20665/kakyoshi.45.5_256

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    • メラトニンと進化-多彩な機能とその評価

      脳と精神の医学8   319 - 324   1997

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    • Regulation by guanine nucleotides and cations of melatonin binding sites in the goldfish brain

      M Iigo, R OhtaniKaneko, M Hara, A Hattori, H Takahashi, M Tabata, T Suzuki, K Aida

      BIOLOGICAL SIGNALS6 ( 1 ) 29 - 39   1 1997

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    • Retinal melatonin is not involved in corneal mitotic rhythms in the Japanese quail: Effects of formoguanamine hydrochloride and eye-lid suture

      T Oishi, Y Mohri, T Kaneko, M Sasaki, A Hattori, Y Obara, A Masuda

      JOURNAL OF PINEAL RESEARCH21 ( 3 ) 149 - 154   10 1996

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    • Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method

      S Yamada, M Takahashi, M Hara, A Hattori, T Sano, Y Ozawa, Y Shishiba, K Hirata, M Usui

      CLINICAL ENDOCRINOLOGY45 ( 3 ) 263 - 272   9 1996

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    • HORMONAL CHANGES IN PINEALECTOMIZED CHICKS WITH SPINAL DEFORMITY

      KATO Haruyasu, HATTORI Atsuhiko, WADA Masaru, AOKI Haruhito, HAMABE Masaki, SASAO Yutaka, WAKITA Masaaki

        11   49 - 49   8 1996

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    • PRESENCE OF PINEAL HORMONE, MELATIONIN, IN THE PLANT

      HATTORI Atsuhiko, MIGITAKA Hiro, ITOH Masanori, IIGO Masayuki, OHTANI-KANEKO Ritsuko, HARA Masayuki, TAKAHASHI Hidehito, SUZUKI Takuro

        37   150 - 150   3 1996

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    • 熱ショックストレスによる成長ホルモン遺伝子発現-培養ラット下垂体細胞を用いた解析

      聖マリアンナ医大誌24   6 - 15   1996

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    • H.pylori 実験における正常胃由来培養細胞(HM-1)の有用性

      消化器科22   149 - 154   1996

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    • MELATONIN AND ARYLALKYLAMINE N-ACETYLTRANSFERASE ACTIVITY IN THE SILKWORM, BOMBYX-MORI

      MT ITOH, A HATTORI, T NOMURA, Y SUMI, T SUZUKI

      MOLECULAR AND CELLULAR ENDOCRINOLOGY115 ( 1 ) 59 - 64   11 1995

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    • Melatonin binding sites in the brain of the Japanese newt, Cynops pyrrhogaster

      IIGO Masayuki, CHIBA Atsuhiko, HATTORI Atsuhiko, HARA Masayuki, OHTANI-KANEKO Ritsuko, TAKAHASHI Hidehito, SUZUKI Takuro

        10   56 - 56   10 1995

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    • EFFECTS OF TESTOSTERONE ON THE FUNCTION OF LH CELLS IN CASTRATED MALE RATS : ANALYSIS BY THE REVERSE HEMOLYTIC PLAQUE ASSAY

      HATTORI Atsuhiko, KAZAMA Yoshihiko, MIGITAKA Hiro, TAKAHASHI Hidehito, OHTANI-KANEKO Ritsuko, HARA Masayuki, IIGO Masayuki, SUZUKI Takuro

        10   66 - 66   10 1995

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    • EFFECTS OF PINEALECTOMY AND CONSTANT LIGHT EXPOSURE ON DAY-NIGHT CHANGES OF MELATONIN BINDING-SITES IN THE GOLDFISH BRAIN

      M IIGO, K FURUKAWA, A HATTORI, M HARA, R OHTANIKANEKO, T SUZUKI, M TABATA, K AIDA

      NEUROSCIENCE LETTERS197 ( 1 ) 61 - 64   9 1995

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    • DAY-NIGHT CHANGES IN MELATONIN LEVELS IN DIFFERENT ORGANS OF THE CRICKET (GRYLLUS-BIMACULATUS)

      MT ITOH, A HATTORI, Y SUMI, T SUZUKI

      JOURNAL OF PINEAL RESEARCH18 ( 3 ) 165 - 169   4 1995

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    • IDENTIFICATION OF MELATONIN IN PLANTS AND ITS EFFECTS ON PLASMA MELATONIN LEVELS AND BINDING TO MELATONIN RECEPTORS IN VERTEBRATES

      A HATTORI, H MIGITAKA, M IIGO, M ITOH, K YAMAMOTO, R OHTANIKANEKO, M HARA, T SUZUKI, RJ REITER

      BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL35 ( 3 ) 627 - 634   3 1995

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    • メラトニン投与によるサクラマス銀化制御の試み

      飯郷雅之, 須永史夫, 田畑満生, 生田和正, 北村章二, 服部淳彦, 原正幸, 高橋秀仁, 会田勝美

      日本水産学会大会講演要旨集1995   1995

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    • 後天性免疫不全症候群に合併したサイトメガロウイルス食道潰瘍の1例

        46   91 - 93   1995

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    • 暗期ラット血漿メラトニン濃度に及ぼす各種薬剤皮下投与の影響

      内田和秀

      聖マリアンナ医大誌23 ( 5 ) 1030 - 1034   1995

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    • 去勢雄ラット下垂体gonadotrophsのLH放出に対するテストステロンの影響-reverse hemolytic plaque assayによる解析-

      聖マリアンナ医大誌23   2121 - 2131   1995

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    • ウズラ胚の網膜形成過程におけるメラトニンの変化

      聖マリアンナ医大誌23   239 - 248   1995

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    • ニワトリ松果体除去による脊柱側わん発生と脊椎骨におけるメラトニンレセプターの検索

      聖マリアンナ医大誌23   853 - 861   1995

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    • Day-night changes in melatonin contents in the vitreous body and in vitro melatonin release from the retina of Japanese quail(Coturnix coturnix japonica).

      St. Marianna Med. J.23   833 - 842   1995

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    • Perioperative plasma melatonin levels in patients with cardiac and esophageal surgery.

      St. Marianna Med. J.23   292 - 298   1995

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    • MELATONIN INHIBITS LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) INDUCTION OF LH-RELEASE FROM FETAL-RAT PITUITARY-CELLS

      A HATTORI, DC HERBERT, MK VAUGHAN, K YAGA, RJ REITER

      NEUROSCIENCE LETTERS184 ( 2 ) 109 - 112   1 1995

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    • IDENTIFICATION OF MELATONIN IN DIFFERENT ORGANS OF THE CRICKET, GRYLLUS-BIMACULATUS

      MT ITOH, A HATTORI, Y SUMI, T SUZUKI

      ZOOLOGICAL SCIENCE11 ( 4 ) 577 - 581   8 1994

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    • CHARACTERISTICS, DAY-NIGHT CHANGES, SUBCELLULAR-DISTRIBUTION AND LOCALIZATION OF MELATONIN BINDING-SITES IN THE GOLDFISH BRAIN

      M IIGO, M KOBAYASHI, R OHTANIKANEKO, M HARA, A HATTORI, T SUZUKI, K AIDA

      BRAIN RESEARCH644 ( 2 ) 213 - 220   5 1994

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    • THE PINEAL MELATONIN RHYTHM AND ITS REGULATION BY LIGHT IN A SUBTERRANEAN RODENT, THE VALLEY POCKET GOPHER (THOMOMYS BOTTAE)

      RJ REITER, MN REITER, A HATTORI, K YAGA, DC HERBERT, L BARLOWWALDEN

      JOURNAL OF PINEAL RESEARCH16 ( 3 ) 145 - 153   4 1994

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    • 366 ラット松果体器官培養によるメラトニン分泌動態に関する研究

      房間 茂由, 石塚 文平, 萩庭 一元, 大野 祐子, 石田 徳人, 雨宮 章, 服部 淳彦, 飯郷 雅之, 鈴木 卓朗

      日本産科婦人科學會雜誌46   "S - 310"   20 2 1994

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      Publisher：社団法人日本産科婦人科学会  

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    • 妊娠および授乳ラットにおけるGnRH associated peptideのプロラクチン放出抑制効果-reverse hemolytic plaque assayよる解析-

      聖マリアンナ医大誌22   397 - 406   1994

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    • 下垂体腺腫の機能病理学的手枝(1)-Reverse hemolytic plaque assay法-

        31   255 - 258   1994

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    • Concentration of melatonin and enzymes of its biosynthesis of the epiphysis of silver fox male and females.

      Collection of the Institute of Cytology and Genetics : Endocrinology and Reproduction of fur Bearing Animals.2   76 - 83   1994

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    • The circadian dynamics of the melatonin concentration in silver fox pineal gland, plasma and retina.

      Sechenov Physiol. J.80   38 - 41   1994

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    • Peculiartites of melatonin biosynthesis in the pineal gland of relatively wild and domesticated silver foxes, Vulpes fulvus.

