Updated on 2021/06/22

写真b

 
MATSUYAMA Shinichi
 
*Items subject to periodic update by Rikkyo University (The rest are reprinted from information registered on researchmap.)
Affiliation*
College of Science Department of Life Science
Graduate School of Science Field of Study: Life Science
Graduate School of Science Field of Study: Life Science
Title*
Professor
Degree
Doctor / 農学博士 ( 名古屋大学 ) / Doctor
Contact information
Mail Address
Research Theme*
  • 膜タンパク質の解析を通して、生体膜の新しい機能を見いだす。生体膜の構成成分であるリン脂質やタンパク質などがどのように輸送され膜に組み込まれるのかを調べて、生体膜の生合成機構を明らかにする。取り扱いが容易な大腸菌を材料として、生化学的手法を中心に遺伝学、細胞生物学的手法も駆使して研究を進める。

  • Research Interests
  • membrane

  • Molecular Biology

  • Biochemistry

  • Escherichia coli

  • 大腸菌

  • Campus Career*
    • 4 2003 - Present 
      College of Science   Department of Life Science   Professor
    • 4 2003 - Present 
      Graduate School of Science   Field of Study: Life Science   Professor
    • 4 2003 - Present 
      Graduate School of Science   Field of Study: Life Science   Professor
     

    Research Areas

    • Life Science / Functional biochemistry

    • Life Science / Genetics

    Research History

    • 4 2003 - Present 
      RIKKYO UNIVERSITY   Graduate School of Science Field of Study: Life Science   Professor

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    • 4 2003 - Present 
      RIKKYO UNIVERSITY   College of Science Department of Life Science   Professor

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    • 4 2003 - Present 
      RIKKYO UNIVERSITY   Graduate School of Science Field of Study: Life Science   Professor

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    • 6 1995 - 3 2003 
      The University of Tokyo   Institute of Molecular and Cellular Biosciences

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    • 4 1993 - 5 1995 
      The University of Tokyo   Institute of Molecular and Cellular Biosciences

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    • 12 1987 - 3 1993 
      東京大学応用微生物研究所   助手

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    • 12 1987 - 3 1993 
      東京大学応用微生物研究所   助手

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    • 1 1986 - 11 1987 
      東京大学応用微生物研究所   職員(教務系)

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    • 1 1986 - 11 1987 
      東京大学応用微生物研究所   職員(教務系)

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    Education

    • - 12 1985 
      Nagoya University   Graduate School, Division of Agriculture

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      Country: Japan

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    • - 3 1984 
      Nagoya University   Graduate School, Division of Agriculture

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      Country: Japan

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    • - 3 1982 
      Shizuoka University   Faculty of Science

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      Country: Japan

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    • - 10 1976 
      Kumamoto University   Faculty of Science

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      Country: Japan

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    Awards

    • 1 1993  
      日本農芸化学会  農芸化学奨励賞 

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      Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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    Papers

    • 大腸菌リポタンパク質の選択的膜局在化機構

      松山 伸一

      実験医学 ( 21 ) 874 - 879   1 1 2003

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      Language:Japanese   Publishing type:Research paper (other academic)  

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    • A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoprotein against their inner membrane specific signals

      松山 伸一

      Mol. Microbiol.   1 1 2003

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      Language:English   Publishing type:Research paper (other academic)  

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    • Amino-acylation of the N-terminal cysteine is essential for Lol-dependent release of lipoproteins from membranes but does not depend on lipoprotein sorting

      松山 伸一

      J. Bio. Chem.   1 1 2003

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    • Crystallization and preliminary crystallographic stydy of the outer membrane lipoprotein receptor LolB, a member of the lipoprotein localization factor

      松山 伸一

      Acta Crystallogy. D.   1 1 2003

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    • Disruption of lolCDE encoding an ATP-dependent cassette transporter is lethal for Escherichia coli and prevents the release of lipoproteins from the inner membrane

      松山 伸一

      J. Bacteriol. ( 184 ) 1417 - 14222   1 1 2002

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    • Dominant-negative mutant of a lipoprotein-specific molecular chaperone, LolA, tightly associates with LolCDE

