Updated on 2021/06/22

写真b

 
SEKINE Yasuhiko
 
*Items subject to periodic update by Rikkyo University (The rest are reprinted from information registered on researchmap.)
Affiliation*
College of Science Department of Life Science
Graduate School of Science Field of Study: Life Science
Graduate School of Science Field of Study: Life Science
Title*
Professor
Degree
博士(農学) ( 東京大学 ) / 博士(農学) ( 東京大学 )
Contact information
Mail Address
Research Theme*
  • バクテリア(大腸菌)および植物(ヒメツリガネゴケ、クラミドモナス)を材料にして、主に分子生物学的手法を用いて以下の研究を行っている。1染色体、オルガネラDNAの組換え・修復・維持の機構、動く遺伝子(トランスポゾン)の転移調節機構。2非翻訳型RNA(noncoding RNA)の機能。3バクテリアの細胞内共生によるオルガネラ誕生のプロセスを支えた諸機構の解明。

  • Research Interests
  • translation

  • genome dynamics

  • tRNA

  • transposon

  • plant organella

  • Campus Career*
    • 4 2011 - Present 
      College of Science   Department of Life Science   Professor
    • 4 2011 - Present 
      Graduate School of Science   Field of Study: Life Science   Professor
    • 4 2011 - Present 
      Graduate School of Science   Field of Study: Life Science   Professor
    • 4 2007 - 3 2011 
      College of Science   Department of Life Science   Associate Professor
    • 4 2002 - 3 2007 
      College of Science   Department of Life Science   Associate Professor (as old post name)
    • 4 2001 - 3 2002 
      College of Science   Department of Chemistry   Associate Professor (as old post name)
     

    Research Areas

    • Life Science / Molecular biology

    Research History

    • 4 2011 - Present 
      RIKKYO UNIVERSITY   Graduate School of Science Field of Study: Life Science   Professor

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    • 4 2011 - Present 
      RIKKYO UNIVERSITY   Graduate School of Science Field of Study: Life Science   Professor

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    • 4 2011 - Present 
      RIKKYO UNIVERSITY   College of Science Department of Life Science   Professor

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    • 4 2007 - 3 2011 
      RIKKYO UNIVERSITY   College of Science Department of Life Science   Associate Professor

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    • 4 2002 - 3 2007 
      RIKKYO UNIVERSITY   College of Science Department of Life Science   Associate Professor (as old post name)

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    • 4 2001 - 3 2002 
      RIKKYO UNIVERSITY   College of Science Department of Chemistry   Associate Professor (as old post name)

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    • 4 1991 - 3 2001 
      Institute of Molecular and Cellular Biosciences, Tokyo University   Full-time Research Assistant

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    • 4 1991 - 3 2001 
      Institute of Molecular and Cellular Biosciences, Tokyo University   Full-time Research Assistant

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    Education

    • - 3 1991 
      The University of Tokyo   Graduate School, Division of Agricultural Science

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      Country: Japan

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    • - 3 1988 
      The University of Tokyo   Graduate School, Division of Agricultural Science

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      Country: Japan

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    • - 3 1986 
      The University of Tokyo   Faculty of Agriculture

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      Country: Japan

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    Committee Memberships

    • 4 2010 - Present 
      日本遺伝学会   幹事(広報担当・ホームページ編集)

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      Committee type:Academic society

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    • 4 2009 - 3 2010 
      日本遺伝学会   評議員

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      Committee type:Academic society

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    • 4 2007 - 3 2009 
      日本遺伝学会   会計監査

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      Committee type:Academic society

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    Awards

    • 1 2002  
      日本遺伝学会  日本遺伝学会 奨励賞 

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      Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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    Papers

    • RECX interacts with mitochondrial RECA to maintain mitochondrial genome stability. Peer-reviewed

      Masaki Odahara, Yasuhiko Sekine

      Plant Physiology177 ( 1 ) 300 - 310   5 2018

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Society of Plant Biologists  

      DOI: 10.1104/pp.18.00218

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    • MSH1 maintains organelle genome stability and genetically interacts with RECA and RECG in the moss Physcomitrella patens. Peer-reviewed

      Odahara M, Kishita Y, Sekine Y

      Plant Journal91 ( 3 ) 455 - 456   13 4 2017

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

      DOI: 10.1111/tpj.13573

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    • PCR-based Assay for Genome Integrity after Methyl Methanesulfonate Damage in Physcomitrella patens. Peer-reviewed

