Updated on 2021/06/22

写真b

 
ISHIWATA Takayuki
 
*Items subject to periodic update by Rikkyo University (The rest are reprinted from information registered on researchmap.)
Affiliation*
College of Community and Human Services Department of Sport and Wellness
Graduate School of Community and Human Services Field of Study: Community and Human Services
Graduate School of Community and Human Services Field of Study: Community and Human Services
Title*
Professor
Degree
修士(教育学) ( 横浜国立大学 ) / 博士(理学) ( 東京都立大学 ) / Doctor of Science ( Tokyo Metropolitan University ) / Master of Education ( Yokohama National University )
Contact information
Mail Address
Research Theme*
  • 環境生理学、温熱生理学を専門分野とし、体温調節におけるセロトニンやモノアミンなどの脳内神経伝達物質の役割について研究を行っている。また、私達を取り巻く生活環境の変化や生活習慣の乱れから生じる生体の様々な問題について、生理学的・神経科学的観点から物事を捉え、解決策を考えている。最近ではメンタルヘルスに注目した、小学生の体組成や運動との関係についての生理心理学的検討も行っている。

  • Research Interests
  • 睡眠

  • Sleep regulation

  • Physiology

  • Neurotransmitter

  • Thermoregulation

  • Campus Career*
    • 4 2018 - Present 
      College of Community and Human Services   Department of Sport and Wellness   Professor
    • 4 2018 - Present 
      Graduate School of Community and Human Services   Field of Study: Community and Human Services   Professor
    • 4 2018 - Present 
      Graduate School of Community and Human Services   Field of Study: Community and Human Services   Professor
    • 4 2010 - 3 2018 
      College of Community and Human Services   Department of Sport and Wellness   Associate Professor
    • 4 2008 - 3 2010 
      College of Community and Human Services   Department of Sport and Wellness   Assistant Professor
     

    Research Areas

    • Life Science / Physiology

    • Life Science / Sports sciences  / Thermoregulation

    Research History

    • 4 2018 - Present 
      RIKKYO UNIVERSITY   Graduate School of Community and Human Services Field of Study: Community and Human Services   Professor

      More details

    • 4 2018 - Present 
      RIKKYO UNIVERSITY   College of Community and Human Services Department of Sport and Wellness   Professor

      More details

    • 4 2018 - Present 
      RIKKYO UNIVERSITY   Graduate School of Community and Human Services Field of Study: Community and Human Services   Professor

      More details

    • 4 2006 - Present 
      Meiji University   School of Political Science and Economics

      More details

    • 4 2010 - 3 2018 
      RIKKYO UNIVERSITY   College of Community and Human Services Department of Sport and Wellness   Associate Professor

      More details

    • 4 2008 - 3 2010 
      RIKKYO UNIVERSITY   College of Community and Human Services Department of Sport and Wellness   Assistant Professor

      More details

    • 4 2006 - 3 2010 
      東京都老人総合研究所   協力研究員

      More details

    • 4 2006 - 3 2008 
      Tokyo University of Social Welfare   School of Social Welfare

      More details

    • 4 2006 - 3 2008 
      Tokyo University of Social Welfare, Junior College   Tokyo University of Social Welfare, Junior College

      More details

    • 4 2005 - 3 2006 
      Seikei University   Faculty of Economics

      More details

    • 4 2004 - 3 2006 
      横浜国立大学 教育人間科学部   非常勤講師

      More details

    • 4 2004 - 3 2006 
      横浜国立大学 教育人間科学部   非常勤講師

      More details

    • 4 2003 - 3 2006 
      株式会社ダイキン環境研究所   エキスパート契約研究員

      More details

    • 4 2003 - 3 2004 
      Toho University   Faculty of Medicine

      More details

    • 10 2002 - 3 2003 
      Tokyo Metropolitan University.   Graduate School of Science

      More details

    • 4 2002 - 9 2002 
      小田原高等看護専門学校   非常勤講師

      More details

    • 4 1998 - 3 2002 
      学校法人聖学院 聖学院中学校高等学校   非常勤講師

      More details

    • 4 1997 - 3 1999 
      横浜国立大学 教育人間科学部   ティーチングアシスタント

      More details

    • 4 1997 - 3 1999 
      横浜国立大学 教育人間科学部   ティーチングアシスタント

      More details

    ▼display all

    Education

    • - 9 2002 
      Tokyo Metropolitan University   Graduate School, Division of Natural Science

      More details

      Country: Japan

      researchmap

    • - 3 1999 
      Yokohama National University   Graduate School, Division of Education

      More details

      Country: Japan

      researchmap

    • - 3 1997 
      Yokohama National University   Faculty of Education

      More details

      Country: Japan

      researchmap

    Committee Memberships

    • 4 2015 - Present 
      日本生理学会   評議員

      More details

      Committee type:Academic society

      researchmap

    • 4 2014 - Present 
      日本体力医学会   評議員

      More details

      Committee type:Academic society

      researchmap

    Papers

    • Effect of short- and long-term heat exposure on brain monoamines and emotional behavior in mice and rats Peer-reviewed

