Updated on 2024/05/23

写真b

 
ZHANG Yiting
 
*Items subject to periodic update by Rikkyo University (The rest are reprinted from information registered on researchmap.)
Affiliation*
College of Science Department of Chemistry
Title*
Assistant Professor
Research Interests
  • Sentinel lymph node

  • Near-infrared fluorescence imaging

  • Drug biodistribution

  • Drug delivery systems

  • Cancer treatment

  • Microfluidics device

  • コロイド化学

  • Campus Career*
    • 4 2023 - Present 
      College of Science   Department of Chemistry   Assistant Professor
     

    Research Areas

    • Life Science / Tumor diagnostics and therapeutics

    • Nanotechnology/Materials / Nano/micro-systems

    Research History

    • 4 2023 - Present 
      Rikkyo University   Department of Chemistry, College of Science   Assistant Professor

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      Country:Japan

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    • 4 2021 - 3 2023 
      The University of Tokyo   Graduate School of Arts and Sciences Basic Science,Section of Multi-Disciplinary Sciences,

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      Country:Japan

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    • 4 2018 - 3 2021 
      Japan Society for the Promotion of Science   DC1

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      Country:Japan

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    Education

    • 4 2017 - 3 2021 
      Chiba University   Graduate School of Medical and Pharmaceutical Sciences   Frontier of Medical and Pharmaceutical Sciences

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      Country: Japan

      Notes: Doctor degree course

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    • 4 2015 - 3 2017 
      Chiba University   Graduate School of Engineering   Artificial System Science

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      Country: Japan

      Notes: Master degree program

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    • 4 2011 - 3 2015 
      Chiba University   Faculty of Engineering   Department of Medical System Engineering

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      Country: Japan

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    • 4 2007 - 3 2010 
      群馬県立前橋高等学校

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      Country: Japan

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    Papers

    • A Practical Guide to Preparation and Applications of Giant Unilamellar Vesicles Formed via Centrifugation of Water-in-Oil Emulsion Droplets Peer-reviewed

      Yiting Zhang, Haruto Obuchi, Taro Toyota

      Membranes13 ( 4 ) 440 - 440   18 4 2023

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      Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

      Giant vesicles (GVs), which are closed lipid bilayer membranes with a diameter of more than 1 μm, have attracted attention not only as model cell membranes but also for the construction of artificial cells. For encapsulating water-soluble materials and/or water-dispersible particles or functionalizing membrane proteins and/or other synthesized amphiphiles, giant unilamellar vesicles (GUVs) have been applied in various fields, such as supramolecular chemistry, soft matter physics, life sciences, and bioengineering. In this review, we focus on a preparation technique for GUVs that encapsulate water-soluble materials and/or water-dispersible particles. It is based on the centrifugation of a water-in-oil emulsion layered on water and does not require special equipment other than a centrifuge, which makes it the first choice for laboratory use. Furthermore, we review recent studies on GUV-based artificial cells prepared using this technique and discuss their future applications.

      DOI: 10.3390/membranes13040440

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    • [Original] Release of liposomally formulated infrared fluorescent probes included in giant cluster vesicles by ultrasound irradiation Peer-reviewed

      K. Seo, Y. Zhang, T. Toyota, H. Hayashi, S. Hirata, T. Yamaguchi, K. Yoshida

      Ultrasonics134   107102   2023

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      Publishing type:Research paper (scientific journal)  

      Detection of tumors and regional lymph nodes during surgery has been proposed in the diagnosis of lymphatic metastasis and the surgical treatment of malignant diseases. Giant cluster vesicles (GCVs), including liposomally formulated indocyanine green (LP-ICG) derivatives, are a possible candidate for agents to realize the two contradictory properties, i.e., retention in tissue for lesion-marking and trace for sentinel lymph nodes (SLNs) identification. We attempted to release the LP-ICG derivatives from GCVs using ultrasound contrast agents (UCAs) under ultrasound irradiation. An absorption spectrophotometer quantitatively evaluated the amounts of released LP-ICG derivatives. As a result, we demonstrated that it depended on conditions for sound pressure, burst length, and number density of UCAs, and had a sound pressure threshold independent of burst length and number density of UCAs. The results will aid to determine appropriate conditions to maximize the released amount of LP-ICG derivatives while keeping safety.