      松山 伸一

      FEBS Lett. ( 528 ) 193 - 196   1 1 2002

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    • Elucidation of the function of lipoprotein-sorting signals that determine membrane localization

      松山 伸一

      Proc. Natl. Acad. Sci. USA ( 99 ) 7390 - 7395   1 1 2002

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    • Deletion of LolB encoding an Outer membrane lipoprotein is lethal for Escherichia coli and causes the accumulation of lipoprotein localization intermediate in the periplasm

      松山 伸一

      J. Bacteriol. ( 183 ) 6538 - 6542   1 1 2001

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    • Lipoprotein-sorting signals evaluated as the Lol-dependent release of lipoproteins from the cytoplasmic membrane of Escherichia coli

      松山 伸一

      J. Bio. Chem. ( 276 ) 47690 - 47694   1 1 2001

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    • A new ABC transporter mediating the detachment of lipid-modified proteins from membranes

      松山 伸一

      Nature Cell Biol. ( 2 ) 212 - 218   1 1 2000

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    • Characterization of the LolA-LolB system as the general lipoprotein localization mechanism of Escherichia coli

      松山 伸一

      J. Bio. Chem. ( 274 ) 30995 - 30999   1 1 1999

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    • LolA-dependent release of a lipid-modified protein from the inner membrane of Escherichia coli requires nucleoside triphosphate

      松山 伸一

      J. Bio. Chem. ( 273 ) 32576 - 32581   1 1 1998

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    • A novel outer membrane protein, LolB(HemM), involved in the LolA(p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli

      松山 伸一

      EMBO J. ( 16 ) 6947 - 6955   1 1 1997

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    • Lethality of the covalent linkage between mislocalized major outer membrane lipoprotein and the peptidoglycan of Escherichia coli

      松山 伸一

      J. Bacteriol. ( 179 ) 2857 - 2862   1 1 1997

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    • The carboxy-terminal region is essential for SecA dimerization

      Biochem. Biophys. REs. Commun.229   90   4 1996

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    • 大腸菌リポタンパク質の局在化機構:脂肪酸で修飾されたタンパク質の選別輸送

      蛋白質・核酸・酵素   4 1995

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    • A novel periplasmic carrier protein involved in sorting and transport of ┣DBE coli(/)-┫DB lipoprotein destined for the outer membrane.

      EMBO Journal14 ( 13 )   4 1995

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    • A Novel periplasmic carrier protein involved in sorting and transport of Escherichia coli lipoproteins destinated for the outer membrane

      松山 伸一

      EMBO J. ( 14 ) 3365 - 3372   1 1 1995

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    • 大腸菌のタンパク質膜透過装置

      日本農芸化学会誌68 ( 2 ) 213   4 1994

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    • SecF stabilized SecD and SecY, components of the protein translocation machinery of the Escherichia coli cytoplasmic membrane

      松山 伸一

      J. Bacteriol. ( 176 ) 4111 - 4116   1 1 1994

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    • SecD is involved in the release of translocated secretory proteins from the cytoplasmic membrane of Escherichia coli

      松山 伸一

      EMBO J. ( 12 ) 265 - 270   1 1 1993

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    • Large-scale production of membranes fused to a truncated SecA in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB.

      Bioscience, Biotechnology and Biochemistry56   4 1992

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    • Overproduction, purification and characterization of SecD and SecF, integral membrane components of the protein translocation machinery of ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB.

      Biochimica et Biophysica Acta1122   4 1992

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    • Determination of a domain in SecA that interacts with presecretory proteins in Escherichia coli

      松山 伸一

      J. Bio. Chem. ( 266 ) 6600 - 6606   1 1 1991

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    • Reconstitution of a secretory machinery from purified SecY, SecE and SecA of Escherichia coli

      松山 伸一

      Proc. Natl. Acad. Sci. USA ( 88 ) 6545 - 6549   1 1 1991

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    • Complementation of two overlapping fragments of SecA, a protein translocation ATPase of ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB, allows ATP binding to its amino-terminal region.