      Hikaru Nakagawa, Takayuki Ishiwata

      Journal of Thermal Biology99   102923   28 3 2021

      More details

      Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

      DOI: 10.1016/j.jtherbio.2021.102923

      researchmap

    • Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats Peer-reviewed

      Daisuke Matsunaga, Hikaru Nakagawa, Takayuki Ishiwata

      Neuroscience Letters744   135556   23 1 2021

      More details

      Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Comparison of neurotransmitter levels, physiological conditions, and emotional behavior between isolation-housed rats with group-housed rats, Develomental Psychobiology Peer-reviewed

      Yuta Kaneda, Akira Kawata, Kota Suzuki, Daisuke Matsunaga, Mikinobu Yasumatsu, Takayuki Ishiwata

      Develomental Psychobiology63   452 - 460   25 8 2020

      More details

      Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

      DOI: 10.1002/dev.22036

      researchmap

    • Effect of heat acclimation on anxiety-like behavior of rats in an open field Peer-reviewed

      Hikaru Nakagawa, Daisuke Matsunaga, Takayuki Ishiwata

      Journal of Thermal Biology87   102458   12 2019

      More details

      Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus Peer-reviewed

      Takayuki Ishiwata, Benjamin N. Greenwood

      Journal of Comparative Physiology B188   541 - 551   2 2018

      More details

      Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer  

      researchmap

    • Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats Peer-reviewed

      Takayuki Ishiwata, Hiroshi Hasegawa, Benjamin N. Greenwood

      Neuroscience Letters653   71 - 77   5 2017

      More details

      Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior Peer-reviewed

      Brian A. Lloyd, Holly S. Hake, Takayuki Ishiwata, Caroline E. Farmer, Esteban C. Loetz, Monika R. Fleshner, Sondra T. Bland, Benjamin N. Greenwood

      Behavioural Brain research323   56 - 67   1 2017

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier  

      researchmap

    • Possible mechanisms of hypothermia after inhibition of the median or dorsal raphe nucleus of freely moving rats. Peer-reviewed

      Ishiwata T, Oshimoto A, Saito T, Kotani Y, Nomoto S, Aihara Y, Hasegawa H, Greenwood BN

      NeuroReport27   1287 - 1292   10 2016

      More details

      Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • The effects of resilience on subjective stress response and salivary secretory immunoglobulin A in university students Peer-reviewed

      Hisashi Mitsuishi, Shintaro Endo, Takayuki Ishiwata, Kazuo Oishi

      Journal of Physical Fitness and Sports Medicine5 ( 4 ) 319 - 327   9 2016

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Changes of brain monoamine levels and physiological indexes during heat acclimation in rats Peer-reviewed

      Hikaru Nakagawa, Takeru Matsumura, Kota Suzuki, Chisa Ninomiya, Takayuki Ishiwata

      Journal of Thermal Biology58   15 - 22   4 2016

      More details

      Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier  

      researchmap

    • Source analysis of stimulus-preceding negativity constrained by functional magnetic resonance imaging Peer-reviewed

      Yasunori Kotani, Yoshimi Ohgami, Takayuki Ishiwata, Jun-ichiro Arai, Shigeru Kiryu, Yusuke Inoue

      Biological Psychology111   53 - 64   9 2015

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • 唾液アミラーゼを用いた大学体育実技のメンタルヘルス改善効果の評価 Peer-reviewed

      柳田信也, 久保田夏子, 石渡貴之

      大学体育学12   66 - 82   4 2015

      More details

      Language:Japanese   Publishing type:Research paper (scientific journal)  

      researchmap

    • Influence of circadian disruption on neurotransmitter levels, physiological indexes, and behaviour in rats Peer-reviewed

      Takeru Matsumura, Hikaru Nakagawa, Kota Suzuki, Chisa Ninomiya, Takayuki Ishiwata

      CHRONOBIOLOGY INTERNATIONAL32 ( 10 ) 1449 - 1457   2015

      More details

      Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:TAYLOR & FRANCIS INC  

      Brain monoamines-such as noradrenaline (NA), dopamine (DA) and serotonin (5-HT)-regulate several important physiological functions, including the circadian rhythm. The purpose of this study was to examine changes in NA, DA and 5-HT levels in various brain regions and their effect on core body temperature (T-c), heart rate (HR) and locomotor activity (Act) in rats following exposure to an artificial light/dark (LD) cycle. For this, male Wistar rats were housed at an ambient temperature (T-a) of 23 degrees C and 50% relative humidity with free access to food and water. Rats were exposed to either natural (12 h: 12 h) or artificial (6 h: 6 h) LD cycles for 1 month, after which each brain region was immediately extracted and homogenized to quantify the amounts of NA, DA and 5-HT by high-performance liquid chromatography. Behavioural changes were also monitored by the ambulatory activity test (AAT). Notably, we found that artificial LD cycles disrupted the physiological circadian rhythms of T-c, HR and Act. Although the 5-HT levels of rats with a disrupted circadian rhythm decreased in cell bodies (dorsal and median raphe nuclei) and projection areas (frontal cortex, caudate putamen, preoptic area and suprachiasmatic nucleus) relative to the control group, NA levels increased both in the cell body (locus coeruleus) and projection area (paraventricular hypothalamus). No significant changes were found with respect to DA. Moreover, circadian rhythm-disrupted rats also showed anxious behaviours in AAT. Collectively, the results of this study suggest that the serotonergic and noradrenergic systems, but not the dopaminergic system, are affected by artificial LD cycles in brain regions that control several neural and physiological functions, including the regulation of physiological circadian rhythms, stress responses and behaviour.