      DOI: 10.1016/j.ultras.2023.107102

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    • Stannous colloid mixed with indocyanine green as a tracer for sentinel lymph node navigation surgery Peer-reviewed

      Yiting Zhang, Tomoya Uehara, Taro Toyota, Ryusuke Endo, Hisahiro Matsubara, Hideki Hayashi

      Scientific Reports12 ( 1 )   12 10 2022

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      Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

      Abstract

      The combined use of a vital dye and radioactive colloid reportedly performs better in detecting sentinel lymph nodes (SLNs) for cancers than the use of either of them alone. However, especially for gastric cancer, two endoscopic procedures are required to administer these two tracers, which burdens the patients and practitioners. Here we propose the use of stannous colloid (SnC) mixed with indocyanine green (ICG) as a new mixed tracer (SnC–ICG); its characteristics were investigated in vivo and in vitro to estimate its usefulness for SLN navigation. The tracers were administered to rats and the accumulation of radioactivity and/or near-infrared fluorescence were evaluated in the regional lymph nodes (LNs) using single positron emission computed tomography and near-infrared fluorescence imaging, respectively. SnC–ICG showed significantly better clearance from the injection site and better migration to primary LNs than the single administration of SnC or ICG aqueous solution. SnC–ICG demonstrated a wide particle size variability, stabilized to 1200-nm upon the addition of albumin in vitro; These properties could contribute to its behavior in vivo. The use of SnC–ICG could contribute better performance to detect SLNs for gastric cancer with less burden on both patients and medical practitioners.

      DOI: 10.1038/s41598-022-21420-z

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      Other Link: https://www.nature.com/articles/s41598-022-21420-z

    • Identifying and Manipulating Giant Vesicles: Review of Recent Approaches Invited Peer-reviewed

      Taro Toyota, Yiting Zhang

      Micromachines13 ( 5 ) 644 - 644   19 4 2022

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

      Giant vesicles (GVs) are closed bilayer membranes that primarily comprise amphiphiles with diameters of more than 1 μm. Compared with regular vesicles (several tens of nanometers in size), GVs are of greater scientific interest as model cell membranes and protocells because of their structure and size, which are similar to those of biological systems. Biopolymers and nano-/microparticles can be encapsulated in GVs at high concentrations, and their application as artificial cell bodies has piqued interest. It is essential to develop methods for investigating and manipulating the properties of GVs toward engineering applications. In this review, we discuss current improvements in microscopy, micromanipulation, and microfabrication technologies for progress in GV identification and engineering tools. Combined with the advancement of GV preparation technologies, these technological advancements can aid the development of artificial cell systems such as alternative tissues and GV-based chemical signal processing systems.

      DOI: 10.3390/mi13050644

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    • Effect of an Oil Medium on Giant Vesicles Prepared with Water-in-Oil Emulsion

      Taro Toyota, Yiting Zhang

        71 ( 1・2 ) 83 - 89   1 2022

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      Language:Japanese  

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    • Fluorescence intensity changes depending on viscoelasticity of lipid shell coating microbubbles labeled with an indocyanine green derivative Peer-reviewed

      K. Yoshida, M. Ebata, C. Kaneko, Y. Zhang, Y. Shibata, K. Saito, T. Toyota, H. Hayashi, T. Yamaguchi

      JAPANESE JOURNAL OF APPLIED PHYSICS60 ( SD )   7 2021

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOP PUBLISHING LTD  

      Lipid-coated microbubbles (MBs) with an indocyanine green (ICG) derivative were fabricated for ultrasound and near-infrared (NIR) fluorescence dual imaging. We characterized the NIR-fluorescence intensity, stability and viscoelastic properties of the encapsulating lipid shell, focusing on the influence of the ICG derivative and lipid compositions. In terms of the NIR fluorescence intensity, the fluorescence intensity of the MBs (with the ICG derivative) was significantly affected by the lipid composition of the MB shell. Regarding the contrast agent used for ultrasound imaging, the stability of the MBs and viscoelastic properties of shell also depended on the lipid compositions, while the incorporation of the ICG derivative into the MB shells had a negligible effect. The performance of this contrast agent for ultrasound and NIR fluorescence dual-imaging exhibited a significant trade-off relationship for the lipid composition.