      Journal of Biological Chemistry265   4 1990

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    • SecE-dependent overproduction of SecY in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB : Evidence for interaction between two components of the secretory machinery.

      FEBS Letters269   4 1990

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    • In vitro kinetic analysis of the role of the positive charge at the amino-terminal region of signal peptides in translocation of secretory protin across the cytoplasmic membrane in Escherichia coli

      松山 伸一

      J. Bio. Chem. ( 265 ) 4358 - 4363   1 1 1990

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    • Energy-dependent ┣DBin(/)-┫DB ┣DBvitro(/)-┫DB translocation of a model protein into ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB inverted membrane vesicles can take place efficiently

      Journal of Biological Chemistry264   4 1989

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    • Novel ┣DBrpoA(/)-┫DB mutation that interferes with the function of OmpR and EnvZ, positive regulators of the ┣DBompF(/)-┫DB and ┣DBompC(/)-┫DB genes that code for outer-membrane proteins in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB K12.

      Journal of Molecular Biology195   4 1987

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    • Interaction between two regulatory proteins in osmoregulatory expression of ┣DBomoF(/)-┫DB and ┣DBompC(/)-┫DB genes in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB : a novel ┣DBompR(/)-┫DB mutation suppresses pleiotropic defects caused by an ┣DBenvZ(/)-┫DB mutati

      Journal of Bacteriology168   4 1986

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    • Construction and characterization of a deletion mutant lacking ┣DBmicF(/)-┫DB, a proposed regulatory gene for OmpF synthesis in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB.

      Journal of Bacteriology162   4 1985

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    • Promoter exchange between ┣DBompF(/)-┫DB and ┣DBompC(/)-┫DB, genes for osmoregulated mafor outer membrane proteins of ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB K-12.

      Journal of Bacteriology159   4 1984

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    Books and Other Publications

    • Protein traffic from the Cytosol to the outer membrane of Escherichia coli

      ( Role: Other)

      Protein targeting and translocation  4 1998 

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      Language:English Book type:Other

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    • Biochemical analyses of components comprising the translocation machinery of ┣DBEscherichia coli(/)-┫DB

      ( Role: Other)

      Advances in Cell and Molecular Biology of Membranes and Organelles  4 1995 

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      Language:English Book type:Other

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    Works

    • University of Medicine and Dentistry of New Jersey Other

      10 1997
      -
      8 1998

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    • University of Connecticut Health Center Other

      1 1997
      -
      10 1997

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    Research Projects

    • 大腸菌細胞表層におけるリポタンパク質の選択的膜局在化と品質管理の分子機構

      文部科学省  科学研究費助成事業 

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      4 2002 - 3 2007

      Grant type:Competitive

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    • 大腸菌の生育に必須の細胞表層蛋白質を標的とする化学療法剤開発の基礎研究

      日本学術振興会  科学研究費助成事業 

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      4 2003 - 3 2006

      Grant type:Competitive

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    • 外膜リポ蛋白質のみを選別して膜から遊離させるABCトランスポーターの機能解析

      日本学術振興会  科学研究費助成事業 

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      4 2000 - 3 2003

      Grant type:Competitive

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    • グラム陰性細菌のリポ蛋白質を標的とする化学療法剤の開発

      文部科学省  科学研究費助成事業 

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      4 2001 - 3 2002

      Grant type:Competitive

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    • 大腸菌細胞表層におけるリポ蛋白質ネットワークの解明

      文部科学省  科学研究費助成事業 

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      4 2001 - 3 2002

      Grant type:Competitive

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    • 大腸菌の全リポ蛋白質遺伝子の網羅的解析

      文部科学省  科学研究費助成事業 

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      4 2000 - 3 2001

      Grant type:Competitive

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    • タンパク質の局在化機構

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      Grant type:Competitive

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    • 生体膜の生合成

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      Grant type:Competitive

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    • Membrane Biogenesis

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      Grant type:Competitive

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    • Protein Translocation

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      Grant type:Competitive

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