      DOI: 10.3109/07420528.2015.1105250

      researchmap

    • Role of serotonergic system in thermoregulation in rats. Invited Peer-reviewed

      Ishiwata T

      Journal of Physical Fitness and Sports Medicine3 ( 4 ) 445 - 450   9 2014

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Effects of four consecutive light or moderate intensity exercise days on salivary secretory immunoglobulin A and mood in sedentary males. Peer-reviewed

          7 2012

      More details

      Language:Japanese   Publishing type:Research paper (scientific journal)  

      researchmap

    • 簡便な客観的指標によるストレス評価および個人に適した運動プログラム開発の重要性 -免疫グロブリンAの観点から-

      満石 寿, 石渡貴之, 濁川孝志, 大石和男

      立教大学コミュニティ福祉学部紀要14   127 - 140   3 2012

      More details

      Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

      researchmap

    • 大学生の腰痛と心理的要因の関連性 Peer-reviewed

      遠藤伸太郎, 和 秀俊, 石渡貴之, 加藤晴康, 安川道雄, 濁川孝志, 大石和男

      体力科学61 ( 1 ) 71 - 78   1 2012

      More details

      Language:Japanese   Publishing type:Research paper (scientific journal)  

      researchmap

    • Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats Peer-reviewed

      Hiroshi Hasegawa, Satomi Takatsu, Takayuki Ishiwata, Hideto Tanaka, Sophie Sarre, Romain Meeusen

      JOURNAL OF NEUROSCIENCE METHODS202 ( 2 ) 119 - 123   11 2011

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

      The purpose of the present study was to investigate the relationship between thermoregulation and catecholamine release in the preoptic area and anterior hypothalamus (PO/AH) during incremental treadmill running in the rat. To this aim, we combined in vivo brain microdialysis, biotelemetry and metabolic measurements for continuous monitoring of core body temperature (T-core), neurotransmitters and thermoregulatory responses. The animals were exercised for 1 h at 23 degrees C. Treadmill speed was increased every 20 min (10, 20 and 26 m min(-1)). T-core. oxygen consumption (VO2, an index of heat production) and tail skin temperature (T-tail, an index of heat loss) were simultaneously measured. Brain microdialysis samples were collected every 10 min, and these samples were analyzed for noradrenaline (NA), dopamine (DA) and serotonin (5-HT). T-core and VO2 significantly increased during treadmill and were exercise intensity dependent. After an initial drop T-tail increased significantly during exercise. Both NA and DA levels in the PO/AH increased significantly during exercise. There was no effect on serotonin release. T-core. VO2 and T-tail were positively correlated with the levels of NA and DA. Our data suggest that thermoregulatory responses are dependent on the intensity of the exercise and that these responses are associated with changes in NA and DA release, but not in 5-HT release in the PO/AH. (C) 2011 Elsevier B.V. All rights reserved.

      DOI: 10.1016/j.jneumeth.2011.05.024

      researchmap

    • 日本および中国における幼児の体温水準に関する調査研究 Peer-reviewed

      田中英登, 藤崎益代, 相原康二, 野本茂樹, 石渡貴之, 小谷泰則, 斉藤武比斗, 鈴木明

      体育研究44   5 - 10   7 2011

      More details

      Language:Japanese   Publishing type:Research paper (scientific journal)  

      researchmap

    • Serotonin release in the preoptic area and anterior hypothalamus is not involved in thermoregulation during low-intensity exercise in a warm environment Peer-reviewed

      Satomi Takatsu, Takayuki Ishiwata, Romain Meeusen, Sophie Sarre, Hiroshi Hasegawa

      NEUROSCIENCE LETTERS482 ( 1 ) 7 - 11   9 2010

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

      The aim of the present study was to assess the response of serotonin (5-hydroxytryptamine; 5-HT) in the preoptic area and anterior hypothalamus (PO/AH) to thermoregulation during exercise in a warm environment. In addition, it was investigated whether a rapid increase in extracellular 5-HT levels in the PO/AH modifies the thermoregulatory response under the same exercise conditions. Rats were made to run for 120 min at 10 m min(-1) on a treadmill at the ambient temperature of 30 degrees C. Body core temperature (T-core) was monitored using a biotelemetry system, and tail skin temperature (T-tail) was simultaneously measured as an index of heat loss response. Microdialysis in combination with HPLC was used to measure concentrations of monoamines in the PO/AH. Both T-core and T-tail increased during the first 20 min of exercise and remained stable until the end of the exercise period. Low-intensity exercise did not induce any changes in 5-HT release in the PO/AH, although the levels of norepinephrine and dopamine were increased. Moreover, increased extracellular 5-HT by local perfusion of 1 mu M citalopram (selective 5-HT reuptake inhibitor; SSRI) in the PO/AH had no effect on the thermoregulatory response during acute low-intensity exercise in a warm environment. These results suggest that enhanced release of only 5-HT in the PO/AH may not intervene thermoregulation during exercise in a warm environment. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