      DOI: 10.35848/1347-4065/abf2ab

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    • The Use of Giant Vesicles for Medical Applications: A Trend in the Last Decade Peer-reviewed

      Taro Toyota, Yiting Zhang, Hideki Hayashi

      Sensors and Materials33 ( 1 ) 261 - 261   22 1 2021

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:MYU K.K.  

      DOI: 10.18494/sam.2021.3072

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    • Biodistribution of liposomes in the lymphatics according to particle size Peer-reviewed

      Yiting Zhang, Taro Toyota, Hisahiro Matsubara, Hideki Hayashi

      Japanese Journal of Lymphology40 ( 1 ) 23 - 30   6 2017

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      Authorship:Lead author   Language:English   Publisher:日本リンパ学会  

      粒子径200、400、800nmの近赤外(NIR)蛍光リポソームを用いて、生体内分布を調べた。ラットモデルにおける組織学的分析から、リポソームの粒子径が増加するに従って、一次リンパ節における分布度が低下していた。粒子径400nmのリポソーム製剤はブタモデルにおいて、粒子は胃から一次リンパ節に留まっていた。この粒子径は先行研究でSLNの検出に使用されたトレーサーの最適サイズよりも大きかった。NIR蛍光画像でSLNを効率よく検出するには、リポソームの粒子径を調整することが重要であると考えられた。

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    • [Proceeding] Destruction of giant cluster-like vesicles assisted by contrast agent under 2.8 MHz ultrasound Peer-reviewed

      K. Yoshida, R. Yahagi, Y. Zhang, M. Ebata, T. Toyota, T. Yamaguchi, H. Hayashi

      IEEE Int. Ultrason. Symp. IUS   4   2017

    • Destruction of giant cluster-like vesicles by an ultrasonically activated device Peer-reviewed

      Ryosuke Yahagi, Kenji Yoshida, Yiting Zhang, Masahiko Ebata, Taro Toyota, Tadashi Yamaguchi, Hideki Hayashi

      JAPANESE JOURNAL OF APPLIED PHYSICS55 ( 7 )   7 2016

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOP PUBLISHING LTD  

      In this paper, we propose a technically simple method of destroying a tissue marker composed of giant cluster-like vesicles (GCVs) to facilitate laparoscopic surgeries; the method releases various biological tracers contained in GCVs. An ultrasonically activated device (USAD) emitting 55.5 kHz ultrasound was employed for this purpose. Optical microscopy and fluorospectrophotometry revealed the destruction of GCVs after ultrasound irradiation when the blade tip was set 1.0 mm or closer to, but not directly in contact with, a GCV-containing cell. This means that USAD could be safely used for destroying this GCV tissue marker in clinical settings. (C) 2016 The Japan Society of Applied Physics

      DOI: 10.7567/JJAP.55.07KF21

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    Books and Other Publications

    • エマルションの安定化のための新しい調製技術と評価

      章 逸汀, 小淵 晴仁, 吉田 憲司, 林 秀樹, 豊田 太郎( Role: Contributor ,  第5章 医薬品におけるエマルションの調製と安定化、3節 油中水滴エマルションで作製した機能化ジャイアントベシクルのバイオ応用)

      技術情報協会  31 10 2022  ( ISBN:9784861049002

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    • Molecular Robotics: An Introduction

      T. Toyota, Y. Zhang( Role: Contributor ,  7.2 Giant Vesicle Application Linked to Biological Systems, pp.258-267)

      Springer Nature Singapore Pte Ltd (S. Murata ed.)  8 2022  ( ISBN:9789811939860

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    Presentations

    • マイクロ流体デバイス内に捕捉されたコレステロール含有/未含有 ジャイアントベシクルのßシクロデキストリン誘導体応答

      章逸汀, 小淵晴仁, 濵田省吾, 杉山博紀, 村田智, 豊田太郎

      化学とマイクロ・ナノシステム学会 第47回研究会  13 5 2023 

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      Event date: 13 5 2023 - 14 5 2023

      Language:Japanese   Presentation type:Poster presentation  

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    • Construction of a microfluidic device for the triad formation of uniformly sized liposomes