      J. Evol. Biochem. Physiol.30   338 - 343   1994

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    • EFFECTS OF TESTOSTERONE AND LUTEINIZING-HORMONE-RELEASING HORMONE ON OCCURRENCE OF UBIQUITIN IN THE NUCLEUS OF RAT LH CELLS IN-VITRO

      R OHTANIKANEKO, Y WADA, A HATTORI, K TAKADA, M HARA, M IIGO, K IMAI, T SUZUKI

      ENDOCRINE2 ( 1 ) 69 - 73   1 1994

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    • PHOTOTRANSDUCTION-RELATED CIRCADIAN CHANGES IN INDOLEAMINE METABOLISM IN THE CHICK PINEAL-GLAND IN-VIVO

      JH SUN, RJ REITER, A HATTORI, K YAGA, DC HERBERT, ATC TSIN

      JOURNAL OF PINEAL RESEARCH15 ( 3 ) 132 - 137   10 1993

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    • UNUSUAL RESPONSES OF NOCTURNAL PINEAL MELATONIN SYNTHESIS AND SECRETION TO SWIMMING - ATTEMPTS TO DEFINE MECHANISMS

      K YAGA, DX TAN, RJ REITER, LC MANCHESTER, A HATTORI

      JOURNAL OF PINEAL RESEARCH14 ( 2 ) 98 - 103   3 1993

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    • 培養血管内皮細胞の線溶反応におけるtype(]G0004[)コラーゲンの影響

      聖マリアンナ医大誌21   1209 - 1212   1993

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    • 血管内皮細胞からのPAI-1遊離抑制-高分子蛋白分解酵素阻害薬による基礎的検討-

      聖マリアンナ医大誌21   268 - 270   1993

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    • 個々の下垂体細胞におけるエキソサイトーシスによるホルモン放出量の解析

      生理研年報14   219 - 220   1993

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    • 再閉塞におけるPAI-1の意義とその抑制法の検討-培養血管内皮細胞の反応について-

      医学と薬学29   73 - 76   1993

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    • QUANTITATIVE MORPHOLOGICAL ANALYSIS OF THE PITUITARY-GLAND IN PROTEIN-CALORIE MALNOURISHED RATS

      DC HERBERT, T YASHIRO, T MURAKI, T OKANO, A HATTORI, T SUZUKI

      ANATOMICAL RECORD235 ( 1 ) 121 - 125   1 1993

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    • In vivo and in vitro response of the hypophysis of protein-calorie malnourished rats to luteinizing hormone releasing hormone.

      Biomed. Res.4   215 - 226   1993

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    • Melatonin content in tissues of relatively wild and domesticated silver fox Vulpes fulvus.

      J. Evol. Biochem. Physiol.29   482 - 486   1993

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    • INCREASE IN UBIQUITIN-IMMUNOREACTIVE NUCLEI IN RAT PITUITARY LUTEINIZING-HORMONE CELLS AFTER CASTRATION

      R OHTANIKANEKO, A HATTORI, M HARA, M IIGO, K TAKADA, T SUZUKI

      ENDOCRINOLOGY130 ( 5 ) 2545 - 2548   5 1992

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    • 蛋白分解酵素阻害薬Gabexate Mesilate添加による培養血管内皮細胞からのPAI-1放出抑制の検討

      今原佐知子

      聖マリアンナ医大誌20   134 - 139   1992

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    • 組織プラスミノーゲンアクチベーター(tPA)添加による培養血管内皮細胞からのインヒビター(PAI-1)遊離

      鴨川旭

      聖マリアンナ医大誌20   214 - 217   1992

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    • Reverse hemolytic plaque assayを用いた下垂体線腫の解析

      病理と臨床10   988 - 993   1992

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    • 雄ラット個々の下垂体細胞におけるLHRH刺激後のLH放出動態-plaque assayによる解析-

      友池 英樹, 服部 淳彦, 松田 仁

      聖マリアンナ医大誌20 ( 6 ) 1062 - 1070   1992

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    • REVERSE HEMOLYTIC PLAQUE-ASSAY - ELECTRON-MICROSCOPIC OBSERVATION OF PLAQUE-FORMING SINGLE ADENOMA CELLS IN GH PRODUCING ADENOMAS

      S YAMADA, T AIBA, A HATTORI, T SUZUKI, SL ASA, K KOVACS

      PATHOLOGY RESEARCH AND PRACTICE187 ( 5 ) 546 - 551   6 1991

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    • 蛋白分解酵素阻害薬による血管内皮細胞由来線溶因子放出制御の検討

      聖マリアンナ医大誌19   343 - 346   1991

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    • 黄体形成ホルモン放出ホルモンの比較内分泌学

      ペプチドホルモン ホルモンの生物科学10,学会出版センター (東京)   109 - 140   1991

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    • Rythms of blood melatonin in individual Japanese quail(Coturnix coturnix japonica).

      St. Marianna Med. J.18   241 - 248   1990

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    • 唾液腺Receptor,(]G0004[).細胞,組織別レセプター論.

      日本臨床47   767 - 770   1989

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    • FINE-STRUCTURAL HETEROGENEITY OF PRL CELLS IN THE RAT ANTERIOR-PITUITARY GLAND - ITS RELATIONSHIP TO HORMONE-SECRETION

      T YASHIRO, A HATTORI, T SUZUKI

      ANATOMICAL RECORD220 ( 4 ) A107 - A107   4 1988

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    • ラット下垂体前葉における細胞間相互作用の証明に関する形態学的アプローチ

      河野研研究年報38   33 - 42   1988

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    • 個々の細胞からのホルモン放出量測定法-reverse hemolytic plaque assay-

      生体の科学39   510 - 512   1988

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    • Functional and morphological heterogeneity of prolactin cells in the rat.

      Kyoto Prolaction Conference Monograph3.   61 - 70   1988

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    • EFFECTS OF INTRACRANIALLY IMPLANTED CHOLECYSTOKININ AND SUBSTANCE-P ON SERUM CONCENTRATIONS OF GONADOTROPINS, PROLACTIN AND THYROID STIMULATING HORMONE IN THE RAT

      H UEMURA, A HATTORI, M WADA, H KOBAYASHI

      ZOOLOGICAL SCIENCE4 ( 2 ) 331 - 337   4 1987

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    • Fine structural and immunohistochemical identification of TSH and LH cells in the C57BL mouse anterior pituiary gland.

      Jikeikai Med. J.34   479 - 487   1987

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    • CIRCADIAN VARIATION IN MELATONIN RELEASE FROM THE EYE OF JAPANESE-QUAIL

      A HATTORI, M WADA, Y SONODA

      ZOOLOGICAL SCIENCE3 ( 6 ) 1087 - 1087   12 1986

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    • EFFECTS OF 2 KINDS OF CHICKEN LUTEINIZING-HORMONE-RELEASING HORMONE (LH-RH), MAMMALIAN LH-RH AND ITS ANALOGS ON THE RELEASE OF LH AND FSH IN JAPANESE-QUAIL AND CHICKEN

      A HATTORI, S ISHII, M WADA

      GENERAL AND COMPARATIVE ENDOCRINOLOGY64 ( 3 ) 446 - 455   12 1986

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    • DIFFERENT MECHANISMS CONTROLLING FSH AND LH-RELEASE IN JAPANESE-QUAIL (COTURNIX-COTURNIX JAPONICA) - EVIDENCE FOR AN INHERENTLY SPONTANEOUS RELEASE AND PRODUCTION OF FSH

      A HATTORI, S ISHII, M WADA

      JOURNAL OF ENDOCRINOLOGY108 ( 2 ) 239 - 245   2 1986

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    • Actions of two intrinsic LHRHs on release of gonadotropins in quail : deferent structures but the same response.

      Pars Distalis of the Pituitary Gland. Yoshimura, F. and Gorbman, A. (eds)Elsevier   231 - 237   1986

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    • INITIAL PROCESS OF PHOTOSTIMULATED LH-SECRETION IN QUAIL - FROM EPISODIC RELEASE TO CONSTANT SECRETION

      M WADA, A HATTORI, F HATANAKA

      ZOOLOGICAL SCIENCE2 ( 6 ) 982 - 982   1985

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    • EFFECTS OF CHICKEN LHRH ON LH-RELEASE FROM QUAIL PITUITARY INVITRO BY VARIOUS MODES OF ITS APPLICATION WITH DIFFERENT FREQUENCIES, DURATIONS AND DOSES

      A HATTORI, S ISHII, M WADA

      ZOOLOGICAL SCIENCE2 ( 6 ) 982 - 982   1985

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    • EFFECTS OF CHICKEN (GLN8)-LUTEINIZING AND MAMMALIAN (ARG8)-LUTEINIZING HORMONE-RELEASING HORMONES ON THE RELEASE OF GONADOTROPINS INVITRO AND INVIVO FROM THE ADENOHYPOPHYSIS OF JAPANESE QUAIL

      A HATTORI, S ISHII, M WADA, K MIYAMOTO, Y HASEGAWA, M IGARASHI, S SAKAKIBARA

      GENERAL AND COMPARATIVE ENDOCRINOLOGY59 ( 1 ) 155 - 161   1985

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    • ANNUAL CHANGES IN PLASMA GONADOTROPINS AND SEX STEROID IN THE WHITE IBIS IN CAPTIVITY