      DOI: 10.1016/j.neulet.2010.06.073

      researchmap

    • 身体運動実施後に観察された気分の改善

      大石和男, 遠藤伸太郎, 石渡貴之, 松尾哲矢, 福山清蔵

      立教大学コミュニティ福祉学部紀要12   1 - 10   3 2010

      More details

      Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

      researchmap

    • ベッドタウンにおける保育園児の生活習慣の男女差に関する研究ー睡眠に関する調査を中心にしてー

      石渡貴之, 田中英登, 小谷泰則, 相原康二

      立教大学スポーツ・健康科学23   1 - 8   3 2009

      More details

      Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

      researchmap

    • Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats

      Takehito Saito, Takayuki Ishiwata, Hiroshi Hasegawa, Shigeki Nomoto, Yasunori Kotani, Minoru Otokawa, Yasutsugu Aihara

      LIFE SCIENCES83 ( 1-2 ) 79 - 84   7 2008

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

      For this study, we compared the thermoregulatory involvement of noradrenaline (NA) in the medial preoptic area (mPOA) of non-cold acclimated rats to that of cold-acclimated rats. We quantified the release of NA in the mPOA during 3 h cold (5 degrees C) exposure in room-temperature-acclimated rats (RA group, kept at 23 degrees C for 2 weeks) and cold-acclimated rats (CA group, kept at 5 degrees C for 2 weeks). We concurrently monitored the core body temperature (T-c), heart rate (HR), and tail skin temperature (T-t). Cold exposure significantly increased T-c and HR, and decreased Tt in both groups. However, the cold-induced increase of the extracellular NA levels in mPOA was observed only in the RA group: not in the CA group. To elucidate these different results in NA levels further, and to evaluate participation of the mPOA in thermoregulation in the cold, we measured T-c, HR, and T-t during perfusion of alpha-adrenoceptor antagonist phenoxybenzamine during cold exposure (5 degrees C). This pharmacological procedure induced marked hypothermia, with decreases in HR only in the RA group; no changes were observed in T-c or any thermoregulatory parameter in the CA group. These results suggest that NA in the mPOA modulates heat production in response to acute cold stress in the RA group. However, this thermoregulatory action of NA in the mPOA was attenuated in the CA group. (C) 2008 Elsevier Inc. All rights reserved.

      DOI: 10.1016/j.lfs.2008.05.008

      researchmap

    • Influence of brain catecholamines on the development of fatigue in exercising rats in the heat. Peer-reviewed

      Hasegawa, H, Piacentini, M.F, Sarre, S, Michotte Y, Ishiwata, T, Meeusen, R

      Journal of Physiology586 ( 1 ) 141 - 149   3 2008

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Influence on human sleep patterns of lowering and delaying the minimum core body temperature by slow changes in the thermal environment Peer-reviewed

      Fumiharu Togo, Seika Aizawa, Jun-Ichiro Arai, Shoko Yoshikawa, Takayuki Ishiwata, Roy J. Shephard, Yukitoshi Aoyagi

      Sleep30 ( 6 ) 797 - 802   1 6 2007

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Academy of Sleep Medicine  

      Study Objectives: We hypothesized that appropriate changes in thermal environment would enhance the quality of sleep. Design/Setting: Controlled laboratory study. Participants: Healthy young men (n = 7, mean age 26 years). Interventions: Nocturnal sleep structures in semi-nude subjects were compared between a condition where an ambient temperature (Ta) of 29.5°C was maintained throughout the night (constant Ta), and a second condition (dynamic Ta) where Ta changed slowly within the thermoneutral range (from 27.5°C to 29.5°C). Measurements and Results: Statistically significant (P &lt
      0.05) results included a lower and a later occurrence of minimum core body temperature (Tc), and a longer duration of slow-wave (stages 3+4) sleep in dynamic versus constant T a. However, total sleep time, sleep efficiency, the total durations of light (stages 1+2) and rapid eye movement sleep, and the latencies to sleep onset, slow-wave sleep, and rapid eye movement sleep did not differ between conditions. Conclusions: Lowering the minimum and delaying the nadir of nocturnal Tc increases slow-wave sleep (probably by an increase of dry heat loss)
      use of this tactic might improve the overall quality of sleep.