      Yiting Zhang, Shogo Hamada, Yuktesh Balaji, Hironori Sugiyama, Satoshi Murata, Taro Toyota

      International Workshop on Molecular Cybernetics: Toward Chemical AI  14 3 2022 

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      Event date: 14 3 2022 - 15 3 2022

      Language:English   Presentation type:Poster presentation  

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    • インドシアニングリーンを配合したスズコロイド製剤のリンパ動態に関する検討 Invited

      章 逸汀

      日本蛍光ガイド手術研究会 第4回学術集会  14 5 2021 

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      Event date: 14 5 2021 - 15 5 2021

      Language:Japanese   Presentation type:Oral presentation (general)  

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    • センチネルリンパ節ナビゲーションのためのICGを組み込んだ錫コロイドの基礎解析(Fundamental analysis of tin colloid incorporated with ICG for sentinel lymph node navigation)

      Zhang Yiting, Kano Masayuki, Matsubara Hisahiro, Hayashi Hideki

      日本内視鏡外科学会雑誌  3 2021  (一社)日本内視鏡外科学会

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      Event date: 3 2021 - 3 2021

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    • Experimental evaluation of viscoelastic properties of phospholipid membrane coating lipid bubbles

      金兒千晶, 章逸汀, 豊田太郎, 林秀樹, 山口匡, 吉田憲司

      日本音響学会研究発表会講演論文集(CD-ROM)  2021 

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      Event date: 2021 - 2021

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    • Fundamental study on controlled release of tracer particles contained in giant cluster vesicles

      瀬尾康太, 章逸汀, 豊田太郎, 林秀樹, 山口匡, 吉田憲司

      日本音響学会研究発表会講演論文集(CD-ROM)  2021 

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      Event date: 2021 - 2021

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    • Experimental Investigation of the Stability of Contrast Agents for Ultrasound and Near Infrared Fluorescence dual imaging

      金兒千晶, 章逸汀, 豊田太郎, 林秀樹, 山口匡, 吉田憲司

      超音波医学 Supplement  2021 

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      Event date: 2021 - 2021

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    • インドシアニングリーンを配合したスズコロイド製剤の物理特性に関する検討 Invited

      章 逸汀

      日本蛍光ガイド手術研究会 第3回学術集会  16 10 2020 

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      Event date: 16 10 2020 - 17 10 2020

      Language:Japanese   Presentation type:Oral presentation (general)  

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    • 非特異的免疫賦活剤を用いた光免疫療法に関する基礎的検討

      章 逸汀, 林 秀樹

      千葉医学雑誌  8 2020  千葉医学会

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      Event date: 8 2020 - 8 2020

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    • 胃癌に対する色素法・RI法併用センチネルリンパ節ナビゲーションの至適トレーサー調整法の検討

      章 逸汀, 加野 将之, 松原 久裕, 林 秀樹

      日本内視鏡外科学会雑誌  12 2019  (一社)日本内視鏡外科学会

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      Event date: 12 2019 - 12 2019

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    • Fundamental analysis of Near-infrared and Ultrasound hibrid contrast agents targeting the Sentinel lymph node

      Yiting Zhang, Kenji Yoshida, Tadashi Yamaguchi, Hideki Hayashi

      28 11 2019 

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      Event date: 28 11 2019 - 28 11 2019

      Language:English   Presentation type:Poster presentation  

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    • Development of multimodal nanocarrier for sentinel lymph node mapping and cancer immunotherapy agents

      Yiting Zhang, Hideki Hayashi

      Fourth International Symposium on Multimodal Medical Engineering  30 8 2019 

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      Event date: 30 8 2019 - 30 8 2019

      Language:English   Presentation type:Oral presentation (general)  

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    • 悪性疾患に対する光免疫療法を用いた基礎検討

      章 逸汀, 林 秀樹

      第17回千葉大学医工学シンポジウム  2019 

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      Event date: 2019 - 2019

      Language:Japanese   Presentation type:Poster presentation  

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    • Development of an anti-tumor immunotherapy exploiting sentinel lymph node environment Invited

      Yiting Zhang, Taro Toyota, Yuki Tange, Hisahiro Matsubara, Hideki Hayashi

      SHOUTH AFRICA-JAPAN Bilateral Symposium 2018  24 10 2018 

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      Event date: 22 10 2018 - 26 10 2018