      Masaki Odahara, Takayuki Inouye, Yoshiki Nishimura, Yasuhiko Sekine

      bio-protocol6 ( 19 ) e1954   10 5 2016

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      Language:English   Publishing type:Research paper (scientific journal)  

      DOI: 10.21769/BioProtoc.1954

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    • RECA plays a dual role in the maintenance of chloroplast genome stability in Physcomitrella patens Peer-reviewed

      Masaki Odahara, Takayuki Inouye, Yoshiki Nishimura, Yasuhiko Sekine

      Plant Journal84 ( 3 ) 516 - 526   1 11 2015

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:Blackwell Publishing Ltd  

      Chloroplast DNA (cpDNA) encodes essential genes for chloroplast functions, including photosynthesis. Homologous recombination occurs frequently in cpDNA
      however, its significance and underlying mechanism remain poorly understood. In this study, we analyzed the role of a nuclear-encoded chloroplast-localized homolog of RecA recombinase, which is a key factor in homologous recombination in bacteria, in the moss Physcomitrella patens. Complete knockout (KO) of the P. patens chloroplast RecA homolog RECA2 caused a modest growth defect and conferred sensitivity to methyl methanesulfonate and UV. The KO mutant exhibited low recovery of cpDNA from methyl methanesulfonate damage, suggesting that RECA2 knockout impairs repair of damaged cpDNA. The RECA2 KO mutant also exhibited reduced cpDNA copy number and an elevated level of cpDNA molecule resulting from aberrant recombination between short dispersed repeats (13-63 bp), indicating that the RECA2 KO chloroplast genome was destabilized. Taken together, these data suggest a dual role for RECA2 in the maintenance of chloroplast genome stability: RECA2 suppresses aberrant recombination between short dispersed repeats and promotes repair of damaged DNA. Significance Statement Chloroplast DNA encodes essential genes for photosynthesis and chloroplast gene expression. Here we show that the chloroplast RecA homolog maintains chloroplast genomic DNA integrity, both by repairing damaged DNA and by suppressing aberrant recombination between short dispersed repeats.

      DOI: 10.1111/tpj.13017

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    • RECG Maintains Plastid and Mitochondrial Genome Stability by Suppressing Extensive Recombination between Short Dispersed Repeats Peer-reviewed

      Masaki Odahara, Yuichi Masuda, Mayuko Sato, Mayumi Wakazaki, Chizuru Harada, Kiminori Toyooka, Yasuhiko Sekine

      PLoS Genetics11 ( 3 ) e1005080.   13 3 2015

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science  

      Maintenance of plastid and mitochondrial genome stability is crucial for photosynthesis and respiration, respectively. Recently, we have reported that RECA1 maintains mitochondrial genome stability by suppressing gross rearrangements induced by aberrant recombination between short dispersed repeats in the moss Physcomitrella patens. In this study, we studied a newly identified P. patens homolog of bacterial RecG helicase, RECG, some of which is localized in both plastid and mitochondrial nucleoids. RECG partially complements recG deficiency in Escherichia coli cells. A knockout (KO) mutation of RECG caused characteristic phenotypes including growth delay and developmental and mitochondrial defects, which are similar to those of the RECA1 KO mutant. The RECG KO cells showed heterogeneity in these phenotypes. Analyses of RECG KO plants showed that mitochondrial genome was destabilized due to a recombination between 8–79 bp repeats and the pattern of the recombination partly differed from that observed in the RECA1 KO mutants. The mitochondrial DNA (mtDNA) instability was greater in severe phenotypic RECG KO cells than that in mild phenotypic ones. This result suggests that mitochondrial genomic instability is responsible for the defective phenotypes of RECG KO plants. Some of the induced recombination caused efficient genomic rearrangements in RECG KO mitochondria. Such loci were sometimes associated with a decrease in the levels of normal mtDNA and significant decrease in the number of transcripts derived from the loci. In addition, the RECG KO mutation caused remarkable plastid abnormalities and induced recombination between short repeats (12–63 bp) in the plastid DNA. These results suggest that RECG plays a role in the maintenance of both plastid and mitochondrial genome stability by suppressing aberrant recombination between dispersed short repeats
      this role is crucial for plastid and mitochondrial functions.