      DOI: 10.1093/sleep/30.6.797

      Scopus

      PubMed

      researchmap

    • Influence on human sleep patterns of lowering and delaying the minimum core body temperature by slow changes in the thermal environment Peer-reviewed

      Furniharu Togo, Seika Aizawa, Jun-ichiro Arai, Shoko Yoshikawa, Takayuki Ishiwata, Roy J. Shephard, Yukitoshi Aoyagi

      SLEEP30 ( 6 ) 797 - 802   6 2007

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS INC  

      Study Objectives: We hypothesized that appropriate changes in thermal environment would enhance the quality of sleep.
      Design/Setting: Controlled laboratory study.
      Participants: Healthy young men (n = 7, mean age 26 years).
      Interventions: Nocturnal sleep structures in semi-nude subjects were compared between a condition where an ambient temperature (T-a) of 29.5 degrees C was maintained throughout the night (constant T-a), and a second condition (dynamic T-a) where T-a changed slowly within the thermoneutral range (from 27.5 degrees C to 29.5 degrees C).
      Measurements and Results: Statistically significant (P < 0.05) results included a lower and a later occurrence of minimum core body temperature (T.), and a longer duration of slow-wave (stages 3+4) sleep in dynamic versus constant T-a. However, total sleep time, sleep efficiency, the total durations of light (stages 1+2) and rapid eye movement sleep, and the latencies to sleep onset, slow-wave sleep, and rapid eye movement sleep did not differ between conditions.
      Conclusions: Lowering the minimum and delaying the nadir of nocturnal T c increases slow-wave sleep (probably by an increase of dry heat loss); use of this tactic might improve the overall quality of sleep.

      researchmap

    • Changes of body temperature and thermoregulatory responses of freely moving rats during GABAergic pharmacological stimulation to the preoptic area and anterior hypothalamus in several ambient temperatures. Peer-reviewed

      Ishiwata, T, Saito, T, Hasegawa, H, Yazawa, T, Kotani, Y, Otokawa, M, Aihara, Y

      Brain Research1048   32 - 40   5 2005

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • 連載健康のファラシー19 健康と睡眠(2) Invited

      石渡 貴之

      体育の科学 杏林書院Vol.56 ( 4月 ) 313 - 317   4 2005

      More details

      Language:Japanese   Publishing type:Research paper (other academic)  

      researchmap

    • 都会化地域と農村地域における幼児の生活習慣の比較に関する研究-睡眠に関する調査を中心にして- Peer-reviewed

      石渡 貴之

      児童研究第84   43 - 50   4 2005

      More details

      Language:Japanese   Publishing type:Research paper (scientific journal)  

      researchmap

    • 連載健康のファラシー18 健康と睡眠(1) Invited

      石渡 貴之

      体育の科学 杏林書院Vol.55 ( 3月 ) 235 - 238   3 2005

      More details

      Language:Japanese   Publishing type:Research paper (other academic)  

      researchmap

    • Inhibition of the preoptic area and anterior hypothalamus by tetrodotoxin alters thermoregulatory functions in exercising rats. Peer-reviewed

      Hasegawa, H, Ishiwata, T, Saito, T, Yazawa T, Aihara, Y, Meeusen, R

      Journal of Applied Physiology98   1458 - 1462   3 2005

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • Changes in monoamines in rat hypothalamus during cold acclimation Peer-reviewed

      Takehito Saito, Takayuki Ishiwata, Hiroshi Hasegawa, Shigeki Nomoto, Minoru Otokawa, Yasutsugu Aihara

      Journal of Thermal Biology30 ( 3 ) 229 - 235   2005

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier Ltd  

      Action of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) in the hypothalamus have been reported to play key roles in several homeostatic functions, including thermoregulation. The purpose of this study was to clarify differences in concentrations of NE, 5-HT and DA in several hypothalamic regions after cold exposure of different durations. Rats were exposed to a cold environment (5°C) for 3 hours (3H), 1 day (1D), 7 days (7D), 14 days (14D), or 28 days (28D). After cold exposure, each hypothalamic region was immediately extracted and homogenized. NE, 5-HT and DA in the extract were measured by high-performance liquid chromatography. We observed marked differences in the concentration of NE in each hypothalamic region after cold exposures. NE in the preoptic area was high only in the 3H group, while it was elevated in the 7D, 14D and 28D groups in the ventromedial hypothalamus. On the other hand, NE in the posterior hypothalamus was low in the 3H, 1D, 7D and 14D groups. Cold exposure did not affect concentrations of 5-HT and DA in these hypothalamic regions. Our results suggest the involvement of NE in each hypothalamic region in maintenance of body temperature, and that the neuronally active site in the hypothalamus seems to change during cold acclimation. © 2005 Published by Elsevier Ltd.

      DOI: 10.1016/j.jtherbio.2004.12.001

      Scopus

      researchmap

    • Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats. Peer-reviewed

      Ishiwata, T, Saito, T, Hasegawa, H, Yazawa, T, Otokawa, M, Aihara, Y

      Life Sciences75   2665 - 2675   9 2004

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • 体温調節機構におけるラット索前野/前視床下部の神経活動及び神経調節物質の機能的役割(英文)

      石渡貴之

          30 9 2002

      More details

      Language:English   Publishing type:Doctoral thesis  

      researchmap

    • Functional role of the preoptic area and anterior hypothalamus in thermoregulation in freely moving rats Peer-reviewed

      Ishiwata, T, Hasegawa, H, Yazawa, T, Otokawa, M, Aihara, Y

      Neuroscience Letters325   167 - 170   5 2002

      More details

      Language:English   Publishing type:Research paper (scientific journal)  

      researchmap

    • The role of preoptic area and anterior hypothalamus and median raphe nucleus on thermoregulatory system in freely moving rats Peer-reviewed