      S ISHII, A HATTORI, H SAKAI, S WAKABAYASHI, M WADA

      ZOOLOGICAL SCIENCE1 ( 6 ) 974 - 974   1984

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    • EFFECTS OF MET-ENKEPHALIN AND CHOLECYSTOKININ (CCK4) ON SERUM LH AND PRL CONCENTRATIONS

      H UEMURA, M WADA, A HATTORI, H KOBAYASHI

      ZOOLOGICAL SCIENCE1 ( 6 ) 979 - 979   1984

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    • STIMULATION OF FSH AND LH RELEASES BY 2 CHICKEN LHRHS AND MAMMALIAN LHRH INVITRO AND INVIVO

      A HATTORI, S ISHII

      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY20 ( 6B ) 1548 - 1548   1984

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    • RECEPTIVITY OF QUAIL ADENOHYPOPHYSIS TO VARIOUS LUTEINIZING-HORMONE-RELEASING HORMONES (LHRHS)

      A HATTORI, S ISHII, K MIYAMOTO, Y HASEGAWA, M IGARASHI, M WADA

      ZOOLOGICAL SCIENCE1 ( 6 ) 974 - 974   1984

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    • A DIFFERENT CONTROL MECHANISM IN FSH AND LH SECRETIONS OF QUAIL

      A HATTORI, S ISHII, M WADA

      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY20 ( 6B ) 1548 - 1548   1984

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    • Avian gonadotropin-releasing hormones.

      Ishii Susumu, Hattori Atsuhiko, Wada Masaru, MIyamato Kaoru, Hasegawa Yoshihisa, Igarashi Masao

      Evolutionary Aspects of Gonadotropins. Gunma Univ. (ed)Center for Academic Publications Japan21   79 - 91   1984

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    • LHRHの分子進化と種特異性

      服部 淳彦

      化学と生物21 ( 9 ) 567 - 568   1983

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      Other Link： http://search.jamas.or.jp/link/ui/1984081453

    • 培養血管内皮細胞の線溶系応答からみたt-PA/UK併用の利点

      医学と薬学30   1131 - 1133  

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    Books and Other Publications

    • 自然界におけるメラトニンの分布

      メラトニン研究の最新の進歩  2004 

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    • 脳内物質メラトニン

      朝日出版社  1996 

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    • 奇跡のホルモン メラトニン

      講談社(監修)  1995 

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    Presentations

    • マウスにおける内因性メラトニン代謝産物N-acetyl-5-methoxykynuramine(AMK)と海馬における糖取込みとの関連.

      張賢, 丸山雄介, 岩下洸, 服部淳彦

      日本動物学会関東支部第71回大会  9 3 2019 

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    • メラトニン(MEL)はキンギョの脳における糖の取込みを促進する.

      岡田玲那, 渡辺数基, 丸山雄介, 服部淳彦

      日本動物学会関東支部第71回大会  9 3 2019 

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      Language：Japanese   Presentation type：Poster presentation  

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    • キンギョの鱗においてノルアドレナリン(NA)の刺激で合成されるN-acetyl-5-methoxykynuramine(AMK)は骨芽細胞を活性化する.

      河村平, 小泉なぎさ, 丸山雄介, 服部淳彦

      日本動物学会関東支部第71回大会  9 3 2019 

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    • メラトニン研究の最新情報 Invited

      服部淳彦

      日本抗加齢医学会2018年度 第4回メディアセミナー  18 2 2019 

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      Language：Japanese   Presentation type：Media coverage  

      Venue：東京  

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    • ゼブラフィッシュ鱗を用いた骨折修復過程におけるライブイメージング解析.

      小林静静, 近藤真央, 山森汐莉, 鈴木信雄, 服部淳彦, 北村敬一郎, 山口正晃, 小林功

      日本分子生物学会第41回年会  28 11 2018 

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      Language：Japanese  

      Venue：横浜  

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    • 長期記憶誘導作用を持つメラトニンの脳内代謝産物AMK Invited

      服部淳彦

      第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会  16 11 2018 

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      Language：Japanese   Presentation type：Oral presentation (invited, special)  

      Venue：東京  

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    • マウスの長期記憶形成に関与する内因性のメラトニン代謝産物 N-acetly-5- methoxykynuramine (AMK).

      岩下洸, 丸山雄介, 張賢, 松本幸久, 千葉篤彦, 服部淳彦

      第43回日本比較内分泌学会大会及びシンポジウム  9 11 2018 

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    • 夜間のメラトニンはインスリンを介さずにキンギョの糖代謝を調節している.

      渡辺数基, 中野真樹, 丸山雄介, 服部淳彦

      第43回日本比較内分泌学会大会及びシンポジウム  9 11 2018 

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    • α-MSH は血漿カルシトニン濃度を上昇させてカルシウム代謝に関与する.

      鈴木信雄, 五十里雄大, 小林勇喜, 水澤寛太, 高橋明義, 木谷洋一郎, 関口俊男, 遠藤雅人, 神戸川明, 朝比奈潔, 田渕圭章, Thumronk Amornsakun, 服部淳彦

      第43回日本比較内分泌学会大会及びシンポジウム  9 11 2018 

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      Venue：仙台  

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    • メラトニンと睡眠・抗加齢効果 Invited

      服部淳彦

      日本抗加齢協会セミナー  23 9 2018 

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      Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

      Venue：フジテレビ１階マルチシアター  

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    • Effects of low-intensity pulsed ultrasound on osteoclastogenesis with goldfish scales having both osteoclasts and osteoblasts

      Nobuo Suzuki, Taizo Hanmoto, Yoshiaki Tabuchi, Sachiko Yano, Mika Ikegame, Kei-ichiro Kitamura, Toshio Sekiguchi, Isao Kobayashi, Azusa Seki, Atsuhiko Hattori

      日本宇宙生物科学会第32回大会  21 9 2018 

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    • 骨粗鬆症モデルラットにおける副甲状腺ホルモンとメラトニンの併用効果

      池亀美華, 田中みか子, 江尻貞一, 服部淳彦, 高尾亮子, 内部健太, 岡村裕彦

      第60回歯科基礎医学会総会  5 9 2018 

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    • メラトニンMT1/MT2受容体アゴニストによる学習記憶機能の増強作用

      佐野真広, 岩下洸, 梅木智裕, 中村華子, 吉川史紘, 服部淳彦, 千葉篤彦

      第29 回 日本行動神経内分泌研究会  5 9 2018 

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    • アルツハイマー様の学習記憶障害を示すマウスに対するメラトニンの学習記憶機能の改善効果

      梅木智裕, 岩下洸, 佐野真広, 中村華子, 吉川史紘, 服部淳彦, 千葉篤彦

      第29 回 日本行動神経内分泌研究会  5 9 2018 

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    • マウスにおける内因性のメラトニン代謝産物N-acetly-5-methoxykynuramine (AMK)と長期記憶形成との関連

      岩下洸, 丸山雄介, 張賢, 松本幸久, 千葉篤彦, 服部淳彦

      第29回日本行動神経内分泌研究会  5 9 2018 

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    • 赤外・ラマン分光による硬骨魚ウロコの構造解析

      奈良雅之, 丸山雄介, 服部淳彦

      第27回バイオイメージング学会学術集会  3 9 2018 

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    • 「学習・記憶」－加齢性記憶障害の回復作用 Invited

      服部淳彦

      第10回抗加齢内分泌研究会  2 9 2018 

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      Venue：東京  

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    • Melatonin, the hormone of gloom: Implications in the semilunar-synchronized spawning of the grass puffer. International conference

      Hironori Ando, Md. Shahjahan, Takashi Kitahashi, Atsuhiko Hattori

      AOSCE2018 University of Sydney  8 7 2018 

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    • 内因性のメラトニン代謝産物N-acetyl-5-methoxykyuramine(AMK)による長期記憶誘導作用

      岩下光, 松本幸久, 丸山雄介, 張賢, 千葉篤彦, 服部淳彦

      第18回日本抗加齢医学会総会  25 5 2018 

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    • 象牙質や象牙質結晶に対するメラトニンの影響

      三島弘幸, 服部淳彦, 鈴木信雄, 松本 敬, 池亀美華, 見明康雄, 松本由樹

      第123回日本解剖学会総会・全国学術集会  28 3 2018 

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    • 魚類の骨代謝に対する黒色素胞刺激ホルモンの影響：in vivo及びin vitroによる解析

      鈴木信雄, 石津偉統, 木谷洋一郎, 五十里雄大, 関口俊男, 北村敬一郎, 遠藤雅人, 服部淳彦, 水澤寛太, 高橋明義

      平成30年度日本水産学会春季大会  26 3 2018 

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    • カイコガ幼虫と成虫の頭部におけるメラトニン合成経路関連物質の昼夜変化