      DOI: 10.1371/journal.pgen.1005080

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    • Identification of highly-disrupted tRNA genes in nuclear genome of the red alga, Cyanidioschyzon merolae 10D Peer-reviewed

      Akiko Soma, Junichi Sugahara, Akinori Onodera, Nozomu Yachie, Akio Kanai, Satoru Watanabe, Hirofumi Yoshikawa, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yasuhiko Sekine

      SCIENTIFIC REPORTS3   2321   7 2013

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      Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

      The limited locations of tRNA introns are crucial for eukaryal tRNA-splicing endonuclease recognition. However, our analysis of the nuclear genome of an early-diverged red alga, Cyanidioschyzon merolae, demonstrated the first evidence of nuclear-encoded tRNA genes that contain ectopic and/or multiple introns. Some genes exhibited both intronic and permuted structures in which the 3'-half of the tRNA coding sequence lies upstream of the 5'-half, and an intron is inserted into either half. These highly disrupted tRNA genes, which account for 63% of all nuclear tRNA genes, are expressed via the orderly and sequential processing of bulge-helix-bulge (BHB) motifs at intron-exon junctions and termini of permuted tRNA precursors, probably by a C. merolae tRNA-splicing endonuclease with an unidentified subunit architecture. The results revealed a considerable diversity in eukaryal tRNA intron properties and endonuclease architectures, which will help to elucidate the acquisition mechanism of the BHB-mediated disrupted tRNA genes.

      DOI: 10.1038/srep02321

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    • Nitrate assimilatory genes and their transcriptional regulation in a unicellular red alga Cyanidioschyzon merolae: Genetic evidence for nitrite reduction by a sulfite reductase-like enzyme. Peer-reviewed

      Imamura, S, Terashita, M, Ohnuma, M, Maruyama, S, Minoda, A, Weber, A. P. M, Inouye, T, Sekine, Y, Fujita, Y, Omata, T, Tanaka, K

      Plant & Cell Physiology51   707 - 717   1 2010

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    • Measurements of transposition frequency of insertion sequence IS1 by GFP hop-on assay Peer-reviewed

      Takashi Saito, Taku Chibazakura, Kiwamu Takahashi, Hirofumi Yoshikawa, Yasuhiko Sekine

      Journal of General and Applied Microbiology56 ( 3 ) 187 - 192   2010

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      Transposons play a significant role in the evolution of bacterial genomes. Quantifying frequency of transpositional events caused by a transposon will facilitate understanding its role. Here, we report successful measurement of the frequency of IS1 transposition using "GFP hop-on assay" in which transposition-dependent GFP expression is monitored by FACS. This assay allows easy assessment of IS transposition into the chromosomal DNA on a single-cell scale
      this is an advantage over other conventional methods to measure transposition frequency.

      DOI: 10.2323/jgam.56.187

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    • R2R3-type MYB transcription factor, CmMYB1, is a central nitrogen assimilation regulator in Cyanidioschyzon merolae. Peer-reviewed

      Imamura, S, Kanesaki, Y, Ohnuma, M, Inouye, T, Sekine, Y, Fujiwara, T, Kuroiwa, T, Tanaka, K

      Proc. Natl. Acad. Sci. U S A106   12548 - 12553   1 2009

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    • R2R3-type MYB transcription factor, CmMYB1, is a central nitrogen assimilation regulator in Cyanidioschyzon merolae. Peer-reviewed

      Imamura, S, Kanesaki, Y, Ohnuma, M, Inouye, T, Sekine, Y, Fujiwara, T, Kuroiwa, T, Tanaka, K

      Proc. Natl. Acad. Sci. U S A106   12548 - 12553   1 2009

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    • Suppression of repeat-mediated gross mitochondrialgenome rearrangements by RecA in the moss Physcomitrella patens. Peer-reviewed

      Odahara, M, Kuroiwa, H, Kuroiwa, T, Sekine, Y

      Plant Cell21   1182 - 1194   1 2009

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    • Expression and complementation analyses of a chloroplast-localized homologue of bacterial RecA in the moss, Physcomitrella patens.

      関根 靖彦

      Biosci. Biotechnol. Biochem. ( 72 )   1 1 2008

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    • Polyethylene glycol (PEG)-mediated transient gene expression in a red alga, Cyanidioschyzon merolae 10D.

      関根 靖彦

      Plant & Cell Physiology ( 49 ) 117 - 120   1 1 2008

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    • Development of a new “GFP hop-on assay” system for insertion sequence transposition in Bacillus subtilis 168 using IS4Bsu1 from B. subtilis (natto).

      関根 靖彦

      Biochem. Biophys. Res. Commun. ( 355 ) 426 - 30   1 1 2007

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    • Development of an intermolecular transposition assay system in Bacillus subtilis 168 using IS4Bsu1 from Bacillus subtilis (natto)

      関根 靖彦

      Microbiology ( 153 ) 2553 - 2559   1 1 2007

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    • Involvement of mitochondrial-targeted RecA in the repair of mitochondrial DNA in the moss, Physcomitrella patens.