      T Ishiwata, H Hasegawa, M Yasumatsu, F Akano, T Yazawa, M Otokawa, Y Aihara

      NEUROSCIENCE LETTERS306 ( 1-2 ) 126 - 128   6 2001

      More details

      Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI IRELAND LTD  

      To clarify the role of the preoptic area and anterior hypothalamus (PO/AH) on thermoregulatory system and the effects of serotonergic innervation from the median raphe nucleus (MRN) on body temperature (Tb), we perfused tetrodotoxin (TTX) solution into the PO/AH or MRN by using a microdialysis technique at different ambient temperatures (5, 23 and 35 degreesC) in freely moving rats. Tb was continuously monitored by using a telemetry system. In the MRN, perfusion of TTX solution induced significant hypothermia in the normal environment, a greater decrease in Tb during cold exposure and had no effect on Tb during heat exposure. In the PO/AH, perfusion of TTX solution induced Significant hyperthermia in normal environment, a greater increase in Tb during heat exposure and had no effect on Tb during cold exposure. Our results indicate that the PO/AH regulates mainly heat loss or inhibits the loci regulating heat production. Furthermore, heat production appears to be regulated by other loci receiving serotonergic innervation from the MRN. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

      researchmap

    • 前額部加温による鼓膜温の変動と呼吸循環器系の応答

      石渡貴之

          31 3 1999

      More details

      Language:Japanese   Publishing type:Master’s thesis  

      researchmap

    ▼display all

    Misc.

    • 運動が心理指標と唾液中イムノグロブリンAの濃度に与え効果の検討 〜うつ病の社会復帰支援に向けて〜

      久保木祐生, 遠藤伸太郎, 石渡貴之, 大石和男, 加藤晴康, 杉浦克己, 濁川孝志, 松山真, 近藤智, 荻久保哲哉, 才田昌弘, 田中宏暁

      「うつ病者の社会的支援」および「自殺予防」に関するソーシャルモデル研究・開発 2013年度報告書   17 - 20   2014

      More details

      Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (bulletin of university, research institution)  

      researchmap

    • Comparison of monoaminergic neurotransmitters in the hypothalamic area under several environmental conditions

      Takayuki Ishiwata, Kota Suzuki, Chisa Ninomiya, Shinya Yanagita, Hiroshi Hasegawa

      JOURNAL OF PHYSIOLOGICAL SCIENCES63   S268 - S268   2013

      More details

      Language:English   Publishing type:Research paper, summary (international conference)   Publisher:SPRINGER JAPAN KK  

      researchmap

    • Body Temperature Regulation and Hypothalamic Catecholamines During Incremental Treadmill Running in Rats

      Hiroshi Hasegawa, Satomi Takatsu, Takayuki Ishiwata, Romain Meeusen

      MEDICINE AND SCIENCE IN SPORTS AND EXERCISE42 ( 5 ) 660 - 660   5 2010

      More details

      Language:English   Publishing type:Research paper, summary (international conference)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

      researchmap

    • Effects of heat- and cold-acclimation on thermo-regulatory responses in rats

      Shigeki Nomoto, Emi Nomoto, Takayuki Ishiwata, Takehito Saito, Hideto Tanaka, Yasunori Kotani, Hideaki Murakami, Yasutsugu Aihara

      JOURNAL OF PHYSIOLOGICAL SCIENCES60   S188 - S188   2010

      More details

      Language:English   Publishing type:Research paper, summary (international conference)   Publisher:SPRINGER TOKYO  

      researchmap

    • 老化ラットの暑熱寒冷順化後の体温調節能力

      野本茂樹, 野本惠美, 石渡貴之, 齋藤武比斗, 田中英登, 小谷泰則, 村上秀明, 相原康二

      Biomedical Thermology27 ( 1 ) 40   10 8 2007

      More details

      Language:Japanese  

      J-GLOBAL

      researchmap

    • 暑熱寒冷順化ラットの体温調節能力 I. 若齢および成熟ラットの場合

      野本惠美, 齋藤武比斗, 石渡貴之, 田中英登, 小谷泰則, 村上秀明, 相原康二, 野本茂樹

      基礎老化研究30 ( 2 ) 28   26 5 2006

      More details

      Language:Japanese  

      J-GLOBAL

      researchmap

    ▼display all

    Books and Other Publications

    • 生理学 (はじめて学ぶ健康・スポーツ科学シリーズ)第10章 自律神経系

      石渡 貴之, 村上 秀明, 依田 珠江, 長谷川 博, 須田 和裕( Role: Joint author)

      化学同人  10 8 2015  ( ISBN:9784759817027

      More details

      Language:Japanese Book type:Textbook, survey, introduction

      researchmap

    • 生理学 (はじめて学ぶ健康・スポーツ科学シリーズ)第11章 脳

      石渡 貴之, 村上 秀明, 依田 珠江, 長谷川 博, 須田 和裕( Role: Joint author)