      古屋瑠菜, 丸山雄介, 服部淳彦

      日本動物学会関東支部 第70回大会  21 3 2018 

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    • フッ素の硬骨魚類の骨代謝に与える影響

      鈴木信雄, 佐藤将之, 谷内口孝治, 木谷洋一郎, 関口俊男, 五十里雄大, 小木曽正造, 田渕圭章, 三島弘幸, 見明康雄, 本橋慶一, 矢口行雄, 服部淳彦

      第2回富山湾研究会  5 3 2018 

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    • α-melanocyte-stimulating hormone functions to calcium metabolism in goldfish. International conference

      Ishizu, H, Sekiguchi, T, Ikari, T, Kitamura, K, Kitani, Y, Endo, M, Urata, M, Hattori, A, Mizusawa, K, Takahashi, A, Suzuki, N

      International Symposium “Environmental researches in northern Japan Sea and related regions”  3 3 2018 

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    • Plasma cortisol levels decreases in marine fishes kept in deep ocean water. International conference

      Ikari, T, Kitani, Y, Ogiso, S, Sekiguchi, T, Toyohara, C, Nakayama, Y, Maruyama, Y, Hattori, A, Tabuchi, Y, Kambegawa, A, Asahina, K, Fukushi, K, Suzuki, N

      International Symposium “Environmental researches in northern Japan Sea and related regions”  3 3 2018 

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    • LIPUSに対する骨芽細胞及び破骨細胞の応答:キンギョのウロコを用いたin vitro及びin vivoの解析

      鈴木信雄, 半本泰三, 田渕圭章, 近藤 隆, 池亀美華, 北村敬一郎, 関口俊男, 小林 功, 関あずさ, 服部淳彦

      第21回超音波骨折治療研究会  20 1 2018 

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    • メラトニンの老化抑制効果 Invited

      服部淳彦

      脳心血管抗加齢研究会2017  16 12 2017 

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      Venue：大阪  

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    • 老化抑制ホルモンとしてのメラトニン Invited

      服部淳彦

      日本抗加齢医学会－専門医・指導士認定委員会講習会  10 12 2017 

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    • 軟骨組織におけるメラトニン合成とその受容体発現は慨日リズムを持ち、軟骨細胞の代謝に影響を及ぼす

      服部高子, FU Shanqi, 桑原実穂, 内田揺子, 近藤星, 林大智, 下村侑司, 高垣安紗美, 西田崇, 丸山雄介, 池亀美華, 服部淳彦, 久保田聡

      第90回日本生化学会大会  7 12 2017 

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    • コオロギの長期記憶形成能の日内および概日変化と昼夜で異なるメラトニン脳内代謝産物の長期記憶誘導効果

      佐藤紀之, 松本幸久, 丸山雄介, 服部淳彦

      第42回日本比較内分泌学会大会  18 11 2017 

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    • メラトニン産生能を持つマウスにおけるメラトニン脳内代謝産物N-acetyl-5-methoxykyuramine(AMK)の長期記憶誘導作用

      岩下洸, 松本幸久, 丸山雄介, 張賢, 千葉篤彦, 服部淳彦

      第42回日本比較内分泌学会大会  18 11 2017 

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    • 黒色素胞刺激ホルモンはキンギョの再生ウロコの骨芽細胞と破骨細胞を活性化する

      石津偉統, 関口俊男, 五十里雄大, 木谷洋一郎, 北村敬一郎, 浦田 慎, 遠藤雅人, 服部淳彦, 水澤寛太, 高橋明義, 鈴木信雄

      第42回日本比較内分泌学会およびシンポジウム  17 11 2017 

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    • コオロギにおける長期記憶形成能の概日変化とメラトニン及びその脳内代謝産物の長期記憶誘導効果

      佐藤紀之, 松本幸久, 丸山雄介, 服部淳彦

      第24回時間生物学会学術大会  28 10 2017 

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    • 特発性正常圧水頭症患者の髄液排除試験後にみられた起床時の尿中メラトニン濃度の上昇

      Tamamongood Thiparpa, 丸山雄介, 山本信二, 大木純, 田畑均, 服部淳彦

      日本脳神経外科学会第76回学術総会  12 10 2017 

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    • Effect of circadian rhythm synchronous factor melatonin on structure, composition, and calcification of dentin and odontoblasts. International conference

      Mishima, H, Tanabe, S, Hattori, A, Suzuki, N, Kakei, M, Matumoto, T, Ikegame, M, Miake, Y, Matsumoto, Y

      The 14th International Symposium on Biomineralization  9 10 2017 

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    • Effects of α-melanocyte-stimulating hormone on osteoblasts and osteoclasts in the regenerating scales of goldfish. International conference

      Ishizu, H, Sekiguchi, T, Ikari, T, Kitamura, K, Kitani, Y, Endo, M, Urata, M, Hattori, A, Mizusawa, K, Takahashi, A, Suzuki, N

      3rd International Symposium “International Collaboration Research Base for Reaction of Atmosphere-Marine-Ecosystem Caused by Aerosol”  9 10 2017 

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    • Stress response of Noto deep ocean water in marine fishes. International conference

      Ikari, T, Kitani, Y, Ogiso, S, Sekiguchi, T, Toyohara, C, Nakayama, Y, Maruyama, Y, Hattori, A, Tabuchi, Y, Kambegawa, A, Asahina, K, Fukushi, K, Suzuki, N

      3rd International Symposium “International Collaboration Research Base for Reaction of Atmosphere-Marine-Ecosystem Caused by Aerosol”  9 10 2017 

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    • 概説と学習・記憶－メラトニンの脳内代謝産物が持つ長期記憶誘導作用 Invited

      服部淳彦

      日本動物学会第88回大会  22 9 2017 

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      Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

      Venue：富山  

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    • 記憶力が低下した加齢マウスにおけるメラトニン脳内代謝産物の長期記憶誘導作用

      岩下光, 松本幸久, 丸山雄介, 千葉篤彦, 服部淳彦

      日本動物学会第88回大会  21 9 2017 

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    • メラトニンによる長期記憶の誘導効果は投与時刻により異なる

      佐藤紀之, 松本幸久, 服部淳彦

      日本動物学会第88回大会  21 9 2017 

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      Venue：富山  

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    • 赤外・ラマン分光による魚類ウロコの状態解析

      奈良雅之, 丸山雄介, 服部淳彦

      日本分析化学会  12 9 2017 

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    • 就寝前のブルーライトカット眼鏡装用によりインスリン抵抗性が改善

      柳川達生, 綾木雅彦, 服部淳彦, 永井紀博, 根岸一乃, 坪田一男

      日本睡眠学会第42回定期学術集会  29 6 2017 

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      Venue：パシフィコ横浜  

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    • 概日リズム同調因子メラトニンによる象牙質や象牙芽細胞の組織構造への影響

      三島弘幸, 田辺咲貴, 服部淳彦, 鈴木信雄, 筧光男, 松本 敬, 池亀美華, 見明康雄, 松本由樹

      第35回化石研究会総会・学術大会  3 6 2017 

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      Venue：福井県立恐竜博物館  

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    • ジヒドロキシインドールカルボン酸を用いたメラニン重合評価系の検討とプラセンタにおける美白有効成分の同定

      丸山雄介, 宮内大治, 横川剛, 服部淳彦

      第17回日本抗加齢医学会総会  2 6 2017 

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    • メラトニン代謝産物であるN-acetyl-5-methoxykyuramine(AMK)とその類似物質による長期記憶の誘導効果－コオロギをモデル動物として

      松本幸久, 丸山雄介, 松本千尋, 影近弘之, 松野弘幸, 岩下光, 千葉篤彦, 服部淳彦

      第17回日本抗加齢医学会総会  2 6 2017 

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    • メラトニンの脳内代謝産物であるN-acetyl-5-methoxykyuramine(AMK)による老齢マウスにおける長期記憶誘導作用

      岩下光, 松本幸久, 丸山雄介, 千葉篤彦, 服部淳彦

      第17回日本抗加齢医学会総会  2 6 2017 

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      Venue：東京国際フォーラム, 東京  

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    • メラトニンによる象牙質や象牙芽細胞への影響

      三島弘幸, 田辺咲貴, 服部淳彦, 鈴木信雄, 松本 敬, 池亀美華, 見明康雄

      第122回日本解剖学会総会・全国学術集会  28 3 2017 

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      Venue：長崎大学  

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    • 魚類の骨代謝に対する黒色素胞刺激ホルモンの影響

      鈴木信雄, 木谷洋一郎, 五十里雄大, 石津偉統, 小木曽正造, 関口俊男, 服部淳彦, 高橋明義

      平成29年度日本水産学会春季大会  26 3 2017 

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      Venue：東京海洋大学品川キャンパス，東京都  

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    • Effects of mercury on osteoclasts and osteoblasts in the scales of the nibbler fish (marine teleost). International conference

      Yachiguchi, K, Sekiguchi, T, Hattori, A, Yamamoto, M, Kitamura, K, Tabuchi, Y, Suzuki, N

      Joint International Symposium Institute of Nature and Environmental Technology  28 2 2017 

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    • Sodium fluoride acts on osteoclasts and osteoblasts and disrupts calcium metabolism in goldfish. International conference