      関根 靖彦

      Genes & Genetic Systems ( 82 ) 43 - 51   1 1 2007

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    • Permuted tRNA genes expressed via a circular RNA intermediate in Cyanidioschyzon merolae.

      関根 靖彦

      Science ( 318 ) 450 - 453   1 1 2007

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    • The Mitochondrial Genome of the Moss Physcomitrella patens Sheds New Light on Mitochondrial Evolution in Land Plants.

      関根 靖彦

      Mol. Biol. Evol. ( 24 ) 699 - 709   1 1 2007

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    • SPLITS: a new program for predicting split and intron-containing tRNA genes at the genome level

      関根 靖彦

      In Silico Biology ( 6 ) 411 - 418   1 1 2006

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    • Molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition.

      関根 靖彦

      Mol. Cell ( 19 ) 235 - 246   1 1 2005

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    • Structural basis for lysidine formation by ATP pyrophosphatase accompanied with a lysine-specific loop and a tRNA-recognition domain.

      関根 靖彦

      Acad.Sci. USA Proc. Natl. ( 102 ) 7487 - 7492   1 1 2005

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    • Intermediate molecules generated by transposase in the pathway of transposition of bacterial insertion element IS3

      関根 靖彦

      Adv. Biophys. ( 38 ) 125 - 139   1 1 2004

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    • An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA.

      関根 靖彦

      Mol. Cell ( 12 ) 689 - 698   1 1 2003

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    • Presence of a characteristic D-D-E motif in Isl transposase

      関根 靖彦

      J. Bacteriol. ( 184 ) 6146 - 6154   1 1 2002

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    • Transposition of cyanobacterium insertion element ISY100 in Escherichia col:

      関根 靖彦

      J. Bacteriol. ( 184 ) 5104 - 5112   1 1 2002

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    • Involvement of H-NS in transpositional recombination mediated by IS1

      関根 靖彦

      J. Bacteriol. ( 183 ) 2476 - 2484   1 1 2001

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    • Mutations influencing the frr gene coding for ribosome recycling factor (RRF)

      関根 靖彦

      J. Mol. Biol. ( 295 ) 815 - 829   1 1 2000

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    • Role of ribosome recucling factor (RRF) in translational coupling

      関根 靖彦

      EMBO J. ( 19 ) 3788 - 3798   1 1 2000

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    • Linearization and transposition of circular molecules of insertion sequence IS3

      関根 靖彦

      J. Mol. Biol. ( 294 ) 21 - 34   1 1 1999

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    • Transposition of IS1 circles

      関根 靖彦

      Genes to Cells ( 4 ) 551 - 561   1 1 1999

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    • Evidence for in vivo ribosome recycling, the forth step in protein biosynthesis

      関根 靖彦

      EMBO J. ( 17 ) 1141 - 1151   1 1 1998

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    • Inhibition of transpositional recombination by OrfA and OrfB proteins encoded by insertion sequence IS3

      関根 靖彦

      Genes to Cells ( 2 ) 547 - 557   1 1 1997

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    • Isolation and characterization of IS1 circles

      関根 靖彦

      Gene   183 - 190   1 1 1997

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    • Bacterial insertion sequences

      関根 靖彦

      Cur. Topics Microbiol. Immunol. ( 204 ) 1 - 26   1 1 1996

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    • Identification and characterization of the linear IS3 molecules generated by staggered breaks

      関根 靖彦

      J. Biol. Chem. ( 271 ) 197 - 202   1 1 1996

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    • IS1-ENCODED PROTEINS, INSA AND THE INSA-B'-INSB TRANSFRAME PROTEIN (TRANSPOSASE) - FUNCTIONS DEDUCED FROM THEIR DNA-BINDING ABILITY

      N SEKINO, Y SEKINE, E OHTSUBO

      ADVANCES IN BIOPHYSICS, VOL 31, 199531 ( 31 ) 209 - 222   1995

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      Language:English   Publishing type:Research paper (other academic)   Publisher:JAPAN SCIENTIFIC SOC PRESS  