      化学同人  10 8 2015  ( ISBN:9784759817027

      More details

      Language:Japanese Book type:Textbook, survey, introduction

      researchmap

    • 新・コミュニティ福祉学入門,4. 生活習慣とウエルネス?生理学的・神経科学的観点からのアプローチ?(第Ⅱ部 ウエルネス・コミュニティの創造,第9章)

      坂田周一監修, 浅井春夫, 三本松政之, 濁川孝志( Role: Joint author)

      有意閣  1 4 2013 

      More details

      Language:Japanese Book type:Scholarly book

      researchmap

    • 新・コミュニティ福祉学入門,4. 生活習慣とウエルネス−生理学的・神経科学的観点からのアプローチ−(第Ⅱ部 ウエルネス・コミュニティの創造,第9章)

      坂田周一監修, 浅井春夫, 三本松政之, 濁川孝志( Role: Joint author)

      有意閣  1 4 2013 

      More details

      Language:Japanese Book type:Scholarly book

      researchmap

    • 障害者スポーツにおける科学的サポートの可能性と課題 ?車椅子バスケットボールを対象として?

      依田珠江, 安松幹展, 石渡貴之( Role: Joint author)

      世界思想社  1 6 2010 

      More details

      Language:Japanese Book type:Scholarly book

      researchmap

    • 障害者スポーツにおける科学的サポートの可能性と課題 −車椅子バスケットボールを対象として−

      依田珠江, 安松幹展, 石渡貴之( Role: Joint author)

      世界思想社  1 6 2010 

      More details

      Language:Japanese Book type:Scholarly book

      researchmap

    • からだと温度の事典,12. 子供の運動と体温調節

      彼末一之( Role: Sole author)

      朝倉書店  1 4 2010 

      More details

      Language:Japanese Book type:Scholarly book

      researchmap

    • ニューロサイエンスと子どものこころとからだ?いい脳を育てるいいインターフェースになろう!?

      ( Role: Other)

      田研出版  7 2007 

      More details

      Language:Japanese Book type:Other

      researchmap

    • ニューロサイエンスと子どものこころとからだ〜いい脳を育てるいいインターフェースになろう!〜

      ( Role: Other)

      田研出版  7 2007 

      More details

      Language:Japanese Book type:Other

      researchmap

    ▼display all

    Professional Memberships

    ▼display all

    Research Projects

    • 環境ストレスが生理指標,脳内神経伝達物質,情動行動に及ぼす影響

      More details

      4 2012 - Present

      Grant type:Competitive

      researchmap

    • 体温調節機構における脳内神経伝達物質の役割解明

      科学研究費補助金 

      More details

      4 1998 - Present

      Grant type:Competitive

      研究目的:
      我々ヒトを含む恒温動物は、個体内部の熱産生量が増えた時や外界の温度が変動した時に、深部体温を一定の範囲内に保つ体温調節機能を備えている。しかしながら、近年の異常気象から、スポーツ中の熱中症が増えており、また、高齢者にとっても熱中症は重要な問題となっている。熱中症の事故は、地球温暖化の影響もあるが、体温調節機能の低下も一因になっていると考えられる。今後益々地球温暖化が進む中で、体温調節機能の維持、向上は重要な課題であり、その中枢における基本的なメカニズムを解明する必要がある。
      脳内の調節機構には、神経細胞を促進または抑制する神経伝達物質の働きが極めて重要である。本研究では体温調節機構における神経伝達物質の役割を明らかにすることを目的としている。

      研究方法:
      神経伝達物質の回収、測定にはマイクロダイアリシス-HPLC法を用い、体温の測定にはテレメトリー法を用いている。これらの手法を組み合わせることにより無麻酔無拘束による測定が可能となる。

      結果と考察:
      これまでの結果、体温調節において最も重要と考えられている視索前野/前視床下部(PO/AH)の役割は、主に熱産生を抑制していることが明らかになった。また、この熱産生の抑制の解除に関与するPO/AHの神経伝達物質はノルエピネフリンとガンマアミノ酪酸(GABA)であり、熱放散に関与する神経伝達物質はドーパミンである可能性が明らかになった。これまで体温調節機構において重要だと考えられてきたPO/AHのセロトニンは、関与しないことが明らかになった。この様に、PO/AHにおける体温調節機構には、複数の神経伝達物質が複雑な相互関係により調節していることを明らかにした。

      researchmap

    • 暑熱環境下での体調管理に関する神経生理学的アプローチ

      日本学術振興会  科学研究費助成事業 

      石渡貴之

      More details

      4 2020 - 3 2023

      Grant type:Competitive

      近年,地球温暖化が世界中で大きな問題となっており,熱中症による健康被害が増加している.また,体調不良時には熱中症になりやすいことが経験的に認識されているが,その詳細なメカニズムについては明らかになっていない.これまで本研究者はラットを用いた研究にて,不規則な照明環境下での生活が深部体温や心拍数の生体リズムを乱し,様々な生体機能の調節を司る脳内神経伝達物質の乱れを誘発し,それらが不安様行動を惹起することを明らかにしている.すなわち,この状態が体調不良モデルと考えられる.そこで,本研究では,生体リズムの乱れに伴う体調不良が暑熱環境下での生理指標(深部体温,心拍数,活動量),脳内神経伝達物質(セロトニン,ドーパミン,ノルアドレナリン),不安様行動,認知機能に及ぼす影響を明らかにすることを目的とする.更に熱中症予防としての暑熱順化や運動の効果を神経生理学的観点から検討し,教育やスポーツの現場に還元することを目標とする.