      Sato, M, Hanmoto, T, Yachiguchi, K, Tabuchi, Y, Kondo, T, Endo, M, Kitani, Y, Sekiguchi, T, Urata, M, Srivastav, A.K, Mishima, H, Hattori, A, Suzuki, N

      Joint International Symposium Institute of Nature and Environmental Technology  28 2 2017  Kanazawa University

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      Venue：Ishikawa, Japan  

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    • Effect of sardine procalcitonin amino-terminal cleavage peptide on osteoblasts of the goldfish scales. International conference

      Kase, Y, Ikari, T, Sekiguchi, T, Sato, M, Kawada, T, Matsubara, S, Satake, H, Sasayama, Y, Endo, M, Hattori, A, Watanabe, T, Suzuki, N

      Joint International Symposium Institute of Nature and Environmental Technology  28 2 2017  Kanazawa University

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      Venue：Ishikawa, Japan  

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    • Deep ocean water influences on fish physiology: analysis of plasma cortisol levels. International conference

      Ikari, T, Kitani, Y, Sato, M, Ogiso, S, Toyohara, C, Hattori, A, Kambegawa, A, Asahina, K, Fukushi, K, Suzuki, N

      Joint International Symposium Institute of Nature and Environmental Technology  28 2 2017  Kanazawa University

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      Venue：Ishikawa, Japan  

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    • Low-intensity pulsed ultrasound moderately activates osteoclasts: Analysis with goldfish scales as a model of bone. International conference

      Hanmoto, T, Tabuchi, Y, Ikegame, M, Kondo, T, Kitamura, K, Endo, M, Mishima, H, Sekiguchi, T, Urata, M, Seki, A, Yano, S, Hattori, A, Suzuki, N

      Joint International Symposium Institute of Nature and Environmental Technology  28 2 2017  Kanazawa University

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      Venue：Ishikawa, Japan  

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    • メラトニンの脳内代謝産物であるN-acetyl-5-methoxykyuramine(AMK)のマウスにおける長期記憶誘導作用

      岩下光, 松本幸久, 丸山雄介, 千葉篤彦, 服部淳彦

      第 41回日本比較内分泌学会大及びシンポジウム  9 12 2016 

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      Language：Japanese   Presentation type：Oral presentation (general)  

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    • メラトニンによるインスリンを介さない血漿グルコース濃度低下作用－キンギョを用いて

      渡辺数基, 中野真樹, 服部淳彦

      第 41回日本比較内分泌学会大及びシンポジウム  9 12 2016 

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      Language：Japanese   Presentation type：Oral presentation (general)  

      Venue：北里大学、神奈川  

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    • 繁殖後期のキンギョにおける血漿カルシウム濃度の低下と鱗で産生されるメラトニンとの関連

      松岡里沙, 丸山雄介, 鈴木信雄, 服部淳彦

      第 41回日本比較内分泌学会大及びシンポジウム  9 12 2016 

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      Language：Japanese   Presentation type：Poster presentation  

      Venue：北里大学, 神奈川県  

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    • Melatonin metabolites rescue age-related momory impairment in the criket. International conference

      Yukihisa Matsumoto, Yusuke Maruyama, Chihiro Matsumoto, Hikaru Iwashita, Atsuhiko Chiba, Atsuhiko Hattori

      The Joint Meeting of the 22nd International Congress of Zoology & the 87th meeting of the Zoological Society of Japan  14 11 2016  Okinawa Convention Center

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      Language：English   Presentation type：Poster presentation  

      Venue：Okinawa, Japan  

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    • Effects of low-intensity pulsed ultrasound on osteoclasts: Analysis with goldfish scales as a model of bone. International conference

      Hanmoto, T, Tabuchi, Y, Ikegame, M, Kondo, T, Kitamura, K, Endo, M, Mishima, H, Sekiguchi, T, Urata, M, Seki, A, Yano, S, Hattori, A, Suzuki, N

      The Joint Meeting of the 22nd International Congress of Zoology & the 87th meeting of the Zoological Society of Japan  14 11 2016  Okinawa Convention Center

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      Language：English   Presentation type：Poster presentation  

      Venue：Okinawa, Japan  

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    • Suppressive effects of melatonin on osteoclastic function in chick calvaria. International conference

      Masaki Nakano, Mika Ikegame, Nobuo Suzuki, Atsuhiko Hattori

      14 11 2016 

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      Language：English   Presentation type：Poster presentation  

      Venue：Okinawa Convention Center, Okinawa, Japan  

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    • Effects of deep ocean water on fish physiology with special reference to stress hormones. International conference

      Ikari, T, Kitani, Y, Sato, M, Ogiso, S, Toyohara, C, Hattori, A, Kambegawa, A, Asahina, K, Fukushi, K, Suzuki, N

      The Joint Meeting of the 22nd International Congress of Zoology & the 87th meeting of the Zoological Society of Japan  14 11 2016 

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      Language：English   Presentation type：Poster presentation  

      Venue：Okinawa Convention Center, Okinawa, Japan  

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    • Sardine procalcitonin amino-terminal cleavage peptide is bioactive in osteoblasts of goldfish scales. International conference

      Kase, Y, Ikari, T, Sekiguchi, T, Sato, M, Kawada, T, Matsubara, S, Satake, H, Sasayama, Y, Endo, M, Hattori, A, Watanabe, T, Suzuki, N

      The Joint Meeting of the 22nd International Congress of Zoology & the 87th meeting of the Zoological Society of Japan  14 11 2016 

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      Language：English   Presentation type：Poster presentation  

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    • Effects of sodium fluoride on calcium metabolism in goldfish, Carassius auratus. International conference

      Sato, M, Hanmoto, T, Yachiguchi, K, Tabuchi, Y, Kondo, T, Endo, M, Kitani, Y, Sekiguchi, T, Urata, M, Srivastav, A.K, Mishima, H, Hattori, A, Suzuki, N

      The Joint Meeting of the 22nd International Congress of Zoology & the 87th meeting of the Zoological Society of Japan  14 11 2016 

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      Language：English   Presentation type：Poster presentation  

      Venue：Okinawa Convention Center, Okinawa, Japan  

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    • Both inorganic mercury and methylmercury influence on osteoclasts and osteoblasts in the scales of the marine teleost. International conference

      Yachiguchi, K, Sekiguchi, T, Hattori, A, Yamamoto, M, Kitamura, K, Tabuchi, Y, Suzuki, N

      The Joint Meeting of the 22nd International Congress of Zoology & the 87th meeting of the Zoological Society of Japan  14 11 2016 

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      Language：English   Presentation type：Poster presentation  

      Venue：Okinawa Convention Center, Okinawa, Japan  

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    • 睡眠を支えるメラトニン Invited

      服部淳彦

      日本抗加齢医学会北海道研究会  30 10 2016 

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      Language：Japanese   Presentation type：Oral presentation (invited, special)  

      Venue：札幌  

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    Professional Memberships

    Works

    • 内分泌撹乱物質の環境リスク

      2001

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    • 食素材としての植物由来の機能性成分の探索

      1998
      -
      2000

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    • 各種食用植物におけるメラトニンの探索

      1996
      -
      1998

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    Research Projects

    • メラトニン代謝産物AMKによる脳内炎症制御に着目した新たな認知症予防基盤の構築

      日本学術振興会  科学研究費助成事業 

      渡辺 数基, 小笠原 康悦, 平山 順, 渡辺 靖章, 服部 淳彦

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      4 2025 - 3 2029

      Grant number：25K03041

      Grant amount：\18720000 （ Direct Cost: \14400000 、 Indirect Cost：\4320000 ）

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    • Study on prevention of bone disease using fish induced hyperglycemia: Effect of food containing melatonin.

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

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      4 2023 - 3 2026

      Grant number：23K10933

      Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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    • 長期記憶誘導効果をもつメラトニン代謝産物AMKの加齢変化と機能性食品への展開

      日本学術振興会  科学研究費助成事業 

      服部 淳彦, 渡辺 数基

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      4 2022 - 3 2025

      Grant number：22K11823

      Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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    • 骨格筋における代謝異常・サルコペニア肥満と歯周炎の関わり-健康長寿を目指して-

      文部科学省/日本学術振興会 

      片桐 さやか, 鈴木 敏彦, 高橋 宏和, 廣田 朝光, 片桐 さやか, 服部 淳彦

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      2020 - 2022

      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 加齢に伴う長期記憶障害を回復させるメラトニン脳内代謝産物の効果と健康食品への展開

      文部科学省/日本学術振興会 

      服部 淳彦, 服部 淳彦

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      2018 - 2020

      Authorship：Principal investigator  Grant type：Competitive

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    • Novel action of melanocyte-stimulating hormone on bone: Analysis using fish scales with a high regeneration ability

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      Suzuki Nobuo, Hattori Atsuhiko

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      4 2016 - 3 2019

      Grant number：16K07871

      Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

      The purpose of this study is to analyze the novel action of melanocyte-stimulating hormone (MSH) on bone metabolism using fish scales as a bone model. In this study, we analyzed the effects of MSH on bone metabolism in vivo and in vitro using regenerating scales and demonstrated that MSH promotes osteoclastic and osteoblastic activity. In addition, we found that MSH promotes the secretion of calcitonin, which is involved in calcium metabolism. Furthermore, next-generation sequencing analyses were performed to investigate the differentiation mechanism from cycloid scales to ctenoid scales. As a result, it was possible to clarify one of the regulatory mechanisms of bone metabolism related genes in the formation of ctenoid scales.