      Language:English   Presentation type:Oral presentation (invited, special)  

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    • Analysis of lymphatic biodistribution of liposomes with the use of a hydrophobic form of indocyanine green derivative

      Yiting Zhang, Taro Toyota, Yuki Tange, Hisahiro Matsubara, Hideki Hayashi

      International Sentinel Node Society Biennial Meeting 2018 (ISNS2018)  11 10 2018 

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      Event date: 11 10 2018 - 13 10 2018

      Language:English   Presentation type:Oral presentation (general)  

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    • Destruction of Giant Cluster-Like Vesicles Assisted by Contrast Agent under 2.8 MHz Ultrasound Irradiation

      K. Yoshida, T. Yamaguchi, H. Hayashi, R. Yahagi, Y. Zhang, M. Ebata, T. Toyota

      2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)  2017  IEEE

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      Event date: 2017 - 2017

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      Giant cluster-like vesicles (GCVs) encapsulating near-infrared fluorescent liposomes and X-ray contrast agents coated with lipids can play a multifunctional role, e.g. preoperatively and intraoperatively localizing tumors and reservoir of a fluorescent tracer for detecting sentinel lymph nodes if they are destroyed. We propose the method to assess the destruction of GCVs using the interaction between the ultrasound (US) and ultrasound contrast agents (UCAs). The GCVs were exposed to 2.8 MHz ultrasound with commercial UCA solution. The negative peak pressure of ultrasound was 0, 0.06, 0.56, 1.1 and 1.6 MPa. The measurements of radii of GCVs was conducted after ultrasound exposure. The result demonstrated that bigger GCVs are split to become many smaller GVs. The results indicated that the interaction between US and UCA enhances the destruction of bigger GCVs and increased the amount of smaller GCVs.

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    • リポソームの粒子径とリンパ節滞留性に関する検討

      章逸汀

      第40回日本リンパ学会総会  24 6 2016 

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      Event date: 24 6 2016 - 25 6 2016

      Language:Japanese   Presentation type:Poster presentation  

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    • 1P5-13 Destruction of tissue marker for gastrointestinal tumor localization by ultrasound irradiation

      Yahagi Ryosuke, Yosida Kenzi, Zhang Yiting, Ebata Masahiko, Toyota Taro, Yamaguchi Tadashi, Hayashi Hideki

      Proceedings of Symposium on Ultrasonic Electronics  5 11 2015  Steering committee of symposium on ultrasonic electronics

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      Event date: 5 11 2015 - 5 11 2015

      Language:English  

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    • 各種エネルギーデバイスのピットフォールと適切な使用方法 腹腔鏡下胃癌手術後の膵液瘻 超音波凝固切開装置の関与について

      林 秀樹, 高 涛, 大友 修平, 矢作 亮介, 章 逸汀, 山口 匡, 羽成 直行, 郡司 久, 加野 将之, 早野 康一, 松原 久裕

      日本臨床外科学会雑誌  10 2015  日本臨床外科学会

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      Event date: 10 2015 - 10 2015

      Language:Japanese  

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    • 疎水性インドシアニングリーン誘導体のセンチネルリンパ節同定における有用性の検討

      章 逸汀, 矢作亮介, 大友修平, 高 涛, Lau Bik Ee, 豊田太郎, 林 秀樹, 松原久裕

      第7回蛍光Navigation Surgery研究会  18 10 2014 

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      Event date: 18 10 2014 - 18 10 2014

      Language:Japanese   Presentation type:Oral presentation (general)  

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    Professional Memberships

    • 9 2023 - Present 
      The Japan Society for Analytical Chemistry

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    • 4 2023 - Present 
      Society for Chemistry and Micro-Nano Systems

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    • 7 2019 - Present 
      日本内視鏡外科学会

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    • 9 2016 - Present 
      日本リンパ学会

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    Research Projects

    • Fundamental study on a new photo dynamic immunotherapy of cancers based on the sentinel lymph nodes theory

      Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows 

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      4 2018 - 3 2021

      Grant number:18J21091

      Grant amount:\1200000 ( Direct Cost: \1200000 )

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