      researchmap

    • 自発運動が社会的隔離ストレス下の生理指標,脳内神経伝達物質,情動行動に及ぼす影響

      日本学術振興会  科学研究費助成事業 

      More details

      4 2017 - 3 2020

      Grant type:Competitive

      researchmap

    • 自発運動が体温調節及び視索前野/前視床下部の脳内神経伝達物質に及ぼす影響

      日本学術振興会  科学研究費助成事業 

      石渡貴之

      More details

      4 2014 - 3 2017

      Authorship:Principal investigator  Grant type:Competitive

      researchmap

    • 体温調節機構における視床下部熱産生領域の神経伝達物質の役割解明

      日本学術振興会  科学研究費助成事業 

      More details

      4 2011 - 3 2013

      Grant type:Competitive

      本研究では,熱産生系に関与する部位である視床下部腹内側核(Dorsomedial Hypothalamus: DMH)と後視床下部(Posterior Hypotyaklamus:PH)に注目し,DMHとPHの体温調節機構における神経伝達物質の役割を解明する.
      初年度は体温調節が活発になる暑熱暴露時(35℃)及び寒冷暴露時(5℃)のDMH,PHの神経伝達物質放出量(5-HT,DA,NE)の経時的変化を測定し,温熱刺激による反応を検討する.
      次年度は,候補となる神経伝達物質の作動薬と抑制薬によりDMHとPHの神経伝達物質量を変化させた時の深部体温,熱産生反応(心拍変動)と熱放散反応(皮膚温変動)を測定することにより,DMHとPHの体温調節機構における役割を明確にする.

      researchmap

    • 体温調節機構におけるセロトニンネットワークの役割解明

      日本学術振興会  科学研究費助成事業 

      More details

      4 2009 - 3 2011

      Grant type:Competitive

      本研究では,熱放散系に関与する部位である腹側被蓋野(Ventral tegmental area; VTA)に注目し,VTAの体温調節機構における5-HTの役割を解明する.初年度は体温調節が活発になる暑熱暴露時及び寒冷暴露時のVTAの5-HT放出量の経時的変化を測定し,温熱刺激による反応を検討する.更に暴露中にテトロドトキシンによりVTAの神経活動を抑制したときの体温調節反応を観察する.
      次年度は,複数の5-HT作動薬によりVTAの5-HT量を変化させた時の深部体温,熱産生反応(心拍変動)と熱放散反応(皮膚温変動)を測定することにより,VTAの体温調節機構における5-HTの役割を明確にする.

      researchmap

    • 体温調節機構におけるセロトニンの役割解明

      科学研究費助成事業 

      More details

      4 2006 - 3 2008

      Grant type:Competitive

      脳内セロトニン(5-HT)は体温調節機構において重要な神経伝達物質であることが示唆されている。本研究では体温調節機構における5-HTの役割を解明するため、ナトリウムチャネルブロッカーであるテトロドトキシン(TTX)により、5-HTの細胞体が存在する背側縫線核(DRN)の神経活動を抑制した時の体温調節反応を測定した。また前年度行った、正中縫線核(MRN)の神経活動を抑制した時の体温調節反応と比較検討し、両部位の体温調節機構における機能的差異の考察を深めた。
      実験は昨年度と同様に、無麻酔・無拘束ラットにおいて、マイクロダイアリシス法、テレメトリー法に加え、熱産生反応の指標の心拍数と熱放散反応の指標の尾部皮膚温の測定を行った。実験は全て明期の間に行い、全ての実験は測定開始から1時間を安静期間とした。測定開始60分後の平均体温、心拍数および尾部皮膚温を基準値として統計分析を行った。環境温度は23℃の下で行い、1時間の安静期間後にTTX(5μM)溶液の灌流を1時間行った。なお、TTX溶液灌流中以外は生理食塩水を灌流した。実験終了後にはプローブ挿入位置を染色し、脳を摘出し、ホルマリン固定後に脳部位の確認を行った。
      DRNへのTTX灌流投与により、有意な体温低下(約3.5℃)が観察された。この体温低下に先立ち、熱放散反応の指標である尾部皮膚温は急激な上昇(約5℃)を示した。熱産生反応の指標である心拍数は変化しなかった。以上の結果より、DRNへのTTX灌流投与後に起きる体温低下は、主に熱放散が上昇したことによると考えられた。また、これらの結果は前年度行ったMRNへのTTX灌流投与時とほぼ同じであり、体温調節機構におけるDRN、MRNの機能的差異は無く、両部位からの5-HT投射の役割は、主に熱放散系に関与していることが示唆された。

      researchmap

    ▼display all

    Social Contribution

    • レクリエーション・コーディネーター

      4 2012 - Present

      More details

    • キャンプインストラクター

      More details

    • レクリエーションインストラクター

      More details

    • 幼児体育指導者2級

      More details