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    • Regulatory mechanism of reproductive rhythms by male quail call stimulus that is different from the photoperiod.

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      UBUKA Takayoshi, HATTORI Atsuhiko

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      4 2011 - 3 2015

      Grant number：23570091

      Grant amount：\5980000 （ Direct Cost: \4600000 、 Indirect Cost：\1380000 ）

      This project aimed to reveal how the social environment regulates reproductive rhythms in the animal. The strongest factor that regulates reproductive rhythms is the photoperiod in photoperiodic animals in the temperate zone. However, because reproduction is a social activity in nature, reproductive activity is also influenced by social stimuli from males and females of the same species. In this project, we identified a gene that its expression level was significantly increased in the quail brain by male quail call stimulus for a long period under short day photoperiod. We further investigated the location of the gene product and found that it is expressed in neuronal clusters in the auditory nucleus in the quail brain. These results suggest that the male quail call stimulus is processed in these neurons in the auditory nucleus and transferred to gonadotropin-releasing hormone (GnRH) neurons and regulate luteinizing hormone (LH) secretion independent from the short day photoperiod.

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    • 魚鱗の再生と両生類変態期の後肢形成を骨形成モデルとしたメラトニンの制御機構の解明

      文部科学省/日本学術振興会 

      服部 淳彦, 田渕 圭章, 服部 淳彦

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      2012 - 2015

      Authorship：Principal investigator  Grant type：Competitive

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    • 魚鱗の再生と両生類変態期の後肢形成を骨形成モデルとしたメラトニンの制御機構の解明

      文部科学省/日本学術振興会 

      服部 淳彦, 田渕 圭章, 服部 淳彦

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      2012 - 2014

      Authorship：Principal investigator  Grant type：Competitive

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    • Development of the melatonin treatment which aimed at shortening of the recovery period after operation related bone tissue.

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      SATOMURA Kazuhito, TATEHARA Seiko, TOKUYAMA Reiko, YAMAMOTO Hideo, HATTORI Atsuhiko, TACHIBANA Ryusuke

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      2009 - 2011

      Grant number：21592575

      Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

      Melatonin, which is controlled by the light/dark cycle of the environment, promote growth and differentiation of osteoblasts. In this study, we elucidated that melatonin have the potential to promote the healing after bone fracture and osseointegration after dental implantation.

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    • Diurnal rhythm of the ridge formation in regenerating scale and its regulation by clock genes and melatonin

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      HATTORI Atsuhiko, SUZUKI Toru

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      2009 - 2011

      Grant number：21570062

      Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

      In the hard tissue the presence of the incremental line formed as a unit about a day has been known than before. The formation mechanism of the diurnal incremental line has not been clarified, then, in this study, the experiment was conducted to clarify the mechanism using a regenerating scale of the goldfish. In the expression of osteoblast-specific genes during spontaneous scale regeneration, it shared similarities in gene expression with mammalian intramembranous bone regeneration. The regenerating scales showed that the ridges(incremental lines) are formed in the outer one on each day. In the expression of clock genes in regenerating scale, a clear circadian rhythm was observed in the expression of per-3 gene. Improved understanding of the ridge formation in regenerating scale will help elucidate the mechanism of formation of the diurnal incremental line in the hard tissue.

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    • The relationship between the periodicity of incremental lines in the tooth dentin and a biological clock : Regulation by melatonin

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      MISHIMA Hiroyuki, TABATA J Makoto, SUZUKI Nobuo, HATTORI Atsuhiko

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      2008 - 2010

      Grant number：20592168

      Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

      It became clear that the melatonin receptors MT1 and MT2 were present in the tooth embryo. The level of melatonin concentration during the night time was higher than that of the daytime. The dark-staining layer of hematoxylin was observed at the calcification front of dentin formed during the night time. It is considered that calcification advances during night periods, when the dark-staining layer of hematoxylin is formed, while the light-staining layer is formed during the daytime. It is suggested that melatonin may participate in the periodicity of the incremental lines of dentin.

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    • Neuroendocrine basis of lunar-synchronized spawning migration in grass puffer

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      ANDO Hironori, HATTORI Atsuhiko

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      2008 - 2010

      Grant number：20570058

      Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

      To establish molecular basis of neuroendocrine control of lunar-synchronized spawning migration in grass puffer, we assessed changes in magnitudes of gene expression for various neurohormones and their receptors in the hypothalamus and pineal gland. In the hypothalamus, the expressions of those genes significantly increased during the spawning period and showed diurnal and circadian variations in association with changes in expression of melatonin receptor gene. In the pineal gland, melatonin receptor gene showed unique rhythmic expressions with 14 hours cyclicity and monthly variations. Observations of spawning behavior in spawning grounds and in aquarium revealed that the spawning rhythm is endogenously maintained possibly under the control of the circalunar clock in the pineal gland.

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    • 各種アミノ酸およびDNAメチル化に関与する食事因子とがん罹患に関するコホート研究

      日本学術振興会  科学研究費助成事業 

      永田 知里, 清水 弘之, 服部 淳彦

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      2008 - 2009

      Grant number：20014006

      Grant amount：\9400000 （ Direct Cost: \9400000 ）

      本研究は、各種アミノ酸やDNAメチル化に関与するメチオニン、葉酸、ビタミンB6、B12の食事からの摂取推定を可能とし、がん罹患との関連性を一般住民における前向き研究のデザインで評価することを目的としている。前年度では、岐阜県のがん登録および高山市医師会の飛騨がん登録より、高山市に1992年に開始されたコホート(高山コホート)内におけるがん罹患データを得たが、コホート内における死亡者、転居者の情報が把握出来ず、本年度、高山市での住民票閲覧、除票情報の提供、法務局への戸籍閲覧などを依頼した。未だ一部の情報が入手できておらず、また国の食品成分委員会による各食品中アミノ酸含有量改訂発表が遅れているが、まず、葉酸、ビタミンB6、B12摂取と大腸がんと乳がん罹患についての関連性を評価した。対象者は1992年9月前向き研究開始時にがん既往があると回答した者あるいはがん登録情報からこの時点でがんに罹患していたことが判明した者を除き、男性14,185名、女性16,560名であった。2005年末までの期間に新しく大腸がんと診断された者は男性277名、女性233名、乳がん罹患(女性のみ)は134名であった。年齢、喫煙歴、BMI、アルコール摂取量で補正後、男性におけるビタミンB12の上位1/3の高摂取群は下位1/3の低摂取群に比べ大腸がんハザード比が1.39と統計的に有意に高く(p=0.03)、またビタミンB6摂取も高摂取群はハザード比が1.37 (p=0.056)と高かった。しかし、これらの関連性は肉・肉加工品類摂取の補正により低下した。大腸がんリスクと葉酸摂取との関連性は認められなかった。女性では大腸がん、乳がんともこれらの栄養因子との関連は有意でなかった。多重共線性の問題に配慮しつつ、アミノ酸を含み、各栄養素、食品群の交絡の影響もさらに考慮する必要があると考えられる

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    • 迅速・高感度・簡便な新規骨粗鬆症モデル系の開発と予防法への応用

      日本学術振興会  科学研究費助成事業 

      北村 敬一郎, 根本 鉄, 服部 淳彦

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      2006 - 2008

      Grant number：18650197

      Grant amount：\2900000 （ Direct Cost: \2900000 ）

      [研究目的]魚類のウロコには骨形成をする骨芽細胞、骨吸収をする破骨細胞およびコラーゲンを中心とする骨基質タンパクからなり、健常骨モデル、骨代謝亢進モデルおよび骨吸収亢進モデル等の骨のモデルが作成できることを既に報告している。昨年は、これらの骨モデルに機械的刺激である低強度超音波を照射しその効果を調べた。その結果、健常骨モデルおよび骨代謝亢進モデルでは、骨形成が増加し、骨代謝亢進モデルでは、さらに骨吸収が抑制される効果も明らかとなった。一方、炎症性の骨吸収亢進モデルでは、骨形成および骨吸収作用に変化がないことが明らかとなった。今年度は、ウロコモデルで確認された低強度超音波の効果をマウスの頭蓋骨を使い、哺乳類の骨代謝に対する低強度超音波の効果を調べた。
      [研究成果]マウス新生仔をエーテル過剰吸入麻酔後、断頭し、頭蓋骨を取り出し左右を2等分した2骨片を対照群と曝露群とした。ウロコの系で決定した強度の低強度超音波を曝露群に照射後、対照群と同様に24時間組織培養し、超音波破砕し上清の酵素活性を測定した。その結果、骨形成をする骨芽細胞活性および骨吸収をする破骨細胞活性のどちらも変化しなかった。哺乳類の骨細胞は、骨基質内に存在しているため超音波が反射され届かないためと思われた。できるだけ骨組織が薄く柔らかいマウスの新生仔頭蓋骨を使ったが、細胞が表面にいるウロコとはやはり大きく異なることが明らかとなった。したがって、哺乳類の骨代謝を改善するためには、骨基質内にある細胞にも到達しうる機械的刺激が必要なことが示唆された。また、超音波の骨代謝への効果を調べるには、骨基質の表面に骨芽細胞と破骨細胞が共存するウロコが適したモデルとなることが明らかとなった。