      Insertion sequence ISI (768 bp) is the smallest active transposable element in bacteria that carries imperfect terminal inverted repeats, IRL and IRR, about 30 bp in length (1, 2) (Fig. 1). IS1 is involved in various kinds of genomic rearrangements, including cointegration between two replicons (3-5) and deletion of a DNA segment adjacent to IS1 (6, 7). IS1 encodes two out-of-phase open reading frames, insA and B'-insB, which are essential for its own transposition (8-10) (Fig. 1). A frameshifting event in the -1 direction from the 3'-end region of the insA frame to an open reading frame (B' frame), which is extended from the 5'-end of the insB frame, is involved in production of the InsA-B'-InsB transframe protein with the IS1 transposase activity to mediate cointegration (11, 12). The frameshifting occurs at codon AAA for Lys encoded by insA in a run of six adenines, which is located in the overlapping region between insA and B'-insB (13) (Fig. 1).
      The InsA protein has the carboxyl-terminal region containing an alpha-helix-turn-alpha-helix motif (14) (Fig. 1), which is observed in many DNA binding proteins (25). Since ISI transposase, the InsA-B'-InsB transframe protein, includes the same motif responsible for DNA binding, it is reasonable to assume that transposase mediates transposition of ISI through binding to both IRs (IRL and IRR). It has also been demonstrated that both IRs of IS1 contain binding sites for the integration host factor IHF (16) and RNA polymerase (17, 18) in addition to those for InsA.
      In this article we present, first, additional evidence that the InsA-B'-InsB transframe protein is transposase that can promote deletion mediated by IS1. Next, we describe purification and characterization of the two IS1-encoded proteins, InsA and transposase, as fusion proteins with collagen-beta-galactosidase (LacZ). We show that InsA fused with collagen-LacZ has the specific DNA-binding ability to both IRs, while transposase fused with collagen-LacZ has not only the IR-specific DNA-binding ability, but also the nonspecific DNA-binding ability. Roles of InsA and transposase in regulation and processes of transposition are discussed.

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    • Translational control in production of transposase and in transposition of insertion sequence IS3

      関根 靖彦

      J. Mol. Biol. ( 235 ) 1406 - 1420   1 1 1994

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    • DNA sequences required for translational frameshifting in production of transposase encoded by IS1

      関根靖彦

      Mol. Gen. Genet.235, 325-332   4 1992

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    • Identification of the site of translational frameshifting required for production of the transposase encoded by insertion sequence IS 1

      関根 靖彦

      Mol. Gen. Genet ( 235 ) 317 - 324   1 1 1992

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    • Translational frameshifting in IS elements and other genetic systems

      関根 靖彦

      Kimura, M. and Takahara, N. Japan Scietific Societies Press, Tokyo/springer-Verlag, Berlin   243 - 261   1 1 1991

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    • Frameshifting is required for production of the transposase encoded by insertion sequence 1

      関根 靖彦

      Natl. Acad. Sci. USA ( 86 ) 4609 - 4613   1 1 1989

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    Books and Other Publications

    • Translational frameshifting in IS elements and other genetic systems

      ( Role: Other)

      New Aspects of The Genetics of Molecular Evolution, Edited by Kimura, M. and Takahata, N., Japan Scientific Societies Press, Tokyo/Springer-Verlag, Berlin  4 1991 

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      Language:English Book type:Other

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    Research Projects

    • Study on mobile genetic elements

      Basic Science Research Program 

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      4 1986 - Present

      Grant type:Competitive

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    • 地球環境を支える光合成酸素発生系の解明-反応機構、獲得、継承

      科学研究費助成事業 

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      4 2005 - 3 2010

      Grant type:Competitive

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    • tRNA 修飾塩基ライシジンの生合成機構の解析とそれを標的とする創薬へ向けた研究

      科学研究費助成事業 

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      4 2004 - 3 2006

      Grant type:Competitive

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    • 葉緑体の形成と維持、増殖のメカニズム-バクテリア学からのアプローチ

      立教大学  立教大学学術推進特別重点資金(立教SFR) 

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      4 2003 - 3 2004

      Grant type:Competitive

      単独研究科プロジェクト研究

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    • バクテリアのtRNA修飾酵素遺伝子の網羅的同定とtRNA修飾塩基の機能解析

      科学研究費助成事業 

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      4 2001 - 3 2003

      Grant type:Competitive

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    • バクテリアの転移性遺伝因子ISの転移とその制御の分子機構

      日本学術振興会  科学研究費助成事業 

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      4 2001 - 3 2003

      Grant type:Competitive

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    • 広く生物界に存在するIS630-Tc1ファミリーのトランスポゾンの転移機構の解明とそれを用いた植物色素体ゲノム改変系の開発

      民間財団等  旭硝子財団 

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      4 2001 - 3 2003

      Grant type:Competitive

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    • バクテリア、オルガネラゲノムの動態の研究、 トランスポゾンの研究、 バクテリア、植物のnon-coding RNAの研究、 葉緑体リボソームの研究

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      Grant type:Competitive

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