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    • Cloning and expression of osteoclastic and osteoblastic markers in fish scale and the regulation of osteoclast differentiation by melatonin

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      HATTORI Atsuhiko

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      2006 - 2008

      Grant number：18570055

      Grant amount：\4000000 （ Direct Cost: \3400000 、 Indirect Cost：\600000 ）

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    • ホルモン合成と放出のバランス制御機構:単-LH細胞を用いた解析

      日本学術振興会  科学研究費助成事業 

      安東 宏徳, 服部 淳彦, 西村 正太郎

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      2006 - 2007

      Grant number：18570060

      Grant amount：\4050000 （ Direct Cost: \3600000 、 Indirect Cost：\450000 ）

      本研究の目的は,単一LH細胞を用いてLHの合成と放出のバランスをとる分子メカニズムを明らかにすることである。まず始めに,溶血プラークアッセイ法を用いてサクラマスの下垂体初代培養細胞から単一LH細胞を同定すると共に,LH放出活性の定量系を確立した。また,単一LH細胞のLH合成活性を測定するため,LHβサブユニットのmRNA定量系をリアルタイムPCR法を用いて確立した。最小検出感度は約100コピーであり,単一細胞中のLHβサブユニットmRNAの定量には十分の感度を持っていた。また,遺伝子の転写活性を測定する系として,ヘテロ核RNAを検出するリアルタイムPCR系を検討した。単一細胞のヘテロ核RNAの測定には最小検出感度に近いレベルでの精度のよい測定が必要であることが分かり,より精度よく安定して測定できるようにさらなる条件検討を行うことが必要である。
      サクラマスを非産卵期と産卵期前に採集し,単一LH細胞の合成と放出の解析系を用いて性成熟段階の異なる魚におけるバランス制御系の機能の違いを調べた。溶血プラークアッセイによって同定されたLH細胞の数は,非産卵期の魚は産卵期前の魚に比べて少なく,放出活性が低かった。また,リアルタイムPCR法によって測定したLHβサブユニットのmRNAも非産卵期では低かった。しかし,GnRHに対する反応性を調べると,非産卵期ではGnRH投与により放出と合成の活性が上昇したが,産卵期前では放出は高まったが合成は変化しなかった。産卵期前ではLHβサブユニット遺伝子の発現調節に関わる細胞内シグナル伝達系のGnRH応答性が変化することが示唆された。次に,ディファレンシャルディスプレイ法の一つであるGeneFishing法を用いて,両時期のLH細胞の間で発現量の異なる遺伝子の探索を行ったが,これまでのところ候補遺伝子は得られていない。使用した任意プライマーの数が少ないためと考えられる。

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    • 血清タンパク質の測定による野生鳥類の内分泌攪乱評価法の研究

      日本学術振興会  科学研究費助成事業 

      和田 勝, 奈良 雅之, 岡崎 三代, 服部 淳彦

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      2001 - 2003

      Grant number：13027220

      Grant amount：\14700000 （ Direct Cost: \14700000 ）

      野生鳥類における内分泌撹乱の現状を評価し、汚染との関係を明らかにする方法を確立するため、血中ビテロジェニンを指標にしてエストロジェン様攪乱を評価することにし、ウズラの血中ビテロジェニンを測定できるELISA系が確立した。これが野生鳥類に適用できるかを明らかにするため、キンカチョウを使ってデータを収集した。
      はじめに、キンカチョウの卵黄タンパク質をSDS-PAGEで泳動をしてウズラの卵黄タンパク質の泳動パターンと比較し、さらに、ウズラ卵黄リポビテリンを抗原としてウサギで作成したポリクローナル抗体との交叉を確認するために、ウエスターンブロッティング法で確認した。SDS-PAGEによる泳動パターンの比較とウエスターンブロッティングの結果は、キンカチョウ卵黄内に、ウズラと同じように120kDa付近に二本のバンドが抗体で認識された。
      キンカチョウ卵黄中にはウズラのリポビテリン抗体に交叉するリボビテリンが存在することが確認できたので、雄キンカチョウにエストラジオールを100g体重あたり0.1から公比10で1000ugまでの5段階の濃度でコーンオイル中に溶解し、7日間腹腔中に注射によって投与した。対照群はコーンオイルのみを投与した。7日間投与した後、血液を採取し、血清中のビテロジェニンをウズラビテロジェニンモノクローナル抗体によるELISAで測定し、血中エストラジオールも測定した。ビテロジェニン測定系の感度は検出限界0.0125ug/ml、エストラジオールは40pg/mlであった。血液採取後に、体重を測定し、肝臓、精巣の湿重量を測定した。体重はおよそ10gから15gなので、肝臓と精巣は10g体重あたりに換算した。上記の濃度を7日間投与したキンカチョウの肝臓の重量は群間で有意な差が認められず、精巣も1000ug投与群で減少傾向がみられたが、有意な差はなかった。エストラジオールの投与によって雄キンカチョウでも血中ビテロジェニン濃度が増加したが、0.1から10ugでは増加は認められなかった。血中のエストラジオールは1ug投与群で上昇しているが、血中ビテロジェニンの増加は認められなかった。
      ウズラではエストラジオール0.1ug投与で反応する個体が認められ、1ugではビテロジェニンの明らかな増加が認められるのに対して、キンカチョウではウズラに比べて明らかに反応性が低かった。ウズラのように離巣性で卵への投資量が大きな鳥類と、比較的卵への投資量が少ない就巣性の鳴禽類では、肝臓からのビテロジェニンの供給が異なることを示しているように思われた。野生鳥類での評価は、この点を考慮する必要があるだろう。

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    • Mechanism of spinal deformity produced by pinealectomy and the role of a circadian dock of the pineal gland on developing the spine in the chick

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      HATTORI Atsuhiko

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      2000 - 2002

      Grant number：12640647

      Grant amount：\3600000 （ Direct Cost: \3600000 ）

      Pinealectomized chickens ax known to develop scoliosis, but the mechanism underlying this phenomenon is unknown. On the other hand, the pineal gland at 1 day-old chick shows a ciicadian rhythm, however, the rhythm dumps out in accordance with aging. Therefore, we investigated the role of a arcadian dock in the pineal gland on the spinal deformity. We examined the rate of spinal deformity in the broilers that are pinealectomized at different ages. The rate of spinal deformity decreased in accordant with removal day of age. These results suggest that the Orcadian dock in the pineal gland is important to develop the spine. We conducted the next study to verify two proposed hypotheses lor the etiology of the spinal deformity: asymmetric growth cfliievertebral bone and the buckling. Tnerefore the influence of body growth on the degree of spinal deformity was investigated Piiiealectomized broilers at 1 day-old were kept under different dietary foods for 2 weeks. Tne mean degree of the spinal deformity in full, 75, and 50% diet was 50,38 and 13°, respectively. These residta show that the induction of spinal deformity in pinealectomized chicks is related to the body growth. Futhermore, the pinealectomized diiciks were sacrificed at 4 days old, and the 76 vertebra was collected and examined ossification in the anterior and posterior parts of the vertebral bone. No difference was found in ossification in the anterior part of vertebral bone, but the area of ossification in the posterior part was significantly larger (P<0.001) in the pinealectomized chicks. At present, scoliotic deformities were thought to occur as a result of causing differences in bone growth between the anterior and posterior elements of the vertebral column, and the buckling phenomenon caused by the marked increase of the body growth.

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    • Spinal deformity frequently produced by pinealectomy and the role of melatonin on developing the spine in chicks

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research 

      HATTORI Atsuhiko

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      1997 - 1998

      Grant number：09640788

      Grant amount：\3100000 （ Direct Cost: \3100000 ）

      The developing the spine is one of the most important process in all vertebrates. In our previous study the rate of deformity of the spine in pinealectomized layers was about 70% even though 2 months after pinealectomy. In the present study we examined the rate of spinal deformity in broilers by pinealectomy. The rate of spinal deformity in pinealectomized broilers at 8 day- and 15 day-old was 70 and 100% respectively, in which severe deformity at 15 day-old was 63%. Administration of melatonin in pinealectomized broilers significantly decreased the ratio and degree of spinal deformity. These results show the rate of the deformity of the spine in broilers was much higher than that of layers. Therefore, in the next step, the influence of body growth on the degree of spinal deformity was investigated. Pinealectomized broilers at 2 day-old were kept under dietary foods for 8 days ; full diet, 80% diet or 60% diet, respectively. The ratio of spinal deformity was not significant deferent among three dietary groups. These results show that the induction of spinal deformity in pinealectomized chicks is independent on the body growth. In the next study we examined whether the removal of the pineal gland changes bone minerals and plasma Ca concentrations. Calcium and phosphorus levels in the vertebra at 7 days after pinealectomy were significantly lower than those of controls, and on the other hand the plasma Ca concentrations significantly increased. Administration of 3-fold Ca on dietary food decreased the ratio and degree of spinal deformity. These results suggest that the pineal gland affects the bone metabolism in the process of developing chick spine.

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    • ホルモン遺伝子発現に関わるZnクラスタータンパク質・メタロチオネイン

      日本学術振興会  科学研究費助成事業 

      服部 淳彦

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      1995 - 1996

      Grant number：07804058

      Grant amount：\2200000 （ Direct Cost: \2200000 ）

      分化の基本骨格は,主としてある特定遺伝子の転写レベルの制御にある。この転写レベルの制御には,転写因子と呼ばれる一連のタンパク質が関与し,中でもステロイドホルモンのレセプターをはじめとする核内レセプターは,分子内にZnフィンガー構造をとる特徴的なタンパク質であり,金属であるZnが重要な役割を担っている。一方,メタロチオネイン(MT)は正常組織でもZnクラスタータンパク質として存在することが知られ,核内のレセプターとの間で何らかの機能関連が推測される。そこで,本研究では核内に出現するMTがいかなる働きをしているかを明らかにするために,正常ラット下垂体を用いて,各種ホルモン産生細胞とMTとの共存を免疫組織化学的手法および in situ hybridization法を用いて調べた。60日齢雄ラット1匹当たり5000〜9000個のGH細胞を調べたところ,0.44±0.15%の細胞の核においてMTが陽性であった。一方他のホルモン産生細胞においては,どの細胞もMTが共存している像は認められなかった。ラットGH産生細胞株であるMtT/Sに,E2,EGFおよびinsulinを複合作用させると,24時間目に急激にMTが発現し,それと時を同じくしてGHmRNA陽性細胞は有意に(p<0.01)減少し,PRLmRNA陽性細胞は有意に(p<0.01)増加することから,正常ラット下垂体における核内MT陽性GH細胞は、PRL細胞に変化する前段階の細胞である可能性が示唆された。現在胎仔期の下垂体GH細胞およびPRL細胞とMTとの関連を調べている。

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    • 下垂体前葉に新たに見いだされたメタロチオネインのホルモン遺伝子発現との関連

      日本学術振興会  科学研究費助成事業 

      服部 淳彦

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      1994 - 1994

      Grant number：06857004

      Grant amount：\900000 （ Direct Cost: \900000 ）

      メタロチオネインは,Znなどの重金属に結合する蛋白質であり,近年本蛋白質の核内における機能が注目されている。本研究では,ラット下垂体細胞株であるMtT/SにE2.INSおよびEGFを複合添加し,in situ hybridization法によるGHおよびPRLmRNA発現と免疫染色によるメタロチオネイン発現を経時的に比較した。
      メタロチオネインは,3種ホルモン添加後18時間まで対照群と同様にほとんど発現していなかったが,24時間目で急激に発現し(P<0.001).約40%の細胞が陽性像を示した。しかも,メタロチオネイン陽性細胞のうちの約80%において核のみにその存在が認められた。GHmRNA陽性細胞は3種ホルモン添加前には約60%に存在したが,添加後24時間から有意に(P<0.01)減少し,72時間では20%以下に減少した。一方,PRLmRNA陽性細胞は添加前にほとんど認められなかったが,添加後24時間から有意に(P<0.05)増加し,72時間には約5%の細胞が陽性像を示した。以上の結果は,核内に発現したメタロチオネインがホルモン遺伝子発現に関与する可能性を示唆するものである。

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    • メラトニンおよび食材に含まれるメラトニン様物質の抗酸化効果

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      Grant type：Competitive

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    • 骨代謝疾患における時間生物学的治療薬の開発

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      Grant type：Competitive

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    • 加齢性記憶障害とメラトニン

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      Grant type：Competitive

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    • 破骨・骨芽細胞の分化および機能解明－硬骨魚類のウロコを骨のモデルとして

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      Grant type：Competitive

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    • ホルモンの機能進化とそれを支える分子的基盤に関する研究

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      Grant type：Competitive

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    • Chronobiological study on developing the spine

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      Grant type：Competitive

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    • Study on the molecular aspects of evolution in the hormone and its function

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      Grant type：Competitive

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    • 骨芽細胞で作られるホルモンによる破骨細胞の調節機構：骨モデル（ウロコ）による解析

      文部科学省/日本学術振興会 

      鈴木 信雄, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 時刻情報伝達物質であるメラトニンによる象牙質の組織構造と象牙芽細胞の制御機構

      文部科学省/日本学術振興会 

      三島弘幸, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 学習記憶機能におけるメラトニンの抗加齢効果の解析

      文部科学省/日本学術振興会 

      千葉 篤彦, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 学習記憶機能におけるメラトニンの抗加齢効果に関する作用機序の解明

      文部科学省/日本学術振興会 

      千葉 篤彦, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • メラトニンと骨代謝調整ホルモン・サイトカインとの新規相互作用の解明

      文部科学省/日本学術振興会 

      池亀 美華, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 新規体内時計と環境因子によるクサフグの半月周性産卵リズムの形成機構

      文部科学省/日本学術振興会 

      安東 宏徳, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 食事由来のメラトニン：摂取量推定と閉経およびがん・循環器疾患との関連

      文部科学省/日本学術振興会 

      永田 知里, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 象牙質の成長線の周期と体内時計の情報伝達分子のメラトニンの分泌リズムとの関係

      文部科学省/日本学術振興会 

      三島 弘幸, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構の解明

      文部科学省/日本学術振興会 

      関口 俊男, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 白内障手術の全身的健康指標の改善効果

      文部科学省/日本学術振興会 

      綾木 雅彦, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 骨組織におけるメラトニンと機械的刺激の相互作用の解明

      文部科学省/日本学術振興会 

      池亀 美華, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構 の解明

      文部科学省/日本学術振興会 

      関口 俊男, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • 新規硬組織モデルを用いた微小重力・過重力下での骨吸収及び骨形成の機構解析

      文部科学省/日本学術振興会 

      鈴木 信雄, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    • メラトニンと骨代謝調節ホルモン・サイトカインとの新規相互作用の解明

      文部科学省/日本学術振興会 

      池亀 美華, 服部 淳彦

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      Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

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    Industrial property rights

    • LONG-TERM MEMORY INDUCING AGENT

      HATTORI, Atsuhiko, MATSUMOTO, Yukihisa, KAGECHIKA, Hiroyuki, MASUNO, Hiroyuki

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      Applicant：NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , SOPHIA SCHOOL CORPORATION

      Application no：15/593,571  Date applied：12 5 2017

      Announcement no：2018-0327348-A1  Date announced：15 11 2018

      Patent/Registration no：特許US10266482  Date registered：23 4 2019 

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    • 胎盤抽出物の製造方法

      服部 淳彦, 丸山 雄介, 宮内 大治, 横川 剛, 高野 裕二朗

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      Applicant：国立大学法人東京医科歯科大学、株式会社協和

      Application no：特願2015-234222  Date applied：30 11 2015

      Announcement no：特開2017-10097  Date announced：8 6 2017

      Patent/Registration no：特許第6769705号 

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    • 長期記憶誘導剤

      服部 淳彦, 松本 幸久, 影近 弘之, 増野 弘幸, 千葉 篤彦, 岩下 洸

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      Applicant：国立大学法人東京医科歯科大学、学校法人上智学院

      Application no：特願2016-042875  Date applied：4 3 2016

      Announcement no：特開2016-166197  Date announced：15 9 2016

      Patent/Registration no：特許第6836044号 

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    Social Contribution

    • 老化スイッチ：体内時計の乱れが老化を加速する！

      Media coverage

      日本経済新聞社  日経Gooday  5 1 2018

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      Audience： Media

      Type：Newspaper, magazine

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    • ノーベル賞で注目の体内時計、リズムを作るメラトニンを受け取る受容体と呼ばれるたんぱく質

      Media coverage

      日本経済新聞社  日経Gooday  5 12 2017

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      Audience： Media

      Type：Newspaper, magazine

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    • 私たちの体・心・肌は１日のリズムで変化しています

      Informant

      文化出版局  ミセス  7 8 2017

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      Audience： General

      Type：Promotional material

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    • １日のリズムを意識する「時間美容」のすすめ

      Media coverage,　Informant

      小学館  美的  23 3 2017

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      Audience： General

      Type：Promotional material

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    Other

    • Melatonin: finally, a supplement that actually boosts memory

      12 2020
      -
      12 2020

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    • 「 メラトニンの代謝産物AMKが長期記憶を促進する 」― 加齢に伴う記憶力低下の改善に期待 ―

      11 2020
      -
      11 2020

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      Journal of Pineal research

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    • 宇宙空間で引き起こされる骨吸収がメラトニンによって抑制！

      7 2019
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      7 2019

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      Journal of Pineal Research

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